BRD-A02481876_Importazole_SW620_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

153 genes differentially expressed following the BRD-A02481876_Importazole_SW620_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANKRD10 ankyrin repeat domain 10
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BEX1 brain expressed, X-linked 1
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CAST calpastatin
CCL2 chemokine (C-C motif) ligand 2
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHN1 chimerin 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CPA3 carboxypeptidase A3 (mast cell)
CXADR coxsackie virus and adenovirus receptor
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EIF5 eukaryotic translation initiation factor 5
FADS1 fatty acid desaturase 1
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
H1F0 H1 histone family, member 0
HAL histidine ammonia-lyase
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST3H2A histone cluster 3, H2a
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOXA5 homeobox A5
INHBE inhibin, beta E
KRT18 keratin 18, type I
KRT6B keratin 6B, type II
LDLR low density lipoprotein receptor
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARCKSL1 MARCKS-like 1
MARS methionyl-tRNA synthetase
MMP1 matrix metallopeptidase 1
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSAT1 phosphoserine aminotransferase 1
RIOK3 RIO kinase 3
RND3 Rho family GTPase 3
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A2 solute carrier family 38, member 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SPON2 spondin 2, extracellular matrix protein
STC2 stanniocalcin 2
SYBU syntabulin (syntaxin-interacting)
TESC tescalcin
TGIF1 TGFB-induced factor homeobox 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TST thiosulfate sulfurtransferase (rhodanese)
TXNIP thioredoxin interacting protein
TXNL4B thioredoxin-like 4B
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
ZNF195 zinc finger protein 195

decreased expression

Symbol Name
ADCY9 adenylate cyclase 9
ADGRL2 adhesion G protein-coupled receptor L2
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATXN1 ataxin 1
AURKA aurora kinase A
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2
CD200 CD200 molecule
CDC42 cell division cycle 42
CHD9 chromodomain helicase DNA binding protein 9
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
COL9A3 collagen, type IX, alpha 3
COPS7A COP9 signalosome subunit 7A
CST7 cystatin F (leukocystatin)
CTPS1 CTP synthase 1
CXCL14 chemokine (C-X-C motif) ligand 14
CYTL1 cytokine-like 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHB2 EPH receptor B2
FOLR1 folate receptor 1 (adult)
FYN FYN proto-oncogene, Src family tyrosine kinase
GOLGA4 golgin A4
GRB14 growth factor receptor-bound protein 14
GRWD1 glutamate-rich WD repeat containing 1
GSN gelsolin
HAPLN1 hyaluronan and proteoglycan link protein 1
HOMER2 homer scaffolding protein 2
HSPA1A heat shock 70kDa protein 1A
IGF1R insulin-like growth factor 1 receptor
IL1RN interleukin 1 receptor antagonist
KANK1 KN motif and ankyrin repeat domains 1
KAZN kazrin, periplakin interacting protein
KIAA0101 KIAA0101
KRT4 keratin 4, type II
MBNL1 muscleblind-like splicing regulator 1
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MMP9 matrix metallopeptidase 9
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRPS28 mitochondrial ribosomal protein S28
MTERF3 mitochondrial transcription termination factor 3
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
NSF N-ethylmaleimide-sensitive factor
NUSAP1 nucleolar and spindle associated protein 1
ODAM odontogenic, ameloblast asssociated
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDZK1 PDZ domain containing 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSD3 pleckstrin and Sec7 domain containing 3
PTDSS1 phosphatidylserine synthase 1
QPRT quinolinate phosphoribosyltransferase
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RGS1 regulator of G-protein signaling 1
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMAD6 SMAD family member 6
SMAD7 SMAD family member 7
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
ST7 suppression of tumorigenicity 7
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF4 transcription factor 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TM9SF2 transmembrane 9 superfamily member 2
TOP2A topoisomerase (DNA) II alpha 170kDa
WIF1 WNT inhibitory factor 1
WWTR1 WW domain containing transcription regulator 1