BRD-A03623303_METOPROLOL TARTRATE_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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67 genes differentially expressed following the BRD-A03623303_METOPROLOL TARTRATE_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ANXA3 annexin A3
ARMCX3 armadillo repeat containing, X-linked 3
C2CD2L C2CD2-like
CDK7 cyclin-dependent kinase 7
CHPT1 choline phosphotransferase 1
CLU clusterin
CSNK1E casein kinase 1, epsilon
CSTB cystatin B (stefin B)
CXCL12 chemokine (C-X-C motif) ligand 12
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENO2 enolase 2 (gamma, neuronal)
ETNK1 ethanolamine kinase 1
FAM216A family with sequence similarity 216, member A
FUCA1 fucosidase, alpha-L- 1, tissue
HACD1 3-hydroxyacyl-CoA dehydratase 1
HACD3 3-hydroxyacyl-CoA dehydratase 3
HLF hepatic leukemia factor
IGFBP4 insulin-like growth factor binding protein 4
IL6ST interleukin 6 signal transducer
LTF lactotransferrin
MMP7 matrix metallopeptidase 7
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NRN1 neuritin 1
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRKCA protein kinase C, alpha
PTX3 pentraxin 3, long
PURA purine-rich element binding protein A
SAV1 salvador family WW domain containing protein 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5AP arachidonate 5-lipoxygenase-activating protein
AMIGO2 adhesion molecule with Ig-like domain 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPAS1 endothelial PAS domain protein 1
FXYD3 FXYD domain containing ion transport regulator 3
GAL galanin/GMAP prepropeptide
GPI glucose-6-phosphate isomerase
HIST1H2BK histone cluster 1, H2bk
IFNAR1 interferon (alpha, beta and omega) receptor 1
KIAA0196 KIAA0196
MAN2B1 mannosidase, alpha, class 2B, member 1
MIR22HG MIR22 host gene
NDRG1 N-myc downstream regulated 1
P3H2 prolyl 3-hydroxylase 2
PAPD7 PAP associated domain containing 7
PBX3 pre-B-cell leukemia homeobox 3
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RGS1 regulator of G-protein signaling 1
RTN2 reticulon 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SNX7 sorting nexin 7
SPINK1 serine peptidase inhibitor, Kazal type 1
TES testin LIM domain protein
TGFBI transforming growth factor, beta-induced, 68kDa
VDAC1 voltage-dependent anion channel 1
ZNF395 zinc finger protein 395