BRD-A04756508_NORGESTIMATE_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-A04756508_NORGESTIMATE_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
AGR2 anterior gradient 2
ANPEP alanyl (membrane) aminopeptidase
ANXA3 annexin A3
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX3 armadillo repeat containing, X-linked 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CAPN2 calpain 2, (m/II) large subunit
CCNG2 cyclin G2
CHIC2 cysteine-rich hydrophobic domain 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTH1 cytohesin 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
EBP emopamil binding protein (sterol isomerase)
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
GLRX glutaredoxin (thioltransferase)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH2 isocitrate dehydrogenase 2 (NADP+), mitochondrial
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IQGAP1 IQ motif containing GTPase activating protein 1
KIAA1324 KIAA1324
KIF14 kinesin family member 14
KLK2 kallikrein-related peptidase 2
KRT19 keratin 19, type I
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
LTF lactotransferrin
MSMO1 methylsterol monooxygenase 1
NKX3-1 NK3 homeobox 1
OLFM4 olfactomedin 4
PCP4 Purkinje cell protein 4
PDE4B phosphodiesterase 4B, cAMP-specific
PDIA3 protein disulfide isomerase family A, member 3
PENK proenkephalin
PIP prolactin-induced protein
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SOX9 SRY (sex determining region Y)-box 9
SPDEF SAM pointed domain containing ETS transcription factor
SYNM synemin, intermediate filament protein
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
AHNAK2 AHNAK nucleoprotein 2
ASPH aspartate beta-hydroxylase
BAMBI BMP and activin membrane-bound inhibitor
BOP1 block of proliferation 1
C8ORF33 chromosome 8 open reading frame 33
CADM1 cell adhesion molecule 1
CCDC85B coiled-coil domain containing 85B
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CX3CR1 chemokine (C-X3-C motif) receptor 1
DPH2 DPH2 homolog (S. cerevisiae)
EIF5A eukaryotic translation initiation factor 5A
EXOSC4 exosome component 4
EXOSC5 exosome component 5
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GNL3 guanine nucleotide binding protein-like 3 (nucleolar)
GRWD1 glutamate-rich WD repeat containing 1
HEATR1 HEAT repeat containing 1
IGFBP3 insulin-like growth factor binding protein 3
IGLL1 immunoglobulin lambda-like polypeptide 1
LAPTM4B lysosomal protein transmembrane 4 beta
LOXL1 lysyl oxidase-like 1
MRTO4 mRNA turnover 4 homolog (S. cerevisiae)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP16 NOP16 nucleolar protein
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
PLAGL1 pleiomorphic adenoma gene-like 1
PLS3 plastin 3
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PUF60 poly-U binding splicing factor 60KDa
RPL37A ribosomal protein L37a
RPS21 ribosomal protein S21
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SNRPE small nuclear ribonucleoprotein polypeptide E
SPINK1 serine peptidase inhibitor, Kazal type 1
SRM spermidine synthase
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
WDR3 WD repeat domain 3
WT1 Wilms tumor 1