BRD-A05680309_MLS-0390982_HA1E_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

100 genes differentially expressed following the BRD-A05680309_MLS-0390982_HA1E_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
AGTR1 angiotensin II receptor, type 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
C3 complement component 3
CCND2 cyclin D2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL8 chemokine (C-X-C motif) ligand 8
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DOCK4 dedicator of cytokinesis 4
EIF5A eukaryotic translation initiation factor 5A
EVI2A ecotropic viral integration site 2A
FGFR3 fibroblast growth factor receptor 3
HSPH1 heat shock 105kDa/110kDa protein 1
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IL17RB interleukin 17 receptor B
IL7R interleukin 7 receptor
ISG20 interferon stimulated exonuclease gene 20kDa
ISOC1 isochorismatase domain containing 1
ITGA6 integrin, alpha 6
KAT6B K(lysine) acetyltransferase 6B
LPAR6 lysophosphatidic acid receptor 6
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MMD monocyte to macrophage differentiation-associated
MSR1 macrophage scavenger receptor 1
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDPN podoplanin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLAU plasminogen activator, urokinase
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSTPIP2 proline-serine-threonine phosphatase interacting protein 2
PTPRC protein tyrosine phosphatase, receptor type, C
RBP4 retinol binding protein 4, plasma
REG1A regenerating islet-derived 1 alpha
TGFBI transforming growth factor, beta-induced, 68kDa
TM4SF1 transmembrane 4 L six family member 1
TMEM123 transmembrane protein 123
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
ANXA6 annexin A6
AQP3 aquaporin 3 (Gill blood group)
CAPN2 calpain 2, (m/II) large subunit
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNM1 dynamin 1
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
ENAH enabled homolog (Drosophila)
FAS Fas cell surface death receptor
GSTA4 glutathione S-transferase alpha 4
HES1 hes family bHLH transcription factor 1
HOXC10 homeobox C10
HOXC4 homeobox C4
HOXC6 homeobox C6
HSPB8 heat shock 22kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGKC immunoglobulin kappa constant
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
ITM2C integral membrane protein 2C
LMCD1 LIM and cysteine-rich domains 1
LRRC1 leucine rich repeat containing 1
LYST lysosomal trafficking regulator
MAGED1 melanoma antigen family D1
MAP2K6 mitogen-activated protein kinase kinase 6
MUC4 mucin 4, cell surface associated
MYH10 myosin, heavy chain 10, non-muscle
NCOA1 nuclear receptor coactivator 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NEFL neurofilament, light polypeptide
NEFM neurofilament, medium polypeptide
NOTCH2 notch 2
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAX8 paired box 8
PFKP phosphofructokinase, platelet
RGS2 regulator of G-protein signaling 2
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SNRPE small nuclear ribonucleoprotein polypeptide E
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPP1 secreted phosphoprotein 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TP53 tumor protein p53
TRAM2 translocation associated membrane protein 2
VCAN versican
ZNF185 zinc finger protein 185 (LIM domain)