BRD-A06276885_N-Benzylnaltrindole hydrochloride_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-A06276885_N-Benzylnaltrindole hydrochloride_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
ANXA4 annexin A4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
C1ORF106 chromosome 1 open reading frame 106
CD24 CD24 molecule
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CSRP1 cysteine and glycine-rich protein 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHCR24 24-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DUSP4 dual specificity phosphatase 4
ENO2 enolase 2 (gamma, neuronal)
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
F13A1 coagulation factor XIII, A1 polypeptide
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FBLN1 fibulin 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FN1 fibronectin 1
FOXO3 forkhead box O3
GRN granulin
HIST1H2BG histone cluster 1, H2bg
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
IDI1 isopentenyl-diphosphate delta isomerase 1
IFITM1 interferon induced transmembrane protein 1
IGFBP4 insulin-like growth factor binding protein 4
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
KLF6 Kruppel-like factor 6
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAPT microtubule-associated protein tau
MGLL monoglyceride lipase
MSMO1 methylsterol monooxygenase 1
MX1 MX dynamin-like GTPase 1
MXI1 MAX interactor 1, dimerization protein
NEU1 sialidase 1 (lysosomal sialidase)
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NUPR1 nuclear protein, transcriptional regulator, 1
PHGDH phosphoglycerate dehydrogenase
PNMA2 paraneoplastic Ma antigen 2
RAP1GAP RAP1 GTPase activating protein
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQLE squalene epoxidase
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STC2 stanniocalcin 2
TSC22D3 TSC22 domain family, member 3
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1

decreased expression

Symbol Name
AURKA aurora kinase A
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BTG3 BTG family, member 3
CA2 carbonic anhydrase II
CDK1 cyclin-dependent kinase 1
CLU clusterin
EIF5A eukaryotic translation initiation factor 5A
FAM134B family with sequence similarity 134, member B
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
ISOC1 isochorismatase domain containing 1
MT1E metallothionein 1E
OXCT1 3-oxoacid CoA transferase 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PPIF peptidylprolyl isomerase F
TACC3 transforming, acidic coiled-coil containing protein 3
TSPAN13 tetraspanin 13
UBE2S ubiquitin-conjugating enzyme E2S
ZWINT ZW10 interacting kinetochore protein