BRD-A02481876_Importazole_PL21_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

216 genes differentially expressed following the BRD-A02481876_Importazole_PL21_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACP5 acid phosphatase 5, tartrate resistant
ADGRG1 adhesion G protein-coupled receptor G1
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG3 BTG family, member 3
C3ORF14 chromosome 3 open reading frame 14
CAV1 caveolin 1, caveolae protein, 22kDa
CD24 CD24 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL15A1 collagen, type XV, alpha 1
CPE carboxypeptidase E
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL9 chemokine (C-X-C motif) ligand 9
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYTIP cytohesin 1 interacting protein
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPYSL3 dihydropyrimidinase-like 3
EGFL6 EGF-like-domain, multiple 6
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP4 fatty acid binding protein 4, adipocyte
FBLN1 fibulin 1
FBXL12 F-box and leucine-rich repeat protein 12
FHL1 four and a half LIM domains 1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GDF15 growth differentiation factor 15
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GSTT1 glutathione S-transferase theta 1
H1FX H1 histone family, member X
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXD1 homeobox D1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IDO1 indoleamine 2,3-dioxygenase 1
IDUA iduronidase, alpha-L-
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGFBP5 insulin-like growth factor binding protein 5
IGHM immunoglobulin heavy constant mu
INA internexin neuronal intermediate filament protein, alpha
ISG15 ISG15 ubiquitin-like modifier
JUN jun proto-oncogene
KDR kinase insert domain receptor
KLF6 Kruppel-like factor 6
KRT8 keratin 8, type II
LCN2 lipocalin 2
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LPAR6 lysophosphatidic acid receptor 6
MARCKS myristoylated alanine-rich protein kinase C substrate
MMP12 matrix metallopeptidase 12
MYOF myoferlin
NUAK1 NUAK family, SNF1-like kinase, 1
NUPR1 nuclear protein, transcriptional regulator, 1
OASL 2'-5'-oligoadenylate synthetase-like
PDLIM3 PDZ and LIM domain 3
PEG10 paternally expressed 10
PELI1 pellino E3 ubiquitin protein ligase 1
PLBD1 phospholipase B domain containing 1
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLVAP plasmalemma vesicle associated protein
PLXNB2 plexin B2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PON3 paraoxonase 3
PPAP2A phosphatidic acid phosphatase type 2A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
QPCT glutaminyl-peptide cyclotransferase
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RHOB ras homolog family member B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RSAD2 radical S-adenosyl methionine domain containing 2
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SDC1 syndecan 1
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT10 septin 10
SGCE sarcoglycan, epsilon
SGK1 serum/glucocorticoid regulated kinase 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SPINK1 serine peptidase inhibitor, Kazal type 1
ST18 suppression of tumorigenicity 18, zinc finger
STAT1 signal transducer and activator of transcription 1, 91kDa
STC1 stanniocalcin 1
SULF1 sulfatase 1
TBCC tubulin folding cofactor C
TERF1 telomeric repeat binding factor (NIMA-interacting) 1
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
TOB1 transducer of ERBB2, 1
TPD52 tumor protein D52
TSC22D3 TSC22 domain family, member 3
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
TWIST1 twist family bHLH transcription factor 1
WDR45 WD repeat domain 45
XIST X inactive specific transcript (non-protein coding)
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AK2 adenylate kinase 2
ALCAM activated leukocyte cell adhesion molecule
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
APOC2 apolipoprotein C-II
ARMC8 armadillo repeat containing 8
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa
ASCC3 activating signal cointegrator 1 complex subunit 3
ASXL2 additional sex combs like transcriptional regulator 2
ATP13A3 ATPase type 13A3
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
AZU1 azurocidin 1
BCL2 B-cell CLL/lymphoma 2
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX1 brain expressed, X-linked 1
CAB39 calcium binding protein 39
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND2 cyclin D2
CDC20 cell division cycle 20
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDK19 cyclin-dependent kinase 19
CENPE centromere protein E, 312kDa
CENPF centromere protein F, 350/400kDa
CHMP4A charged multivesicular body protein 4A
CLTC clathrin, heavy chain (Hc)
COG2 component of oligomeric golgi complex 2
CTSG cathepsin G
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLG1 discs, large homolog 1 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
ERG v-ets avian erythroblastosis virus E26 oncogene homolog
FOXJ3 forkhead box J3
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GBE1 glucan (1,4-alpha-), branching enzyme 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA8 heat shock 70kDa protein 8
IPO5 importin 5
KAT6A K(lysine) acetyltransferase 6A
KDM5D lysine (K)-specific demethylase 5D
KIAA0391 KIAA0391
LAPTM5 lysosomal protein transmembrane 5
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LBR lamin B receptor
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MBNL1 muscleblind-like splicing regulator 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTF2 metal response element binding transcription factor 2
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYO10 myosin X
MYO6 myosin VI
NNMT nicotinamide N-methyltransferase
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NPY neuropeptide Y
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NSF N-ethylmaleimide-sensitive factor
NUDCD3 NudC domain containing 3
PARP1 poly (ADP-ribose) polymerase 1
PCCB propionyl CoA carboxylase, beta polypeptide
PLAC8 placenta-specific 8
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha
PRKCA protein kinase C, alpha
PRKCB protein kinase C, beta
PTDSS1 phosphatidylserine synthase 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RGS4 regulator of G-protein signaling 4
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STK24 serine/threonine kinase 24
TM9SF2 transmembrane 9 superfamily member 2
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMEM100 transmembrane protein 100
TMEM87A transmembrane protein 87A
TMF1 TATA element modulatory factor 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TRAPPC3 trafficking protein particle complex 3
TSEN2 TSEN2 tRNA splicing endonuclease subunit
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UBE3C ubiquitin protein ligase E3C
VRK1 vaccinia related kinase 1
WIPF2 WAS/WASL interacting protein family, member 2