BRD-A02481876_Importazole_NCIH596_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

134 genes differentially expressed following the BRD-A02481876_Importazole_NCIH596_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
AREG amphiregulin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BHLHE40 basic helix-loop-helix family, member e40
BTG1 B-cell translocation gene 1, anti-proliferative
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCND2 cyclin D2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHMP2B charged multivesicular body protein 2B
CLDN1 claudin 1
COL15A1 collagen, type XV, alpha 1
COL1A1 collagen, type I, alpha 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHRS2 dehydrogenase/reductase (SDR family) member 2
DPT dermatopontin
DUSP4 dual specificity phosphatase 4
DUSP6 dual specificity phosphatase 6
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM129A family with sequence similarity 129, member A
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
FST follistatin
GADD45A growth arrest and DNA-damage-inducible, alpha
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
GDPD3 glycerophosphodiester phosphodiesterase domain containing 3
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GRN granulin
H1F0 H1 histone family, member 0
H2AFV H2A histone family, member V
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HSPA13 heat shock protein 70kDa family, member 13
IGF1R insulin-like growth factor 1 receptor
INHBA inhibin, beta A
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NFIL3 nuclear factor, interleukin 3 regulated
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PI3 peptidase inhibitor 3, skin-derived
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPARG peroxisome proliferator-activated receptor gamma
RBP4 retinol binding protein 4, plasma
RBPMS RNA binding protein with multiple splicing
RGCC regulator of cell cycle
S100P S100 calcium binding protein P
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SLC38A1 solute carrier family 38, member 1
SNAI2 snail family zinc finger 2
SPARCL1 SPARC-like 1 (hevin)
SPATS2L spermatogenesis associated, serine-rich 2-like
SPHK1 sphingosine kinase 1
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SRP72 signal recognition particle 72kDa
STK17A serine/threonine kinase 17a
TARS threonyl-tRNA synthetase
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB3 tribbles pseudokinase 3
UPP1 uridine phosphorylase 1
VGLL4 vestigial-like family member 4
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
AK1 adenylate kinase 1
AKAP7 A kinase (PRKA) anchor protein 7
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATP6V0E2 ATPase, H+ transporting V0 subunit e2
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BEX1 brain expressed, X-linked 1
C3 complement component 3
CCNA2 cyclin A2
CCR2 chemokine (C-C motif) receptor 2
CDKN2A cyclin-dependent kinase inhibitor 2A
CFI complement factor I
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLU clusterin
CSRP1 cysteine and glycine-rich protein 1
CX3CR1 chemokine (C-X3-C motif) receptor 1
CYBB cytochrome b-245, beta polypeptide
DCN decorin
DEFB1 defensin, beta 1
ELANE elastase, neutrophil expressed
FAM198B family with sequence similarity 198, member B
FLI1 Fli-1 proto-oncogene, ETS transcription factor
GFAP glial fibrillary acidic protein
GNAS GNAS complex locus
GPM6A glycoprotein M6A
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBB hemoglobin, beta
HSPA1A heat shock 70kDa protein 1A
IFI44L interferon-induced protein 44-like
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
LIMCH1 LIM and calponin homology domains 1
LTBP2 latent transforming growth factor beta binding protein 2
MEGF9 multiple EGF-like-domains 9
MFAP3L microfibrillar-associated protein 3-like
MNDA myeloid cell nuclear differentiation antigen
MTSS1 metastasis suppressor 1
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NOTCH2 notch 2
PMP2 peripheral myelin protein 2
PRPF4 pre-mRNA processing factor 4
PTGDS prostaglandin D2 synthase 21kDa (brain)
RTN3 reticulon 3
S100A8 S100 calcium binding protein A8
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SORD sorbitol dehydrogenase
TF transferrin
TLR4 toll-like receptor 4
TMPO thymopoietin
TPD52L1 tumor protein D52-like 1
TRIM22 tripartite motif containing 22
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican
ZEB2 zinc finger E-box binding homeobox 2