BRD-A03623303_METOPROLOL TARTRATE_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-A03623303_METOPROLOL TARTRATE_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABLIM1 actin binding LIM protein 1
ADGRF5 adhesion G protein-coupled receptor F5
ADM adrenomedullin
ALOX5 arachidonate 5-lipoxygenase
ARG2 arginase 2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BLNK B-cell linker
CADM1 cell adhesion molecule 1
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL4 chemokine (C-C motif) ligand 4
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CD93 CD93 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CLDN3 claudin 3
CLEC5A C-type lectin domain family 5, member A
COL11A1 collagen, type XI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CTNND1 catenin (cadherin-associated protein), delta 1
CXADR coxsackie virus and adenovirus receptor
CXCR4 chemokine (C-X-C motif) receptor 4
DOCK4 dedicator of cytokinesis 4
EMP1 epithelial membrane protein 1
FLT1 fms-related tyrosine kinase 1
FUT1 fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
GIMAP6 GTPase, IMAP family member 6
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GRB7 growth factor receptor-bound protein 7
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGL immunoglobulin lambda locus
IRF6 interferon regulatory factor 6
JAG1 jagged 1
KRT15 keratin 15, type I
KRT23 keratin 23, type I
LPAR6 lysophosphatidic acid receptor 6
LYPD3 LY6/PLAUR domain containing 3
MECOM MDS1 and EVI1 complex locus
MEF2C myocyte enhancer factor 2C
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MPZL2 myelin protein zero-like 2
MTSS1 metastasis suppressor 1
NEFH neurofilament, heavy polypeptide
NELL2 NEL-like 2 (chicken)
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
POSTN periostin, osteoblast specific factor
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRK protein tyrosine phosphatase, receptor type, K
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RTN1 reticulon 1
RTN2 reticulon 2
S100A8 S100 calcium binding protein A8
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SDC1 syndecan 1
SLC38A1 solute carrier family 38, member 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
TACSTD2 tumor-associated calcium signal transducer 2
TES testin LIM domain protein
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM30B transmembrane protein 30B
TMEM45A transmembrane protein 45A
TPD52 tumor protein D52
TRDV3 T cell receptor delta variable 3
TSPAN12 tetraspanin 12
TYROBP TYRO protein tyrosine kinase binding protein
VEGFA vascular endothelial growth factor A
ZFP36 ZFP36 ring finger protein
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
ARPC4 actin related protein 2/3 complex, subunit 4, 20kDa
C5ORF30 chromosome 5 open reading frame 30
C6ORF62 chromosome 6 open reading frame 62
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CYBA cytochrome b-245, alpha polypeptide
DCBLD2 discoidin, CUB and LCCL domain containing 2
DKK1 dickkopf WNT signaling pathway inhibitor 1
FEZ2 fasciculation and elongation protein zeta 2 (zygin II)
FOLR1 folate receptor 1 (adult)
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IL6ST interleukin 6 signal transducer
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
MSRB2 methionine sulfoxide reductase B2
MTA1 metastasis associated 1
MYH10 myosin, heavy chain 10, non-muscle
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NME4 NME/NM23 nucleoside diphosphate kinase 4
QDPR quinoid dihydropteridine reductase
RPS27L ribosomal protein S27-like
SACS sacsin molecular chaperone
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SHCBP1 SHC SH2-domain binding protein 1
SORD sorbitol dehydrogenase
SPINK1 serine peptidase inhibitor, Kazal type 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TNC tenascin C
TSPAN3 tetraspanin 3
ZCCHC24 zinc finger, CCHC domain containing 24