BRD-A02481876_Importazole_NCIH1836_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A02481876_Importazole_NCIH1836_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AEBP1 AE binding protein 1
ALDOC aldolase C, fructose-bisphosphate
ATF3 activating transcription factor 3
BAMBI BMP and activin membrane-bound inhibitor
BCHE butyrylcholinesterase
BMP2 bone morphogenetic protein 2
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CFB complement factor B
CLC Charcot-Leyden crystal galectin
COL11A1 collagen, type XI, alpha 1
COL16A1 collagen, type XVI, alpha 1
COMP cartilage oligomeric matrix protein
CSAD cysteine sulfinic acid decarboxylase
CTGF connective tissue growth factor
CXCR4 chemokine (C-X-C motif) receptor 4
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
GFPT1 glutamine--fructose-6-phosphate transaminase 1
HEBP1 heme binding protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGHM immunoglobulin heavy constant mu
IGKV3-20 immunoglobulin kappa variable 3-20
IGLV3-19 immunoglobulin lambda variable 3-19
IRS2 insulin receptor substrate 2
KLF4 Kruppel-like factor 4 (gut)
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A
MSLN mesothelin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
PCDH7 protocadherin 7
PER1 period circadian clock 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PXDN peroxidasin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RPL10 ribosomal protein L10
S100P S100 calcium binding protein P
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERP1 stress-associated endoplasmic reticulum protein 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIK1 salt-inducible kinase 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SULF1 sulfatase 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
TMEM45A transmembrane protein 45A
TPBG trophoblast glycoprotein
XBP1 X-box binding protein 1
ZFP36L1 ZFP36 ring finger protein-like 1

decreased expression

Symbol Name
ABLIM1 actin binding LIM protein 1
ADCY1 adenylate cyclase 1 (brain)
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APLP2 amyloid beta (A4) precursor-like protein 2
ARHGAP32 Rho GTPase activating protein 32
ARID4B AT rich interactive domain 4B (RBP1-like)
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
BEX1 brain expressed, X-linked 1
CA2 carbonic anhydrase II
CENPF centromere protein F, 350/400kDa
CEP170 centrosomal protein 170kDa
CLCA4 chloride channel accessory 4
CLTC clathrin, heavy chain (Hc)
COCH cochlin
COL1A2 collagen, type I, alpha 2
CXCL14 chemokine (C-X-C motif) ligand 14
DARS aspartyl-tRNA synthetase
DLD dihydrolipoamide dehydrogenase
DPP8 dipeptidyl-peptidase 8
ELOVL5 ELOVL fatty acid elongase 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EVL Enah/Vasp-like
FASTKD5 FAST kinase domains 5
FGFR1 fibroblast growth factor receptor 1
FKBP1A FK506 binding protein 1A, 12kDa
FN1 fibronectin 1
FRYL FRY-like
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HOXA5 homeobox A5
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGL immunoglobulin lambda locus
ITPKB inositol-trisphosphate 3-kinase B
KRT5 keratin 5, type II
LBR lamin B receptor
LMO2 LIM domain only 2 (rhombotin-like 1)
MFHAS1 malignant fibrous histiocytoma amplified sequence 1
MGLL monoglyceride lipase
MREG melanoregulin
NFIB nuclear factor I/B
NTS neurotensin
PSIP1 PC4 and SFRS1 interacting protein 1
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic)
RHCG Rh family, C glycoprotein
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TFF3 trefoil factor 3 (intestinal)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIAM1 T-cell lymphoma invasion and metastasis 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TOR1A torsin family 1, member A (torsin A)
TXNRD1 thioredoxin reductase 1
UBE3C ubiquitin protein ligase E3C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
ZBTB18 zinc finger and BTB domain containing 18