BRD-A04172077_NP-002491_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

218 genes differentially expressed following the BRD-A04172077_NP-002491_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACKR3 atypical chemokine receptor 3
ADAM9 ADAM metallopeptidase domain 9
AEBP1 AE binding protein 1
ALDH3A2 aldehyde dehydrogenase 3 family, member A2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
BCHE butyrylcholinesterase
BPHL biphenyl hydrolase-like (serine hydrolase)
C3 complement component 3
CA9 carbonic anhydrase IX
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CD47 CD47 molecule
CERS6 ceramide synthase 6
CHGB chromogranin B
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL4A5 collagen, type IV, alpha 5
CPM carboxypeptidase M
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
EGLN3 egl-9 family hypoxia-inducible factor 3
F11R F11 receptor
FAM69A family with sequence similarity 69, member A
FBN2 fibrillin 2
FGFR3 fibroblast growth factor receptor 3
FLT1 fms-related tyrosine kinase 1
FOXF1 forkhead box F1
GM2A GM2 ganglioside activator
GPM6A glycoprotein M6A
GUCY1B3 guanylate cyclase 1, soluble, beta 3
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGA1 high mobility group AT-hook 1
HOXB2 homeobox B2
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INA internexin neuronal intermediate filament protein, alpha
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KIAA0226L KIAA0226-like
LTB lymphotoxin beta (TNF superfamily, member 3)
MAN1A1 mannosidase, alpha, class 1A, member 1
MANSC1 MANSC domain containing 1
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MMP10 matrix metallopeptidase 10
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NMU neuromedin U
NSG1 neuron specific gene family member 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLAU plasminogen activator, urokinase
PLS1 plastin 1
PRAME preferentially expressed antigen in melanoma
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
QPCT glutaminyl-peptide cyclotransferase
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REG1A regenerating islet-derived 1 alpha
RGCC regulator of cell cycle
RGS10 regulator of G-protein signaling 10
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS21 ribosomal protein S21
SCG2 secretogranin II
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SNX10 sorting nexin 10
SPINT1 serine peptidase inhibitor, Kunitz type 1
SST somatostatin
ST14 suppression of tumorigenicity 14 (colon carcinoma)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TM7SF3 transmembrane 7 superfamily member 3
TMEM14B transmembrane protein 14B
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOX3 TOX high mobility group box family member 3
TPD52 tumor protein D52
TPP1 tripeptidyl peptidase I
TRHDE thyrotropin-releasing hormone degrading enzyme
VNN1 vanin 1
VWA5A von Willebrand factor A domain containing 5A
WASF1 WAS protein family, member 1

decreased expression

Symbol Name
ACBD3 acyl-CoA binding domain containing 3
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP12 A kinase (PRKA) anchor protein 12
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARID4B AT rich interactive domain 4B (RBP1-like)
ARPC5L actin related protein 2/3 complex, subunit 5-like
ASXL2 additional sex combs like transcriptional regulator 2
AURKA aurora kinase A
BARD1 BRCA1 associated RING domain 1
BLCAP bladder cancer associated protein
BRD3 bromodomain containing 3
C9ORF3 chromosome 9 open reading frame 3
CBR3 carbonyl reductase 3
CDC25B cell division cycle 25B
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4
CDC6 cell division cycle 6
CDCA4 cell division cycle associated 4
CDK7 cyclin-dependent kinase 7
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CENPA centromere protein A
CHD1 chromodomain helicase DNA binding protein 1
CLU clusterin
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CXCL12 chemokine (C-X-C motif) ligand 12
DBF4 DBF4 zinc finger
DHRS2 dehydrogenase/reductase (SDR family) member 2
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP5 dual specificity phosphatase 5
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EED embryonic ectoderm development
EFS embryonal Fyn-associated substrate
EIF5 eukaryotic translation initiation factor 5
EPHB3 EPH receptor B3
FABP4 fatty acid binding protein 4, adipocyte
FAM102A family with sequence similarity 102, member A
FBXL12 F-box and leucine-rich repeat protein 12
FOXO1 forkhead box O1
FOXO3 forkhead box O3
FZD7 frizzled class receptor 7
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPX7 glutathione peroxidase 7
GRSF1 G-rich RNA sequence binding factor 1
H1F0 H1 histone family, member 0
HK1 hexokinase 1
HMOX1 heme oxygenase 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HOXA10 homeobox A10
HOXA5 homeobox A5
HOXC6 homeobox C6
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IGFBP4 insulin-like growth factor binding protein 4
INPP1 inositol polyphosphate-1-phosphatase
JADE1 jade family PHD finger 1
JMJD6 jumonji domain containing 6
KANK1 KN motif and ankyrin repeat domains 1
KLF4 Kruppel-like factor 4 (gut)
KLHL9 kelch-like family member 9
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT7 keratin 7, type II
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MSH6 mutS homolog 6
MT1X metallothionein 1X
MYBPC1 myosin binding protein C, slow type
N4BP2L2 NEDD4 binding protein 2-like 2
NAV2 neuron navigator 2
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
OSER1 oxidative stress responsive serine-rich 1
PAX8 paired box 8
PCM1 pericentriolar material 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPAP2B phosphatidic acid phosphatase type 2B
PPIF peptidylprolyl isomerase F
PTX3 pentraxin 3, long
RAD9A RAD9 homolog A (S. pombe)
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBMS1 RNA binding motif, single stranded interacting protein 1
RPP38 ribonuclease P/MRP 38kDa subunit
RUFY3 RUN and FYVE domain containing 3
RXRA retinoid X receptor, alpha
SASH1 SAM and SH3 domain containing 1
SCGB2A2 secretoglobin, family 2A, member 2
SET SET nuclear proto-oncogene
SETD5 SET domain containing 5
SFRP1 secreted frizzled-related protein 1
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SMAD1 SMAD family member 1
SNX11 sorting nexin 11
SOBP sine oculis binding protein homolog (Drosophila)
SOX4 SRY (sex determining region Y)-box 4
SPHK1 sphingosine kinase 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TDP1 tyrosyl-DNA phosphodiesterase 1
TGFBR3 transforming growth factor, beta receptor III
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TMPO thymopoietin
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNPO1 transportin 1
TRIM29 tripartite motif containing 29
TSC22D2 TSC22 domain family, member 2
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1
UMPS uridine monophosphate synthetase
USP1 ubiquitin specific peptidase 1
VCAN versican
WAC WW domain containing adaptor with coiled-coil
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZDHHC6 zinc finger, DHHC-type containing 6
ZNF131 zinc finger protein 131