BRD-A04756508_NORGESTIMATE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-A04756508_NORGESTIMATE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1
ADCY9 adenylate cyclase 9
ALDOB aldolase B, fructose-bisphosphate
ARG2 arginase 2
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BID BH3 interacting domain death agonist
CA2 carbonic anhydrase II
CA4 carbonic anhydrase IV
CAPG capping protein (actin filament), gelsolin-like
CASP10 caspase 10, apoptosis-related cysteine peptidase
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CHGB chromogranin B
CKB creatine kinase, brain
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CTNND1 catenin (cadherin-associated protein), delta 1
CYBRD1 cytochrome b reductase 1
DAXX death-domain associated protein
DENND1B DENN/MADD domain containing 1B
FAM69A family with sequence similarity 69, member A
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FLT1 fms-related tyrosine kinase 1
FMO5 flavin containing monooxygenase 5
FOXF2 forkhead box F2
FRZB frizzled-related protein
FZD1 frizzled class receptor 1
FZD5 frizzled class receptor 5
GJA1 gap junction protein, alpha 1, 43kDa
GREM1 gremlin 1, DAN family BMP antagonist
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSDMB gasdermin B
GSTA1 glutathione S-transferase alpha 1
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAT1 histone acetyltransferase 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DRA major histocompatibility complex, class II, DR alpha
HOXB2 homeobox B2
HSPA4 heat shock 70kDa protein 4
HSPB3 heat shock 27kDa protein 3
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IPO13 importin 13
JCHAIN joining chain of multimeric IgA and IgM
MAOA monoamine oxidase A
MBOAT7 membrane bound O-acyltransferase domain containing 7
MMP2 matrix metallopeptidase 2
MT1F metallothionein 1F
MT1G metallothionein 1G
NFE2L2 nuclear factor, erythroid 2-like 2
NT5E 5'-nucleotidase, ecto (CD73)
NVL nuclear VCP-like
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCP4 Purkinje cell protein 4
PDE8B phosphodiesterase 8B
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R10 protein phosphatase 1, regulatory subunit 10
PTPRK protein tyrosine phosphatase, receptor type, K
RAB21 RAB21, member RAS oncogene family
RAI14 retinoic acid induced 14
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMC3 structural maintenance of chromosomes 3
SST somatostatin
STS steroid sulfatase (microsomal), isozyme S
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SWAP70 SWAP switching B-cell complex 70kDa subunit
TBXA2R thromboxane A2 receptor
TESK1 testis-specific kinase 1
TLK2 tousled-like kinase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRAP1 TNF receptor-associated protein 1
UBE2J1 ubiquitin-conjugating enzyme E2, J1
VEGFA vascular endothelial growth factor A
WFS1 Wolfram syndrome 1 (wolframin)
ZBTB16 zinc finger and BTB domain containing 16
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
BICC1 BicC family RNA binding protein 1
BMI1 BMI1 proto-oncogene, polycomb ring finger
BST2 bone marrow stromal cell antigen 2
C1R complement component 1, r subcomponent
C1S complement component 1, s subcomponent
C6ORF48 chromosome 6 open reading frame 48
CD59 CD59 molecule, complement regulatory protein
CSRP1 cysteine and glycine-rich protein 1
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYBA cytochrome b-245, alpha polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DHRS7 dehydrogenase/reductase (SDR family) member 7
ELK3 ELK3, ETS-domain protein (SRF accessory protein 2)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP11 FK506 binding protein 11, 19 kDa
GOLGA8A golgin A8 family, member A
GPATCH8 G patch domain containing 8
GPX3 glutathione peroxidase 3
GPX7 glutathione peroxidase 7
GRAMD1B GRAM domain containing 1B
HOXB7 homeobox B7
HOXC6 homeobox C6
IFI44L interferon-induced protein 44-like
KAZN kazrin, periplakin interacting protein
KRT10 keratin 10, type I
KRT14 keratin 14, type I
KRT17 keratin 17, type I
LAMB1 laminin, beta 1
LAMC2 laminin, gamma 2
LEPR leptin receptor
LMCD1 LIM and cysteine-rich domains 1
MRPS30 mitochondrial ribosomal protein S30
NCBP2 nuclear cap binding protein subunit 2, 20kDa
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NPC2 Niemann-Pick disease, type C2
PAK1 p21 protein (Cdc42/Rac)-activated kinase 1
PROS1 protein S (alpha)
PTN pleiotrophin
QDPR quinoid dihydropteridine reductase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBP1 retinol binding protein 1, cellular
RGS2 regulator of G-protein signaling 2
RPL37A ribosomal protein L37a
RPS26 ribosomal protein S26
S100A2 S100 calcium binding protein A2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELL selectin L
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SFRP1 secreted frizzled-related protein 1
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SPRR1A small proline-rich protein 1A
SRP72 signal recognition particle 72kDa
SSBP1 single-stranded DNA binding protein 1, mitochondrial
TAGLN transgelin
TBC1D4 TBC1 domain family, member 4
TGFBI transforming growth factor, beta-induced, 68kDa
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TRBC1 T cell receptor beta constant 1
TSPAN8 tetraspanin 8
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UPK1B uroplakin 1B
YME1L1 YME1-like 1 ATPase