BRD-A04026261_YO-2_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-A04026261_YO-2_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
ALOX5 arachidonate 5-lipoxygenase
ARG2 arginase 2
BEX4 brain expressed, X-linked 4
BZW2 basic leucine zipper and W2 domains 2
C1ORF116 chromosome 1 open reading frame 116
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCR2 chemokine (C-C motif) receptor 2
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKM creatine kinase, muscle
CLCA2 chloride channel accessory 2
CLDN3 claudin 3
CLIC5 chloride intracellular channel 5
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCR4 chemokine (C-X-C motif) receptor 4
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DENND1B DENN/MADD domain containing 1B
DES desmin
DHCR24 24-dehydrocholesterol reductase
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ESR1 estrogen receptor 1
EXT1 exostosin glycosyltransferase 1
FABP7 fatty acid binding protein 7, brain
FAM69A family with sequence similarity 69, member A
FHL1 four and a half LIM domains 1
FILIP1L filamin A interacting protein 1-like
FN1 fibronectin 1
FRZB frizzled-related protein
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GEM GTP binding protein overexpressed in skeletal muscle
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
LDLR low density lipoprotein receptor
LOC100505650 uncharacterized LOC100505650
LPAR6 lysophosphatidic acid receptor 6
MEIS2 Meis homeobox 2
MEST mesoderm specific transcript
MMP7 matrix metallopeptidase 7
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
MZB1 marginal zone B and B1 cell-specific protein
NEB nebulin
NVL nuclear VCP-like
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
PALLD palladin, cytoskeletal associated protein
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PMM2 phosphomannomutase 2
PON3 paraoxonase 3
POU2AF1 POU class 2 associating factor 1
PRUNE2 prune homolog 2 (Drosophila)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTPRO protein tyrosine phosphatase, receptor type, O
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RTN2 reticulon 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SFRP1 secreted frizzled-related protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SHB Src homology 2 domain containing adaptor protein B
SLPI secretory leukocyte peptidase inhibitor
SOCS2 suppressor of cytokine signaling 2
SQLE squalene epoxidase
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TNNC2 troponin C type 2 (fast)
TNNT1 troponin T type 1 (skeletal, slow)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TTN titin
UBE2J1 ubiquitin-conjugating enzyme E2, J1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ACOT7 acyl-CoA thioesterase 7
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ANXA1 annexin A1
ANXA5 annexin A5
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
COL1A1 collagen, type I, alpha 1
CST3 cystatin C
CXCL8 chemokine (C-X-C motif) ligand 8
DKK1 dickkopf WNT signaling pathway inhibitor 1
DST dystonin
EGR3 early growth response 3
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GAS1 growth arrest-specific 1
GCA grancalcin, EF-hand calcium binding protein
GLDC glycine dehydrogenase (decarboxylating)
GMDS GDP-mannose 4,6-dehydratase
HACD2 3-hydroxyacyl-CoA dehydratase 2
HBB hemoglobin, beta
HOXB7 homeobox B7
HOXC6 homeobox C6
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA8 heat shock 70kDa protein 8
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KRT10 keratin 10, type I
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
NNMT nicotinamide N-methyltransferase
PFDN4 prefoldin subunit 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLS3 plastin 3
RCAN1 regulator of calcineurin 1
RPS27L ribosomal protein S27-like
SELL selectin L
SEPT11 septin 11
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORD sorbitol dehydrogenase
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TPBG trophoblast glycoprotein