BRD-A06276885_N-Benzylnaltrindole hydrochloride_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

184 genes differentially expressed following the BRD-A06276885_N-Benzylnaltrindole hydrochloride_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAN aggrecan
ACAT2 acetyl-CoA acetyltransferase 2
ADGRG2 adhesion G protein-coupled receptor G2
AIM1 absent in melanoma 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AMDHD2 amidohydrolase domain containing 2
ARL4C ADP-ribosylation factor-like 4C
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C14ORF1 chromosome 14 open reading frame 1
CD52 CD52 molecule
CD9 CD9 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CPA3 carboxypeptidase A3 (mast cell)
CTSK cathepsin K
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ELOVL6 ELOVL fatty acid elongase 6
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FTH1 ferritin, heavy polypeptide 1
GLRX glutaredoxin (thioltransferase)
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
GRN granulin
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI30 interferon, gamma-inducible protein 30
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAG1 jagged 1
KRT19 keratin 19, type I
KYNU kynureninase
LDLR low density lipoprotein receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LIPA lipase A, lysosomal acid, cholesterol esterase
LPIN1 lipin 1
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MEIS1 Meis homeobox 1
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
MSMO1 methylsterol monooxygenase 1
NELL2 NEL-like 2 (chicken)
NEU1 sialidase 1 (lysosomal sialidase)
NPC1 Niemann-Pick disease, type C1
NPIPB3 nuclear pore complex interacting protein family, member B3
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUPR1 nuclear protein, transcriptional regulator, 1
PDE4DIP phosphodiesterase 4D interacting protein
PERP PERP, TP53 apoptosis effector
PLSCR1 phospholipid scramblase 1
PYCARD PYD and CARD domain containing
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC1 syndecan 1
SEPP1 selenoprotein P, plasma, 1
SFN stratifin
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC38A1 solute carrier family 38, member 1
SNAI2 snail family zinc finger 2
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPP1 secreted phosphoprotein 1
SQLE squalene epoxidase
SQSTM1 sequestosome 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STAB1 stabilin 1
STEAP3 STEAP family member 3, metalloreductase
SULF1 sulfatase 1
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM97 transmembrane protein 97
TPP1 tripeptidyl peptidase I
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TYROBP TYRO protein tyrosine kinase binding protein
WIPI1 WD repeat domain, phosphoinositide interacting 1
WT1 Wilms tumor 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ACAT1 acetyl-CoA acetyltransferase 1
AK2 adenylate kinase 2
AKAP12 A kinase (PRKA) anchor protein 12
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAG2 BCL2-associated athanogene 2
BBX bobby sox homolog (Drosophila)
BEX1 brain expressed, X-linked 1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CAPZB capping protein (actin filament) muscle Z-line, beta
CCL2 chemokine (C-C motif) ligand 2
CCND2 cyclin D2
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CFLAR CASP8 and FADD-like apoptosis regulator
CHI3L2 chitinase 3-like 2
COL5A1 collagen, type V, alpha 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CSRP2 cysteine and glycine-rich protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DERA deoxyribose-phosphate aldolase (putative)
DIO2 deiodinase, iodothyronine, type II
ECI2 enoyl-CoA delta isomerase 2
EFHD1 EF-hand domain family, member D1
EGF epidermal growth factor
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHA3 EPH receptor A3
FKBP1B FK506 binding protein 1B, 12.6 kDa
FLNB filamin B, beta
GADD45B growth arrest and DNA-damage-inducible, beta
GAS7 growth arrest-specific 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GBP1 guanylate binding protein 1, interferon-inducible
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
GTPBP8 GTP-binding protein 8 (putative)
HILPDA hypoxia inducible lipid droplet-associated
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
LAMC1 laminin, gamma 1 (formerly LAMB2)
LDHB lactate dehydrogenase B
LOX lysyl oxidase
LRRC17 leucine rich repeat containing 17
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAPT microtubule-associated protein tau
MBNL1 muscleblind-like splicing regulator 1
MRPL42 mitochondrial ribosomal protein L42
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MYCBP MYC binding protein
NDN necdin, melanoma antigen (MAGE) family member
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEK7 NIMA-related kinase 7
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NID2 nidogen 2 (osteonidogen)
NME4 NME/NM23 nucleoside diphosphate kinase 4
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCCB propionyl CoA carboxylase, beta polypeptide
PDLIM5 PDZ and LIM domain 5
PLAGL1 pleiomorphic adenoma gene-like 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PON2 paraoxonase 2
PRPS1 phosphoribosyl pyrophosphate synthetase 1
QDPR quinoid dihydropteridine reductase
RCAN1 regulator of calcineurin 1
RGS4 regulator of G-protein signaling 4
RPS11 ribosomal protein S11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SMYD3 SET and MYND domain containing 3
SNX10 sorting nexin 10
STK17A serine/threonine kinase 17a
TCF4 transcription factor 4
TNS1 tensin 1
TOX thymocyte selection-associated high mobility group box
TUFT1 tuftelin 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB20 zinc finger and BTB domain containing 20