BRD-A02481876_Importazole_PC3_24.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

246 genes differentially expressed following the BRD-A02481876_Importazole_PC3_24.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADIRF adipogenesis regulatory factor
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ALDOB aldolase B, fructose-bisphosphate
ALDOC aldolase C, fructose-bisphosphate
ANGPTL2 angiopoietin-like 2
APOD apolipoprotein D
ARID5B AT rich interactive domain 5B (MRF1-like)
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BTG1 B-cell translocation gene 1, anti-proliferative
BTG3 BTG family, member 3
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
CCDC92 coiled-coil domain containing 92
CCL20 chemokine (C-C motif) ligand 20
CCL8 chemokine (C-C motif) ligand 8
CCNL1 cyclin L1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEMIP cell migration inducing protein, hyaluronan binding
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLC Charcot-Leyden crystal galectin
CLDN1 claudin 1
CLDND1 claudin domain containing 1
CLEC2B C-type lectin domain family 2, member B
CLU clusterin
CPA3 carboxypeptidase A3 (mast cell)
CRIP1 cysteine-rich protein 1 (intestinal)
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL8 chemokine (C-X-C motif) ligand 8
CYBRD1 cytochrome b reductase 1
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EDN1 endothelin 1
EIF1B eukaryotic translation initiation factor 1B
EML3 echinoderm microtubule associated protein like 3
EMP1 epithelial membrane protein 1
FAM131A family with sequence similarity 131, member A
GBP2 guanylate binding protein 2, interferon-inducible
GCH1 GTP cyclohydrolase 1
GNPDA1 glucosamine-6-phosphate deaminase 1
GPX7 glutathione peroxidase 7
HCP5 HLA complex P5 (non-protein coding)
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
JOSD1 Josephin domain containing 1
JUND jun D proto-oncogene
KLF11 Kruppel-like factor 11
KLHL24 kelch-like family member 24
LGALS4 lectin, galactoside-binding, soluble, 4
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA1 melanoma antigen family A1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP5 microfibrillar associated protein 5
MMD monocyte to macrophage differentiation-associated
MMP19 matrix metallopeptidase 19
MOAP1 modulator of apoptosis 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PELI1 pellino E3 ubiquitin protein ligase 1
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAF2 PRA1 domain family, member 2
PTN pleiotrophin
PTPRO protein tyrosine phosphatase, receptor type, O
RAB11FIP1 RAB11 family interacting protein 1 (class I)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
REG1A regenerating islet-derived 1 alpha
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RSRP1 arginine/serine-rich protein 1
RUNDC3A RUN domain containing 3A
SEPP1 selenoprotein P, plasma, 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SOD2 superoxide dismutase 2, mitochondrial
SST somatostatin
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STX3 syntaxin 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
WDR45 WD repeat domain 45
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTN1 actinin, alpha 1
ADK adenosine kinase
AIM1 absent in melanoma 1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF6 activating transcription factor 6
AURKA aurora kinase A
BASP1 brain abundant, membrane attached signal protein 1
BBX bobby sox homolog (Drosophila)
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B
C16ORF45 chromosome 16 open reading frame 45
CA12 carbonic anhydrase XII
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CAST calpastatin
CCNA2 cyclin A2
CCNB1 cyclin B1
CCND2 cyclin D2
CD44 CD44 molecule (Indian blood group)
CDCA3 cell division cycle associated 3
CDCA4 cell division cycle associated 4
CDKN3 cyclin-dependent kinase inhibitor 3
CENPF centromere protein F, 350/400kDa
CEP350 centrosomal protein 350kDa
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHD9 chromodomain helicase DNA binding protein 9
CNOT7 CCR4-NOT transcription complex, subunit 7
COL4A2 collagen, type IV, alpha 2
COTL1 coactosin-like F-actin binding protein 1
CPD carboxypeptidase D
CSE1L CSE1 chromosome segregation 1-like (yeast)
DAAM1 dishevelled associated activator of morphogenesis 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EFNB2 ephrin-B2
ELAVL1 ELAV like RNA binding protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPHB2 EPH receptor B2
EXT1 exostosin glycosyltransferase 1
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial
FBN2 fibrillin 2
FN1 fibronectin 1
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GNAQ guanine nucleotide binding protein (G protein), q polypeptide
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMGA2 high mobility group AT-hook 2
HNRNPA3 heterogeneous nuclear ribonucleoprotein A3
HOXA10 homeobox A10
IGFBP7 insulin-like growth factor binding protein 7
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
ITGA6 integrin, alpha 6
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KCTD12 potassium channel tetramerization domain containing 12
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LAMA3 laminin, alpha 3
LAMC1 laminin, gamma 1 (formerly LAMB2)
LARS2 leucyl-tRNA synthetase 2, mitochondrial
LGALS1 lectin, galactoside-binding, soluble, 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LMNB1 lamin B1
LOXL1 lysyl oxidase-like 1
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MACF1 microtubule-actin crosslinking factor 1
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MBNL1 muscleblind-like splicing regulator 1
MCM3 minichromosome maintenance complex component 3
MCM6 minichromosome maintenance complex component 6
MLPH melanophilin
MNAT1 MNAT CDK-activating kinase assembly factor 1
MRPS28 mitochondrial ribosomal protein S28
MSRA methionine sulfoxide reductase A
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYO10 myosin X
NCALD neurocalcin delta
NEBL nebulette
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
NRP1 neuropilin 1
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PBK PDZ binding kinase
PBX3 pre-B-cell leukemia homeobox 3
PDLIM5 PDZ and LIM domain 5
PFN2 profilin 2
PHKB phosphorylase kinase, beta
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRC1 protein regulator of cytokinesis 1
PRKCA protein kinase C, alpha
PSRC1 proline/serine-rich coiled-coil 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTTG1 pituitary tumor-transforming 1
RAI14 retinoic acid induced 14
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RUVBL1 RuvB-like AAA ATPase 1
SCARB1 scavenger receptor class B, member 1
SDC1 syndecan 1
SEPT9 septin 9
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPATS2L spermatogenesis associated, serine-rich 2-like
SPDEF SAM pointed domain containing ETS transcription factor
SUCLG2 succinate-CoA ligase, GDP-forming, beta subunit
SVIL supervillin
TACC3 transforming, acidic coiled-coil containing protein 3
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI2 tissue factor pathway inhibitor 2
TJP2 tight junction protein 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM131 transmembrane protein 131
TOP2A topoisomerase (DNA) II alpha 170kDa
TOX3 TOX high mobility group box family member 3
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TTK TTK protein kinase
TUBA4A tubulin, alpha 4a
UTRN utrophin
VRK1 vaccinia related kinase 1
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
XPO7 exportin 7
ZMYND8 zinc finger, MYND-type containing 8
ZWILCH zwilch kinetochore protein
ZWINT ZW10 interacting kinetochore protein