BRD-A02481876_Importazole_VCAP_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

166 genes differentially expressed following the BRD-A02481876_Importazole_VCAP_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ALDOC aldolase C, fructose-bisphosphate
AQP1 aquaporin 1 (Colton blood group)
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATHL1 ATH1, acid trehalase-like 1 (yeast)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL3 B-cell CLL/lymphoma 3
BGN biglycan
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPG capping protein (actin filament), gelsolin-like
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CD14 CD14 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L2 chitinase 3-like 2
CHRDL1 chordin-like 1
CLEC3B C-type lectin domain family 3, member B
CLU clusterin
COL6A2 collagen, type VI, alpha 2
COMP cartilage oligomeric matrix protein
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDR1 discoidin domain receptor tyrosine kinase 1
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
FAM63A family with sequence similarity 63, member A
FMO2 flavin containing monooxygenase 2 (non-functional)
FOXO4 forkhead box O4
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPER1 G protein-coupled estrogen receptor 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
ICAM1 intercellular adhesion molecule 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGKV4-1 immunoglobulin kappa variable 4-1
INHBB inhibin, beta B
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
LDLR low density lipoprotein receptor
LUM lumican
MGP matrix Gla protein
MSMO1 methylsterol monooxygenase 1
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEBL nebulette
NUPR1 nuclear protein, transcriptional regulator, 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEG10 paternally expressed 10
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTN pleiotrophin
RBP4 retinol binding protein 4, plasma
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRAS related RAS viral (r-ras) oncogene homolog
SDC4 syndecan 4
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SGCE sarcoglycan, epsilon
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SOX4 SRY (sex determining region Y)-box 4
STK26 serine/threonine protein kinase 26
TF transferrin
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TOB1 transducer of ERBB2, 1
TPBG trophoblast glycoprotein
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TWIST1 twist family bHLH transcription factor 1
TYMP thymidine phosphorylase
VCAM1 vascular cell adhesion molecule 1
VSIG4 V-set and immunoglobulin domain containing 4
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADCY1 adenylate cyclase 1 (brain)
AKAP12 A kinase (PRKA) anchor protein 12
ANXA1 annexin A1
AQP3 aquaporin 3 (Gill blood group)
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ATXN1 ataxin 1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
CDC25A cell division cycle 25A
CFI complement factor I
COL4A5 collagen, type IV, alpha 5
CRISP3 cysteine-rich secretory protein 3
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DST dystonin
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FAM208A family with sequence similarity 208, member A
FAM208B family with sequence similarity 208, member B
FASTKD5 FAST kinase domains 5
FOXJ3 forkhead box J3
FYB FYN binding protein
GNAS GNAS complex locus
GRIA2 glutamate receptor, ionotropic, AMPA 2
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA6 integrin, alpha 6
KANK1 KN motif and ankyrin repeat domains 1
KIAA0101 KIAA0101
KRT6B keratin 6B, type II
LAMA3 laminin, alpha 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LMO2 LIM domain only 2 (rhombotin-like 1)
MACF1 microtubule-actin crosslinking factor 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MMP9 matrix metallopeptidase 9
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCK1 NCK adaptor protein 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
PDHX pyruvate dehydrogenase complex, component X
PI3 peptidase inhibitor 3, skin-derived
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PODXL podocalyxin-like
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLIRP SRA stem-loop interacting RNA binding protein
TBC1D4 TBC1 domain family, member 4
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TKT transketolase
TRIM24 tripartite motif containing 24
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TYRP1 tyrosinase-related protein 1
UBE3C ubiquitin protein ligase E3C
UBR5 ubiquitin protein ligase E3 component n-recognin 5
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae)
ZC3HAV1 zinc finger CCCH-type, antiviral 1