BRD-A03436432_NCGC00182942-03_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

169 genes differentially expressed following the BRD-A03436432_NCGC00182942-03_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ATP11B ATPase, class VI, type 11B
CADM1 cell adhesion molecule 1
CCND2 cyclin D2
CD200 CD200 molecule
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
COLEC12 collectin sub-family member 12
CORO1A coronin, actin binding protein, 1A
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CTSZ cathepsin Z
DKK3 dickkopf WNT signaling pathway inhibitor 3
DSP desmoplakin
F11R F11 receptor
FCGBP Fc fragment of IgG binding protein
FMOD fibromodulin
FN1 fibronectin 1
FRZB frizzled-related protein
FST follistatin
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
HIST1H2BG histone cluster 1, H2bg
HLA-B major histocompatibility complex, class I, B
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IGL immunoglobulin lambda locus
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
IRF6 interferon regulatory factor 6
ITGB7 integrin, beta 7
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KLK10 kallikrein-related peptidase 10
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LMO3 LIM domain only 3 (rhombotin-like 2)
MAN2A1 mannosidase, alpha, class 2A, member 1
MAOA monoamine oxidase A
MMP9 matrix metallopeptidase 9
MZB1 marginal zone B and B1 cell-specific protein
NANOG Nanog homeobox
NELL2 NEL-like 2 (chicken)
PBX3 pre-B-cell leukemia homeobox 3
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PDIA3 protein disulfide isomerase family A, member 3
PEG3 paternally expressed 3
PYCARD PYD and CARD domain containing
RAB25 RAB25, member RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RBP1 retinol binding protein 1, cellular
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SUSD4 sushi domain containing 4
TCF4 transcription factor 4
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THY1 Thy-1 cell surface antigen
TNNT1 troponin T type 1 (skeletal, slow)
TRIB1 tribbles pseudokinase 1
TXNIP thioredoxin interacting protein
ZHX2 zinc fingers and homeoboxes 2
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACOT9 acyl-CoA thioesterase 9
ACTN1 actinin, alpha 1
AGO3 argonaute RISC catalytic component 3
AHR aryl hydrocarbon receptor
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
ANXA3 annexin A3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATF1 activating transcription factor 1
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
C8ORF4 chromosome 8 open reading frame 4
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHMP4A charged multivesicular body protein 4A
CHPT1 choline phosphotransferase 1
CLIC4 chloride intracellular channel 4
CTSL cathepsin L
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DUSP10 dual specificity phosphatase 10
EBNA1BP2 EBNA1 binding protein 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPS8 epidermal growth factor receptor pathway substrate 8
ETNK1 ethanolamine kinase 1
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase)
FOLR1 folate receptor 1 (adult)
GLUD1 glutamate dehydrogenase 1
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GULP1 GULP, engulfment adaptor PTB domain containing 1
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HLTF helicase-like transcription factor
HOXB7 homeobox B7
HOXC6 homeobox C6
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA1A heat shock 70kDa protein 1A
HSPB11 heat shock protein family B (small), member 11
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IL13RA2 interleukin 13 receptor, alpha 2
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
ITGB5 integrin, beta 5
KIAA0368 KIAA0368
KIF14 kinesin family member 14
KIF2C kinesin family member 2C
KRT7 keratin 7, type II
KYNU kynureninase
LACTB2 lactamase, beta 2
LIMS1 LIM and senescent cell antigen-like domains 1
MAGEA6 melanoma antigen family A6
MAP7 microtubule-associated protein 7
MARCKS myristoylated alanine-rich protein kinase C substrate
MET MET proto-oncogene, receptor tyrosine kinase
MGLL monoglyceride lipase
MLF1 myeloid leukemia factor 1
MRPS30 mitochondrial ribosomal protein S30
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NFIB nuclear factor I/B
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NNMT nicotinamide N-methyltransferase
NPY neuropeptide Y
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PLAGL1 pleiomorphic adenoma gene-like 1
PRDX1 peroxiredoxin 1
PRPF4 pre-mRNA processing factor 4
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
QDPR quinoid dihydropteridine reductase
RAB40B RAB40B, member RAS oncogene family
RFK riboflavin kinase
RPS11 ribosomal protein S11
RPS27L ribosomal protein S27-like
SACS sacsin molecular chaperone
SF1 splicing factor 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SMS spermine synthase
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SPRY2 sprouty homolog 2 (Drosophila)
SRSF11 serine/arginine-rich splicing factor 11
STOM stomatin
SYNM synemin, intermediate filament protein
TFAM transcription factor A, mitochondrial
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
UGCG UDP-glucose ceramide glucosyltransferase
USP1 ubiquitin specific peptidase 1
USP33 ubiquitin specific peptidase 33
WBP5 WW domain binding protein 5
WWTR1 WW domain containing transcription regulator 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB18 zinc finger and BTB domain containing 18
ZNF330 zinc finger protein 330