BRD-A06276885_N-Benzylnaltrindole hydrochloride_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

211 genes differentially expressed following the BRD-A06276885_N-Benzylnaltrindole hydrochloride_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARG2 arginase 2
ASS1 argininosuccinate synthase 1
CCL20 chemokine (C-C motif) ligand 20
CD24 CD24 molecule
CD9 CD9 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLC Charcot-Leyden crystal galectin
CLDND1 claudin domain containing 1
CLEC2B C-type lectin domain family 2, member B
CLEC5A C-type lectin domain family 5, member A
CRABP2 cellular retinoic acid binding protein 2
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EXT1 exostosin glycosyltransferase 1
FAM69A family with sequence similarity 69, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGG fibrinogen gamma chain
FTH1 ferritin, heavy polypeptide 1
G6PD glucose-6-phosphate dehydrogenase
GCLC glutamate-cysteine ligase, catalytic subunit
GLRX glutaredoxin (thioltransferase)
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GRN granulin
GSDMB gasdermin B
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBP1 HMG-box transcription factor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDI1 isopentenyl-diphosphate delta isomerase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG1 insulin induced gene 1
JAG1 jagged 1
JCHAIN joining chain of multimeric IgA and IgM
KLHL9 kelch-like family member 9
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LPAR6 lysophosphatidic acid receptor 6
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAN1A1 mannosidase, alpha, class 1A, member 1
MAOA monoamine oxidase A
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSMO1 methylsterol monooxygenase 1
MTUS1 microtubule associated tumor suppressor 1
MXI1 MAX interactor 1, dimerization protein
NCF2 neutrophil cytosolic factor 2
NPC1 Niemann-Pick disease, type C1
NRP1 neuropilin 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PEG10 paternally expressed 10
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PON3 paraoxonase 3
POU2AF1 POU class 2 associating factor 1
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKCQ protein kinase C, theta
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SERINC5 serine incorporator 5
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TLE4 transducin-like enhancer of split 4
TNFRSF17 tumor necrosis factor receptor superfamily, member 17
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
UGDH UDP-glucose 6-dehydrogenase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A
VNN1 vanin 1
VTCN1 V-set domain containing T cell activation inhibitor 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACTA2 actin, alpha 2, smooth muscle, aorta
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
AURKA aurora kinase A
AURKB aurora kinase B
BAG2 BCL2-associated athanogene 2
BIRC5 baculoviral IAP repeat containing 5
BLM Bloom syndrome, RecQ helicase-like
BST2 bone marrow stromal cell antigen 2
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CASP2 caspase 2, apoptosis-related cysteine peptidase
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
COL3A1 collagen, type III, alpha 1
CRIP1 cysteine-rich protein 1 (intestinal)
DCN decorin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCI Fanconi anemia, complementation group I
FBLN5 fibulin 5
FSTL1 follistatin-like 1
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GMDS GDP-mannose 4,6-dehydratase
GPM6B glycoprotein M6B
H2AFX H2A histone family, member X
HDGFRP3 hepatoma-derived growth factor, related protein 3
HES1 hes family bHLH transcription factor 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOXC6 homeobox C6
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP7 insulin-like growth factor binding protein 7
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LUM lumican
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAP2K6 mitogen-activated protein kinase kinase 6
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIS18A MIS18 kinetochore protein A
MKI67 marker of proliferation Ki-67
MT1M metallothionein 1M
MTA1 metastasis associated 1
MYCBP MYC binding protein
NMI N-myc (and STAT) interactor
NOLC1 nucleolar and coiled-body phosphoprotein 1
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PBK PDZ binding kinase
PODXL podocalyxin-like
POSTN periostin, osteoblast specific factor
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PTN pleiotrophin
RAD51C RAD51 paralog C
RBP1 retinol binding protein 1, cellular
RCN1 reticulocalbin 1, EF-hand calcium binding domain
RPS11 ribosomal protein S11
RRM1 ribonucleotide reductase M1
S100A2 S100 calcium binding protein A2
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
SLIRP SRA stem-loop interacting RNA binding protein
SMS spermine synthase
SNRPF small nuclear ribonucleoprotein polypeptide F
SORBS1 sorbin and SH3 domain containing 1
SORD sorbitol dehydrogenase
SOX9 SRY (sex determining region Y)-box 9
SPRR3 small proline-rich protein 3
TACC3 transforming, acidic coiled-coil containing protein 3
TAGLN transgelin
TFF3 trefoil factor 3 (intestinal)
TNC tenascin C
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TUBB3 tubulin, beta 3 class III
TUBB4B tubulin, beta 4B class IVb
UBE2S ubiquitin-conjugating enzyme E2S
UPK1B uroplakin 1B
WIF1 WNT inhibitory factor 1
ZWILCH zwilch kinetochore protein