BRD-A02481876_Importazole_SNGM_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

145 genes differentially expressed following the BRD-A02481876_Importazole_SNGM_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ALOX5 arachidonate 5-lipoxygenase
APOD apolipoprotein D
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCL8 chemokine (C-C motif) ligand 8
CD48 CD48 molecule
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CELF2 CUGBP, Elav-like family member 2
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL15A1 collagen, type XV, alpha 1
CPE carboxypeptidase E
CRISP3 cysteine-rich secretory protein 3
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CSTA cystatin A (stefin A)
CYB5R1 cytochrome b5 reductase 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DPT dermatopontin
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GSTM3 glutathione S-transferase mu 3 (brain)
H1FX H1 histone family, member X
H2AFY H2A histone family, member Y
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
ITM2A integral membrane protein 2A
KCTD5 potassium channel tetramerization domain containing 5
KDM5D lysine (K)-specific demethylase 5D
KLF4 Kruppel-like factor 4 (gut)
LAMP2 lysosomal-associated membrane protein 2
MFSD10 major facilitator superfamily domain containing 10
NEU1 sialidase 1 (lysosomal sialidase)
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PDLIM3 PDZ and LIM domain 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIE peptidylprolyl isomerase E (cyclophilin E)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SESN1 sestrin 1
SNAI2 snail family zinc finger 2
SRPX sushi-repeat containing protein, X-linked
STC2 stanniocalcin 2
THY1 Thy-1 cell surface antigen
TMEM134 transmembrane protein 134
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
UBL5 ubiquitin-like 5

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AMD1 adenosylmethionine decarboxylase 1
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ASCC3 activating signal cointegrator 1 complex subunit 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BPTF bromodomain PHD finger transcription factor
CA12 carbonic anhydrase XII
CA2 carbonic anhydrase II
CCNG1 cyclin G1
CDK1 cyclin-dependent kinase 1
CDK6 cyclin-dependent kinase 6
COX11 COX11 cytochrome c oxidase copper chaperone
CXCR4 chemokine (C-X-C motif) receptor 4
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DNTT DNA nucleotidylexotransferase
DPYSL2 dihydropyrimidinase-like 2
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
EIF5B eukaryotic translation initiation factor 5B
EREG epiregulin
FASTKD1 FAST kinase domains 1
FOXJ3 forkhead box J3
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GRB10 growth factor receptor-bound protein 10
GRB14 growth factor receptor-bound protein 14
HMGA2 high mobility group AT-hook 2
HOXA10 homeobox A10
HOXA5 homeobox A5
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IPO5 importin 5
ITGA6 integrin, alpha 6
JAG1 jagged 1
JMJD6 jumonji domain containing 6
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LAMB1 laminin, beta 1
LEFTY1 left-right determination factor 1
LIMS1 LIM and senescent cell antigen-like domains 1
LRRC16A leucine rich repeat containing 16A
MALT1 MALT1 paracaspase
MAP2K6 mitogen-activated protein kinase kinase 6
MET MET proto-oncogene, receptor tyrosine kinase
MLEC malectin
MMP1 matrix metallopeptidase 1
MMP10 matrix metallopeptidase 10
MRPL42 mitochondrial ribosomal protein L42
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYH10 myosin, heavy chain 10, non-muscle
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative)
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NREP neuronal regeneration related protein
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPA1 pyrophosphatase (inorganic) 1
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTX3 pentraxin 3, long
QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1
RAB13 RAB13, member RAS oncogene family
RGS13 regulator of G-protein signaling 13
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFPQ splicing factor proline/glutamine-rich
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STAT1 signal transducer and activator of transcription 1, 91kDa
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
THBS1 thrombospondin 1
TKT transketolase
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM22 tripartite motif containing 22
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17
VCAN versican
VRK2 vaccinia related kinase 2
WWTR1 WW domain containing transcription regulator 1
ZMIZ1 zinc finger, MIZ-type containing 1