BRD-A04392722_NCGC00181233-01_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

234 genes differentially expressed following the BRD-A04392722_NCGC00181233-01_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
ANPEP alanyl (membrane) aminopeptidase
CA2 carbonic anhydrase II
CALR calreticulin
CD200 CD200 molecule
CHN2 chimerin 2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL15A1 collagen, type XV, alpha 1
COL4A5 collagen, type IV, alpha 5
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
EDEM3 ER degradation enhancer, mannosidase alpha-like 3
EMX2 empty spiracles homeobox 2
FABP6 fatty acid binding protein 6, ileal
FAM198B family with sequence similarity 198, member B
FZD2 frizzled class receptor 2
GALC galactosylceramidase
GAS6 growth arrest-specific 6
GOLM1 golgi membrane protein 1
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HEPH hephaestin
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HHEX hematopoietically expressed homeobox
HIST1H2BG histone cluster 1, H2bg
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPA2 heat shock 70kDa protein 2
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
MAN2A1 mannosidase, alpha, class 2A, member 1
MEG3 maternally expressed 3 (non-protein coding)
MEIS1 Meis homeobox 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP11 matrix metallopeptidase 11
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
NFE2 nuclear factor, erythroid 2
NRGN neurogranin (protein kinase C substrate, RC3)
OLFML2A olfactomedin-like 2A
OLFML3 olfactomedin-like 3
PDIA3 protein disulfide isomerase family A, member 3
PLK2 polo-like kinase 2
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QSOX1 quiescin Q6 sulfhydryl oxidase 1
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RGCC regulator of cell cycle
RGS4 regulator of G-protein signaling 4
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPON2 spondin 2, extracellular matrix protein
SST somatostatin
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFF3 trefoil factor 3 (intestinal)
TGFA transforming growth factor, alpha
TLK2 tousled-like kinase 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIB2 tribbles pseudokinase 2
TXNIP thioredoxin interacting protein
TYMP thymidine phosphorylase
UBE2A ubiquitin-conjugating enzyme E2A
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACKR1 atypical chemokine receptor 1 (Duffy blood group)
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADI1 acireductone dioxygenase 1
ADIPOQ adiponectin, C1Q and collagen domain containing
AGR2 anterior gradient 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AOX1 aldehyde oxidase 1
APOD apolipoprotein D
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ATF1 activating transcription factor 1
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD52 CD52 molecule
CD58 CD58 molecule
CDK4 cyclin-dependent kinase 4
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CETN3 centrin, EF-hand protein, 3
CFD complement factor D (adipsin)
CFH complement factor H
CHMP4A charged multivesicular body protein 4A
CHPT1 choline phosphotransferase 1
CHRDL1 chordin-like 1
CLU clusterin
COL4A3 collagen, type IV, alpha 3 (Goodpasture antigen)
COX11 COX11 cytochrome c oxidase copper chaperone
CP ceruloplasmin (ferroxidase)
CPB1 carboxypeptidase B1 (tissue)
CREB1 cAMP responsive element binding protein 1
CRYAB crystallin, alpha B
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTSS cathepsin S
CTTN cortactin
CXCL12 chemokine (C-X-C motif) ligand 12
DCK deoxycytidine kinase
DCLK1 doublecortin-like kinase 1
DEPTOR DEP domain containing MTOR-interacting protein
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYNLT3 dynein, light chain, Tctex-type 3
EBNA1BP2 EBNA1 binding protein 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4B eukaryotic translation initiation factor 4B
EIF5A eukaryotic translation initiation factor 5A
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FANCF Fanconi anemia, complementation group F
FHL1 four and a half LIM domains 1
FOXC1 forkhead box C1
FXYD2 FXYD domain containing ion transport regulator 2
G0S2 G0/G1 switch 2
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATAD1 GATA zinc finger domain containing 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GMNN geminin, DNA replication inhibitor
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
GSPT2 G1 to S phase transition 2
GTPBP8 GTP-binding protein 8 (putative)
HACD2 3-hydroxyacyl-CoA dehydratase 2
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLF hepatic leukemia factor
IGLL1 immunoglobulin lambda-like polypeptide 1
INSIG1 insulin induced gene 1
KYNU kynureninase
LEFTY1 left-right determination factor 1
LXN latexin
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MAP1B microtubule-associated protein 1B
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MCOLN1 mucolipin 1
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLF1 myeloid leukemia factor 1
MPZL1 myelin protein zero-like 1
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A
MYO5C myosin VC
NAMPT nicotinamide phosphoribosyltransferase
NAV2 neuron navigator 2
NFIB nuclear factor I/B
NME1 NME/NM23 nucleoside diphosphate kinase 1
NMU neuromedin U
NOV nephroblastoma overexpressed
NOVA1 neuro-oncological ventral antigen 1
NPC1 Niemann-Pick disease, type C1
NRIP1 nuclear receptor interacting protein 1
OAT ornithine aminotransferase
OGN osteoglycin
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCDH9 protocadherin 9
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDE4B phosphodiesterase 4B, cAMP-specific
PEG10 paternally expressed 10
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PIP4K2C phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
PLIN1 perilipin 1
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTP4A2 protein tyrosine phosphatase type IVA, member 2
QDPR quinoid dihydropteridine reductase
RAD51C RAD51 paralog C
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RBKS ribokinase
RBM34 RNA binding motif protein 34
REEP5 receptor accessory protein 5
S100A13 S100 calcium binding protein A13
S100A2 S100 calcium binding protein A2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SET SET nuclear proto-oncogene
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A46 solute carrier family 25, member 46
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLIT2 slit homolog 2 (Drosophila)
SNX2 sorting nexin 2
SPATA20 spermatogenesis associated 20
SRSF11 serine/arginine-rich splicing factor 11
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TBC1D16 TBC1 domain family, member 16
TCEAL4 transcription elongation factor A (SII)-like 4
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFPI2 tissue factor pathway inhibitor 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM4 transglutaminase 4
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP4 TIMP metallopeptidase inhibitor 4
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TMEM100 transmembrane protein 100
TMEM50B transmembrane protein 50B
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM1 translocation associated membrane protein 1
TRPS1 trichorhinophalangeal syndrome I
TSPAN13 tetraspanin 13
TSPAN31 tetraspanin 31
TTC3 tetratricopeptide repeat domain 3
TXNDC9 thioredoxin domain containing 9
UFM1 ubiquitin-fold modifier 1
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WRB tryptophan rich basic protein
WWP1 WW domain containing E3 ubiquitin protein ligase 1
XPO7 exportin 7
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF331 zinc finger protein 331