BRD-A05565054_(2-ethylpiperidin-1-yl)(4-(hydroxydiphenylmethyl)-1H-1,2,3-triazol-1-yl)methanone_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-A05565054_(2-ethylpiperidin-1-yl)(4-(hydroxydiphenylmethyl)-1H-1,2,3-triazol-1-yl)methanone_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
APOD apolipoprotein D
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
AUTS2 autism susceptibility candidate 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C10ORF10 chromosome 10 open reading frame 10
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DHRS3 dehydrogenase/reductase (SDR family) member 3
DPYSL3 dihydropyrimidinase-like 3
ENO1 enolase 1, (alpha)
EPAS1 endothelial PAS domain protein 1
FADS1 fatty acid desaturase 1
FDFT1 farnesyl-diphosphate farnesyltransferase 1
H1F0 H1 histone family, member 0
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HK2 hexokinase 2
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MSMO1 methylsterol monooxygenase 1
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NFIB nuclear factor I/B
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PSAT1 phosphoserine aminotransferase 1
RGCC regulator of cell cycle
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SQLE squalene epoxidase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TPD52 tumor protein D52
TRIB3 tribbles pseudokinase 3
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3

decreased expression

Symbol Name
DHRS2 dehydrogenase/reductase (SDR family) member 2
DHRS7 dehydrogenase/reductase (SDR family) member 7
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FASTKD5 FAST kinase domains 5
FOS FBJ murine osteosarcoma viral oncogene homolog
H3F3B H3 histone, family 3B (H3.3B)
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IL6R interleukin 6 receptor
MARCKS myristoylated alanine-rich protein kinase C substrate
PLK1 polo-like kinase 1
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma
PRKCA protein kinase C, alpha
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10