BRD-A05352148_Ipratropium bromide_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

85 genes differentially expressed following the BRD-A05352148_Ipratropium bromide_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ANXA1 annexin A1
ATF3 activating transcription factor 3
CD9 CD9 molecule
CRABP2 cellular retinoic acid binding protein 2
CST1 cystatin SN
CXADR coxsackie virus and adenovirus receptor
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
ENAH enabled homolog (Drosophila)
GJA1 gap junction protein, alpha 1, 43kDa
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
HCAR3 hydroxycarboxylic acid receptor 3
HP haptoglobin
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
KIAA0226L KIAA0226-like
KRT13 keratin 13, type I
KRT15 keratin 15, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
MPZL2 myelin protein zero-like 2
MTSS1 metastasis suppressor 1
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PERP PERP, TP53 apoptosis effector
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SMC1A structural maintenance of chromosomes 1A
SPARCL1 SPARC-like 1 (hevin)
SPRR3 small proline-rich protein 3
TCF4 transcription factor 4
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRAPPC6A trafficking protein particle complex 6A
TSC22D1 TSC22 domain family, member 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ANXA3 annexin A3
ANXA6 annexin A6
AP2B1 adaptor-related protein complex 2, beta 1 subunit
BST2 bone marrow stromal cell antigen 2
CDC42 cell division cycle 42
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CXCL12 chemokine (C-X-C motif) ligand 12
DAPK1 death-associated protein kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FLNB filamin B, beta
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
KDM5D lysine (K)-specific demethylase 5D
MARCH8 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
PDIA6 protein disulfide isomerase family A, member 6
PEG3 paternally expressed 3
PENK proenkephalin
PLAC8 placenta-specific 8
PROM1 prominin 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RAD51C RAD51 paralog C
REEP1 receptor accessory protein 1
SESN1 sestrin 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SRPX sushi-repeat containing protein, X-linked
TECR trans-2,3-enoyl-CoA reductase
TLE4 transducin-like enhancer of split 4
TPM1 tropomyosin 1 (alpha)
UBE3B ubiquitin protein ligase E3B
USP9Y ubiquitin specific peptidase 9, Y-linked
YME1L1 YME1-like 1 ATPase