BRD-A02481876_Importazole_VCAP_24.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

233 genes differentially expressed following the BRD-A02481876_Importazole_VCAP_24.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
CALCOCO1 calcium binding and coiled-coil domain 1
CAPG capping protein (actin filament), gelsolin-like
CD24 CD24 molecule
CD9 CD9 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL11A1 collagen, type XI, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSRNP2 cysteine-serine-rich nuclear protein 2
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTGF connective tissue growth factor
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP3 dual specificity phosphatase 3
EFHD1 EF-hand domain family, member D1
EMP1 epithelial membrane protein 1
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
EXT1 exostosin glycosyltransferase 1
FAM129A family with sequence similarity 129, member A
FOXO3 forkhead box O3
FRY furry homolog (Drosophila)
GAS6 growth arrest-specific 6
GDI1 GDP dissociation inhibitor 1
GEM GTP binding protein overexpressed in skeletal muscle
GLA galactosidase, alpha
GLUL glutamate-ammonia ligase
GPM6B glycoprotein M6B
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HOMER3 homer scaffolding protein 3
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
INPP1 inositol polyphosphate-1-phosphatase
IRF9 interferon regulatory factor 9
KLHL24 kelch-like family member 24
LMO4 LIM domain only 4
LST1 leukocyte specific transcript 1
MMP12 matrix metallopeptidase 12
MT1E metallothionein 1E
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MTMR11 myotubularin related protein 11
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
PBX1 pre-B-cell leukemia homeobox 1
PEA15 phosphoprotein enriched in astrocytes 15
PLVAP plasmalemma vesicle associated protein
POGK pogo transposable element with KRAB domain
PPAP2B phosphatidic acid phosphatase type 2B
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
S100A13 S100 calcium binding protein A13
SCGB2A2 secretoglobin, family 2A, member 2
SERINC3 serine incorporator 3
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
STK38L serine/threonine kinase 38 like
TF transferrin
TGFBI transforming growth factor, beta-induced, 68kDa
TIMP1 TIMP metallopeptidase inhibitor 1
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACAT1 acetyl-CoA acetyltransferase 1
ADCY1 adenylate cyclase 1 (brain)
AKAP7 A kinase (PRKA) anchor protein 7
AMD1 adenosylmethionine decarboxylase 1
ANAPC1 anaphase promoting complex subunit 1
ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP5G3 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
ATP5S ATP synthase, H+ transporting, mitochondrial Fo complex, subunit s (factor B)
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BLMH bleomycin hydrolase
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C14ORF2 chromosome 14 open reading frame 2
CASP7 caspase 7, apoptosis-related cysteine peptidase
CCL19 chemokine (C-C motif) ligand 19
CCNA2 cyclin A2
CENPE centromere protein E, 312kDa
CFI complement factor I
CHEK2 checkpoint kinase 2
CKS2 CDC28 protein kinase regulatory subunit 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CTPS1 CTP synthase 1
CXCL14 chemokine (C-X-C motif) ligand 14
DCXR dicarbonyl/L-xylulose reductase
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEGS1 delta(4)-desaturase, sphingolipid 1
DHRS11 dehydrogenase/reductase (SDR family) member 11
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4E eukaryotic translation initiation factor 4E
EIF5A eukaryotic translation initiation factor 5A
ENDOD1 endonuclease domain containing 1
ETFB electron-transfer-flavoprotein, beta polypeptide
EVL Enah/Vasp-like
EXOSC4 exosome component 4
FABP1 fatty acid binding protein 1, liver
FAS Fas cell surface death receptor
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
GHR growth hormone receptor
GRSF1 G-rich RNA sequence binding factor 1
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HOMER2 homer scaffolding protein 2
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPA8 heat shock 70kDa protein 8
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IGLL1 immunoglobulin lambda-like polypeptide 1
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KIF5C kinesin family member 5C
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMA3 laminin, alpha 3
LEF1 lymphoid enhancer-binding factor 1
LIMS1 LIM and senescent cell antigen-like domains 1
LOC100505650 uncharacterized LOC100505650
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAOB monoamine oxidase B
MAP7 microtubule-associated protein 7
MAST2 microtubule associated serine/threonine kinase 2
MBNL1 muscleblind-like splicing regulator 1
MELK maternal embryonic leucine zipper kinase
MGST2 microsomal glutathione S-transferase 2
MPC2 mitochondrial pyruvate carrier 2
MRPL12 mitochondrial ribosomal protein L12
MRPL23 mitochondrial ribosomal protein L23
MRPL3 mitochondrial ribosomal protein L3
MRPS16 mitochondrial ribosomal protein S16
MRPS33 mitochondrial ribosomal protein S33
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP MYC binding protein
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit
NCALD neurocalcin delta
NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa
NDUFC1 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMU neuromedin U
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NR2F2 nuclear receptor subfamily 2, group F, member 2
OGFOD3 2-oxoglutarate and iron-dependent oxygenase domain containing 3
OXCT1 3-oxoacid CoA transferase 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PAM peptidylglycine alpha-amidating monooxygenase
PBK PDZ binding kinase
PCCB propionyl CoA carboxylase, beta polypeptide
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDZRN3 PDZ domain containing ring finger 3
PIGP phosphatidylinositol glycan anchor biosynthesis, class P
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLK1 polo-like kinase 1
PPA1 pyrophosphatase (inorganic) 1
PRDX2 peroxiredoxin 2
PRDX4 peroxiredoxin 4
PSD3 pleckstrin and Sec7 domain containing 3
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3
RHOBTB3 Rho-related BTB domain containing 3
RPS21 ribosomal protein S21
SCARB1 scavenger receptor class B, member 1
SKP1 S-phase kinase-associated protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLIRP SRA stem-loop interacting RNA binding protein
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMC4 structural maintenance of chromosomes 4
SMS spermine synthase
SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 16kDa
SORD sorbitol dehydrogenase
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SSBP1 single-stranded DNA binding protein 1, mitochondrial
ST7 suppression of tumorigenicity 7
STK39 serine threonine kinase 39
TARP TCR gamma alternate reading frame protein
TBC1D4 TBC1 domain family, member 4
TCF4 transcription factor 4
TIMM13 translocase of inner mitochondrial membrane 13 homolog (yeast)
TRIM14 tripartite motif containing 14
TRIM24 tripartite motif containing 24
TRIP13 thyroid hormone receptor interactor 13
TSPAN8 tetraspanin 8
TUSC3 tumor suppressor candidate 3
TXN thioredoxin
UBXN8 UBX domain protein 8
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
UXS1 UDP-glucuronate decarboxylase 1
WDR61 WD repeat domain 61