BRD-A04172077_NP-002491_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

140 genes differentially expressed following the BRD-A04172077_NP-002491_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AHNAK2 AHNAK nucleoprotein 2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ANGPTL2 angiopoietin-like 2
ARL4C ADP-ribosylation factor-like 4C
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
CAV1 caveolin 1, caveolae protein, 22kDa
CCND2 cyclin D2
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD93 CD93 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CLEC2B C-type lectin domain family 2, member B
CNN3 calponin 3, acidic
COL6A3 collagen, type VI, alpha 3
COPA coatomer protein complex, subunit alpha
CPB1 carboxypeptidase B1 (tissue)
CST6 cystatin E/M
CTSK cathepsin K
DCT dopachrome tautomerase
DPYSL3 dihydropyrimidinase-like 3
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GNG11 guanine nucleotide binding protein (G protein), gamma 11
H2AFY H2A histone family, member Y
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA1 high mobility group AT-hook 1
HOPX HOP homeobox
IFI16 interferon, gamma-inducible protein 16
IGFBP7 insulin-like growth factor binding protein 7
IL1RN interleukin 1 receptor antagonist
IL32 interleukin 32
IL6ST interleukin 6 signal transducer
IRF6 interferon regulatory factor 6
LAMP1 lysosomal-associated membrane protein 1
LAPTM5 lysosomal protein transmembrane 5
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
LY96 lymphocyte antigen 96
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MEF2C myocyte enhancer factor 2C
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MYCL v-myc avian myelocytomatosis viral oncogene lung carcinoma derived homolog
MYOF myoferlin
NDP Norrie disease (pseudoglioma)
NELL2 NEL-like 2 (chicken)
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PLAT plasminogen activator, tissue
PNMAL1 paraneoplastic Ma antigen family-like 1
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRSS3 protease, serine, 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
RGCC regulator of cell cycle
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A9 S100 calcium binding protein A9
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SNAI2 snail family zinc finger 2
SRGN serglycin
TBX3 T-box 3
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TM4SF1 transmembrane 4 L six family member 1
TMEM45A transmembrane protein 45A
VCAN versican
VNN1 vanin 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
ANKRD36B ankyrin repeat domain 36B
ATF1 activating transcription factor 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
AURKA aurora kinase A
BPTF bromodomain PHD finger transcription factor
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CD58 CD58 molecule
CDC20 cell division cycle 20
CGRRF1 cell growth regulator with ring finger domain 1
CNOT4 CCR4-NOT transcription complex, subunit 4
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FGF13 fibroblast growth factor 13
GABPB1 GA binding protein transcription factor, beta subunit 1
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2
GRWD1 glutamate-rich WD repeat containing 1
H2AFX H2A histone family, member X
HAMP hepcidin antimicrobial peptide
HIST1H4C histone cluster 1, H4c
HMOX1 heme oxygenase 1
HN1 hematological and neurological expressed 1
HSPA2 heat shock 70kDa protein 2
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IGF1R insulin-like growth factor 1 receptor
JADE2 jade family PHD finger 2
JMJD6 jumonji domain containing 6
KEAP1 kelch-like ECH-associated protein 1
KIAA0101 KIAA0101
NCOA3 nuclear receptor coactivator 3
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive
NOL11 nucleolar protein 11
NQO1 NAD(P)H dehydrogenase, quinone 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP85 nucleoporin 85kDa
PARP2 poly (ADP-ribose) polymerase 2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
REEP1 receptor accessory protein 1
RPP38 ribonuclease P/MRP 38kDa subunit
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNX11 sorting nexin 11
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SRSF7 serine/arginine-rich splicing factor 7
TBX2 T-box 2
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMEM100 transmembrane protein 100
TNPO1 transportin 1
TRAK2 trafficking protein, kinesin binding 2
TXLNA taxilin alpha
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
ZMYM2 zinc finger, MYM-type 2
ZWILCH zwilch kinetochore protein