BRD-A02481876_Importazole_SKLU1_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

164 genes differentially expressed following the BRD-A02481876_Importazole_SKLU1_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AREG amphiregulin
ATF3 activating transcription factor 3
BAALC brain and acute leukemia, cytoplasmic
BEX4 brain expressed, X-linked 4
BTG2 BTG family, member 2
CCR2 chemokine (C-C motif) receptor 2
CD36 CD36 molecule (thrombospondin receptor)
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
COL11A1 collagen, type XI, alpha 1
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CYB561 cytochrome b561
CYTIP cytohesin 1 interacting protein
DEPTOR DEP domain containing MTOR-interacting protein
DPT dermatopontin
DSC3 desmocollin 3
DUSP6 dual specificity phosphatase 6
EAPP E2F-associated phosphoprotein
EGR2 early growth response 2
EPYC epiphycan
FBXO11 F-box protein 11
FBXO2 F-box protein 2
FHL1 four and a half LIM domains 1
FZD6 frizzled class receptor 6
GAS1 growth arrest-specific 1
GLA galactosidase, alpha
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GYG2 glycogenin 2
HES1 hes family bHLH transcription factor 1
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
KRT14 keratin 14, type I
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MFAP5 microfibrillar associated protein 5
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NR1H2 nuclear receptor subfamily 1, group H, member 2
NSG1 neuron specific gene family member 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PERP PERP, TP53 apoptosis effector
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POSTN periostin, osteoblast specific factor
PRNP prion protein
PTN pleiotrophin
RGCC regulator of cell cycle
RLN2 relaxin 2
SCG2 secretogranin II
SCGB1D2 secretoglobin, family 1D, member 2
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
STK26 serine/threonine protein kinase 26
SULF1 sulfatase 1
TCEAL2 transcription elongation factor A (SII)-like 2
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TM7SF2 transmembrane 7 superfamily member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM4 tropomyosin 4
TRIM2 tripartite motif containing 2
TRIM29 tripartite motif containing 29
TSC22D3 TSC22 domain family, member 3
VTCN1 V-set domain containing T cell activation inhibitor 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACSL5 acyl-CoA synthetase long-chain family member 5
ADCY9 adenylate cyclase 9
AP2B1 adaptor-related protein complex 2, beta 1 subunit
ARID4B AT rich interactive domain 4B (RBP1-like)
B3GNT1
BASP1 brain abundant, membrane attached signal protein 1
CCND2 cyclin D2
CD58 CD58 molecule
CDC42 cell division cycle 42
CDYL chromodomain protein, Y-like
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPA centromere protein A
CEP170 centrosomal protein 170kDa
CEP350 centrosomal protein 350kDa
CHN2 chimerin 2
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
COL4A2 collagen, type IV, alpha 2
COL4A5 collagen, type IV, alpha 5
CXCL6 chemokine (C-X-C motif) ligand 6
DICER1 dicer 1, ribonuclease type III
DOCK9 dedicator of cytokinesis 9
DUOX2 dual oxidase 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FKBP10 FK506 binding protein 10, 65 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FOXJ3 forkhead box J3
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GSAP gamma-secretase activating protein
HMGA2 high mobility group AT-hook 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA8 heat shock 70kDa protein 8
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGF1R insulin-like growth factor 1 receptor
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAMP1 lysosomal-associated membrane protein 1
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LBR lamin B receptor
LMNB1 lamin B1
MED1 mediator complex subunit 1
MET MET proto-oncogene, receptor tyrosine kinase
NET1 neuroepithelial cell transforming 1
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
NKTR natural killer cell triggering receptor
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NR2F2 nuclear receptor subfamily 2, group F, member 2
PDGFA platelet-derived growth factor alpha polypeptide
PHF20 PHD finger protein 20
PLBD1 phospholipase B domain containing 1
PLXNA2 plexin A2
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
PRSS2 protease, serine, 2 (trypsin 2)
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RFC2 replication factor C (activator 1) 2, 40kDa
RHOBTB3 Rho-related BTB domain containing 3
RREB1 ras responsive element binding protein 1
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
SETD5 SET domain containing 5
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SMAD3 SMAD family member 3
SNTB2 syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
SOD2 superoxide dismutase 2, mitochondrial
SVIL supervillin
SYNE1 spectrin repeat containing, nuclear envelope 1
TBC1D4 TBC1 domain family, member 4
TFF3 trefoil factor 3 (intestinal)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TIA1 TIA1 cytotoxic granule-associated RNA binding protein
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TNPO1 transportin 1
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE3C ubiquitin protein ligase E3C
UBN1 ubinuclein 1
UGCG UDP-glucose ceramide glucosyltransferase
WDR82 WD repeat domain 82
WNT5A wingless-type MMTV integration site family, member 5A
ZBTB38 zinc finger and BTB domain containing 38
ZC3H4 zinc finger CCCH-type containing 4
ZEB1 zinc finger E-box binding homeobox 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYND8 zinc finger, MYND-type containing 8