BRD-A02481876_Importazole_SW480_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-A02481876_Importazole_SW480_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACPP acid phosphatase, prostate
ADIRF adipogenesis regulatory factor
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
AREG amphiregulin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG3 BCL2-associated athanogene 3
BCL3 B-cell CLL/lymphoma 3
BTG1 B-cell translocation gene 1, anti-proliferative
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLTC clathrin, heavy chain (Hc)
COL15A1 collagen, type XV, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
DDIT4 DNA-damage-inducible transcript 4
DOCK4 dedicator of cytokinesis 4
DPYSL3 dihydropyrimidinase-like 3
DUSP3 dual specificity phosphatase 3
DUSP5 dual specificity phosphatase 5
EFNA1 ephrin-A1
EGR3 early growth response 3
EIF5 eukaryotic translation initiation factor 5
EMP1 epithelial membrane protein 1
FN1 fibronectin 1
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GBP1 guanylate binding protein 1, interferon-inducible
GNAS GNAS complex locus
GPM6B glycoprotein M6B
GPX3 glutathione peroxidase 3
H1F0 H1 histone family, member 0
HIST1H2BG histone cluster 1, H2bg
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA2 heat shock 70kDa protein 2
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER2 immediate early response 2
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IL1R1 interleukin 1 receptor, type I
INSIG1 insulin induced gene 1
IRF1 interferon regulatory factor 1
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KLHL21 kelch-like family member 21
KLK10 kallikrein-related peptidase 10
KRT19 keratin 19, type I
LGALS3 lectin, galactoside-binding, soluble, 3
MAP7 microtubule-associated protein 7
MMP12 matrix metallopeptidase 12
MPO myeloperoxidase
MSMB microseminoprotein, beta-
MT1M metallothionein 1M
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PLAU plasminogen activator, urokinase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RNF167 ring finger protein 167
S100A10 S100 calcium binding protein A10
S100A2 S100 calcium binding protein A2
SCRG1 stimulator of chondrogenesis 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SELE selectin E
SFN stratifin
SLC38A2 solute carrier family 38, member 2
SNAI2 snail family zinc finger 2
STAT1 signal transducer and activator of transcription 1, 91kDa
STX1A syntaxin 1A (brain)
TACSTD2 tumor-associated calcium signal transducer 2
TGM4 transglutaminase 4
TICAM1 toll-like receptor adaptor molecule 1
TUBB2A tubulin, beta 2A class IIa
ZFP36 ZFP36 ring finger protein
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF586 zinc finger protein 586

decreased expression

Symbol Name
ACSL1 acyl-CoA synthetase long-chain family member 1
ALCAM activated leukocyte cell adhesion molecule
ASPN asporin
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AUTS2 autism susceptibility candidate 2
BCL2 B-cell CLL/lymphoma 2
BEX1 brain expressed, X-linked 1
BMP4 bone morphogenetic protein 4
CA12 carbonic anhydrase XII
CCNB2 cyclin B2
COL4A5 collagen, type IV, alpha 5
CPB1 carboxypeptidase B1 (tissue)
CPVL carboxypeptidase, vitellogenic-like
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
DMXL2 Dmx-like 2
DUSP1 dual specificity phosphatase 1
FKBP5 FK506 binding protein 5
GSAP gamma-secretase activating protein
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HIGD2A HIG1 hypoxia inducible domain family, member 2A
HOXC10 homeobox C10
IGHM immunoglobulin heavy constant mu
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
IKZF1 IKAROS family zinc finger 1 (Ikaros)
IQGAP2 IQ motif containing GTPase activating protein 2
KIAA0101 KIAA0101
KIAA0355 KIAA0355
KLHL2 kelch-like family member 2
MAOB monoamine oxidase B
MDK midkine (neurite growth-promoting factor 2)
MEGF9 multiple EGF-like-domains 9
METTL7A methyltransferase like 7A
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NQO1 NAD(P)H dehydrogenase, quinone 1
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OXA1L oxidase (cytochrome c) assembly 1-like
PCSK6 proprotein convertase subtilisin/kexin type 6
PIAS1 protein inhibitor of activated STAT, 1
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP prolactin-induced protein
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PSPH phosphoserine phosphatase
RAB4A RAB4A, member RAS oncogene family
RGS4 regulator of G-protein signaling 4
RRAGD Ras-related GTP binding D
SDC2 syndecan 2
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
SYT1 synaptotagmin I
TAGLN transgelin
TBC1D4 TBC1 domain family, member 4
TCF4 transcription factor 4
TIAM1 T-cell lymphoma invasion and metastasis 1
TLR4 toll-like receptor 4
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1
VSNL1 visinin-like 1