BRD-A06276885_N-Benzylnaltrindole hydrochloride_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-A06276885_N-Benzylnaltrindole hydrochloride_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADAM9 ADAM metallopeptidase domain 9
ANPEP alanyl (membrane) aminopeptidase
C6ORF62 chromosome 6 open reading frame 62
CAPN2 calpain 2, (m/II) large subunit
CD52 CD52 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CLIC4 chloride intracellular channel 4
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCR4 chemokine (C-X-C motif) receptor 4
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DAPK1 death-associated protein kinase 1
DHCR24 24-dehydrocholesterol reductase
DSE dermatan sulfate epimerase
EZR ezrin
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
GLUL glutamate-ammonia ligase
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
ISG15 ISG15 ubiquitin-like modifier
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP7 microtubule-associated protein 7
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5
MN1 meningioma (disrupted in balanced translocation) 1
MSMO1 methylsterol monooxygenase 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRL platelet-derived growth factor receptor-like
PSAP prosaposin
PXMP2 peroxisomal membrane protein 2, 22kDa
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RIN2 Ras and Rab interactor 2
S100A9 S100 calcium binding protein A9
SC5D sterol-C5-desaturase
SCARB2 scavenger receptor class B, member 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SQSTM1 sequestosome 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
THBS1 thrombospondin 1
TMEM97 transmembrane protein 97
TOX3 TOX high mobility group box family member 3
TSC22D3 TSC22 domain family, member 3
TXN thioredoxin
TYMP thymidine phosphorylase

decreased expression

Symbol Name
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
BACE2 beta-site APP-cleaving enzyme 2
CADM1 cell adhesion molecule 1
CAST calpastatin
CP ceruloplasmin (ferroxidase)
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
KRT10 keratin 10, type I
KRT5 keratin 5, type II
KYNU kynureninase
LMO4 LIM domain only 4
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MRPS2 mitochondrial ribosomal protein S2
NDRG2 NDRG family member 2
NT5DC2 5'-nucleotidase domain containing 2
PTN pleiotrophin
RAD23B RAD23 homolog B (S. cerevisiae)
RNF167 ring finger protein 167
SEPT9 septin 9
SORD sorbitol dehydrogenase
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TGFBI transforming growth factor, beta-induced, 68kDa
TNC tenascin C
TSPYL5 TSPY-like 5
WFDC2 WAP four-disulfide core domain 2