BRD-A02481876_Importazole_RMUGS_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

89 genes differentially expressed following the BRD-A02481876_Importazole_RMUGS_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANPEP alanyl (membrane) aminopeptidase
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C8ORF4 chromosome 8 open reading frame 4
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCH1 GTP cyclohydrolase 1
GLDC glycine dehydrogenase (decarboxylating)
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HMOX1 heme oxygenase 1
KLF2 Kruppel-like factor 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MTSS1 metastasis suppressor 1
NAV3 neuron navigator 3
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PER1 period circadian clock 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTX3 pentraxin 3, long
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC39A4 solute carrier family 39 (zinc transporter), member 4
SNAI2 snail family zinc finger 2
TMEM45A transmembrane protein 45A
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
VCAM1 vascular cell adhesion molecule 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
CRABP2 cellular retinoic acid binding protein 2
CSRP2 cysteine and glycine-rich protein 2
DENND1B DENN/MADD domain containing 1B
DNM1L dynamin 1-like
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FN1 fibronectin 1
FZD2 frizzled class receptor 2
GUSBP3 glucuronidase, beta pseudogene 3
HILPDA hypoxia inducible lipid droplet-associated
HMGA2 high mobility group AT-hook 2
IFI27 interferon, alpha-inducible protein 27
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
IVNS1ABP influenza virus NS1A binding protein
JCHAIN joining chain of multimeric IgA and IgM
KDM3A lysine (K)-specific demethylase 3A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
LOC100505650 uncharacterized LOC100505650
MDK midkine (neurite growth-promoting factor 2)
MECOM MDS1 and EVI1 complex locus
PTK2 protein tyrosine kinase 2
QPRT quinolinate phosphoribosyltransferase
RGS5 regulator of G-protein signaling 5
RIN2 Ras and Rab interactor 2
RTN2 reticulon 2
SPRR3 small proline-rich protein 3
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TKT transketolase
ZIC1 Zic family member 1
ZNF652 zinc finger protein 652