BRD-A06276885_N-Benzylnaltrindole hydrochloride_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-A06276885_N-Benzylnaltrindole hydrochloride_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACAT2 acetyl-CoA acetyltransferase 2
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
APOD apolipoprotein D
ASPH aspartate beta-hydroxylase
BASP1 brain abundant, membrane attached signal protein 1
BZW2 basic leucine zipper and W2 domains 2
CA12 carbonic anhydrase XII
CCNG2 cyclin G2
CHN2 chimerin 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CST3 cystatin C
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DPYSL2 dihydropyrimidinase-like 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPS8 epidermal growth factor receptor pathway substrate 8
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
G6PD glucose-6-phosphate dehydrogenase
GAA glucosidase, alpha; acid
GSN gelsolin
GSTM3 glutathione S-transferase mu 3 (brain)
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDI1 isopentenyl-diphosphate delta isomerase 1
IDS iduronate 2-sulfatase
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSIG1 insulin induced gene 1
JUND jun D proto-oncogene
LAMA3 laminin, alpha 3
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MEGF9 multiple EGF-like-domains 9
MMP1 matrix metallopeptidase 1
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MVP major vault protein
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PHGDH phosphoglycerate dehydrogenase
PLA2G16 phospholipase A2, group XVI
PSAP prosaposin
S100A11 S100 calcium binding protein A11
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SREBF2 sterol regulatory element binding transcription factor 2
TKT transketolase
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
CCND2 cyclin D2
CXCL8 chemokine (C-X-C motif) ligand 8
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
FASTKD1 FAST kinase domains 1
KIF20A kinesin family member 20A
LUM lumican
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MT1M metallothionein 1M
POSTN periostin, osteoblast specific factor