BRD-A04668240_CGP 52432_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-A04668240_CGP 52432_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AK1 adenylate kinase 1
ALOX15B arachidonate 15-lipoxygenase, type B
ANKRD10 ankyrin repeat domain 10
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
CCNA1 cyclin A1
CCND2 cyclin D2
CD24 CD24 molecule
CD9 CD9 molecule
CRABP1 cellular retinoic acid binding protein 1
EIF5A eukaryotic translation initiation factor 5A
ESRP2 epithelial splicing regulatory protein 2
FKBP5 FK506 binding protein 5
GOLGA8A golgin A8 family, member A
GOLM1 golgi membrane protein 1
HIST1H1C histone cluster 1, H1c
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGFBP5 insulin-like growth factor binding protein 5
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LUM lumican
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MB myoglobin
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MGP matrix Gla protein
MLXIP MLX interacting protein
MMP9 matrix metallopeptidase 9
MYBPC1 myosin binding protein C, slow type
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
NQO1 NAD(P)H dehydrogenase, quinone 1
PDLIM5 PDZ and LIM domain 5
PHYH phytanoyl-CoA 2-hydroxylase
POSTN periostin, osteoblast specific factor
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAP2A RAP2A, member of RAS oncogene family
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RRAD Ras-related associated with diabetes
RRAGD Ras-related GTP binding D
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SCAF11 SR-related CTD-associated factor 11
SEPP1 selenoprotein P, plasma, 1
SFRP1 secreted frizzled-related protein 1
SRRM2 serine/arginine repetitive matrix 2
TFF3 trefoil factor 3 (intestinal)
THBS4 thrombospondin 4
TMEM176B transmembrane protein 176B
TNNT1 troponin T type 1 (skeletal, slow)
TNS1 tensin 1
TTN titin
TUBB2A tubulin, beta 2A class IIa
TUBB6 tubulin, beta 6 class V

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADM adrenomedullin
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
AZIN1 antizyme inhibitor 1
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CIAPIN1 cytokine induced apoptosis inhibitor 1
CLDN10 claudin 10
DCK deoxycytidine kinase
EXT1 exostosin glycosyltransferase 1
FBXO21 F-box protein 21
FZD6 frizzled class receptor 6
GATA6 GATA binding protein 6
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GJA1 gap junction protein, alpha 1, 43kDa
GPC4 glypican 4
GPM6A glycoprotein M6A
GREM1 gremlin 1, DAN family BMP antagonist
HES1 hes family bHLH transcription factor 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
JCHAIN joining chain of multimeric IgA and IgM
KANK1 KN motif and ankyrin repeat domains 1
KDM3A lysine (K)-specific demethylase 3A
KYNU kynureninase
LOC100505650 uncharacterized LOC100505650
LRRC16A leucine rich repeat containing 16A
LYPD1 LY6/PLAUR domain containing 1
MT1M metallothionein 1M
MTMR11 myotubularin related protein 11
N4BP2L1 NEDD4 binding protein 2-like 1
NLGN4X neuroligin 4, X-linked
PBX1 pre-B-cell leukemia homeobox 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PON2 paraoxonase 2
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PROM1 prominin 1
PTPRK protein tyrosine phosphatase, receptor type, K
RNH1 ribonuclease/angiogenin inhibitor 1
RPL37A ribosomal protein L37a
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCG5 secretogranin V
SCYL3 SCY1-like 3 (S. cerevisiae)
SELL selectin L
SLC35F2 solute carrier family 35, member F2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNX10 sorting nexin 10
SPON1 spondin 1, extracellular matrix protein
TFRC transferrin receptor
TGFBI transforming growth factor, beta-induced, 68kDa
TSPAN12 tetraspanin 12
UFM1 ubiquitin-fold modifier 1
VAT1 vesicle amine transport 1
VLDLR very low density lipoprotein receptor