BRD-A02481876_Importazole_NCIH1694_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

120 genes differentially expressed following the BRD-A02481876_Importazole_NCIH1694_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ADIRF adipogenesis regulatory factor
ADM adrenomedullin
ARL4A ADP-ribosylation factor-like 4A
ATF3 activating transcription factor 3
CA2 carbonic anhydrase II
CAV1 caveolin 1, caveolae protein, 22kDa
CCL4 chemokine (C-C motif) ligand 4
CCL8 chemokine (C-C motif) ligand 8
CCNE2 cyclin E2
CD40 CD40 molecule, TNF receptor superfamily member 5
CFB complement factor B
COL11A1 collagen, type XI, alpha 1
COL6A3 collagen, type VI, alpha 3
CXCL8 chemokine (C-X-C motif) ligand 8
DSP desmoplakin
EMP3 epithelial membrane protein 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
FN1 fibronectin 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GBP2 guanylate binding protein 2, interferon-inducible
GCLC glutamate-cysteine ligase, catalytic subunit
GLT8D2 glycosyltransferase 8 domain containing 2
GRAMD3 GRAM domain containing 3
GSTM3 glutathione S-transferase mu 3 (brain)
HIST1H1C histone cluster 1, H1c
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
IGFBP5 insulin-like growth factor binding protein 5
IGKV4-1 immunoglobulin kappa variable 4-1
IRS1 insulin receptor substrate 1
JUN jun proto-oncogene
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
KYNU kynureninase
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3 lectin, galactoside-binding, soluble, 3
LITAF lipopolysaccharide-induced TNF factor
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMP12 matrix metallopeptidase 12
MT1E metallothionein 1E
MT1M metallothionein 1M
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NID2 nidogen 2 (osteonidogen)
NR4A2 nuclear receptor subfamily 4, group A, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPR1 nuclear protein, transcriptional regulator, 1
P3H2 prolyl 3-hydroxylase 2
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PLAU plasminogen activator, urokinase
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RGCC regulator of cell cycle
RPL39L ribosomal protein L39-like
SAT1 spermidine/spermine N1-acetyltransferase 1
SFRP4 secreted frizzled-related protein 4
SGK1 serum/glucocorticoid regulated kinase 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
STC2 stanniocalcin 2
SULF1 sulfatase 1
TDO2 tryptophan 2,3-dioxygenase
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMEM47 transmembrane protein 47
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPM2 tropomyosin 2 (beta)
VCAM1 vascular cell adhesion molecule 1
XIST X inactive specific transcript (non-protein coding)
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ANK2 ankyrin 2, neuronal
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
CALR calreticulin
CDC20 cell division cycle 20
CEP170 centrosomal protein 170kDa
CHD7 chromodomain helicase DNA binding protein 7
CHGB chromogranin B
COCH cochlin
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CSRP2 cysteine and glycine-rich protein 2
DAAM1 dishevelled associated activator of morphogenesis 1
DACH1 dachshund family transcription factor 1
DYRK2 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
EVL Enah/Vasp-like
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
GNAS GNAS complex locus
HSPA8 heat shock 70kDa protein 8
LMO2 LIM domain only 2 (rhombotin-like 1)
MAB21L1 mab-21-like 1 (C. elegans)
MAB21L2 mab-21-like 2 (C. elegans)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
NAP1L1 nucleosome assembly protein 1-like 1
NFIB nuclear factor I/B
PAX5 paired box 5
PDLIM1 PDZ and LIM domain 1
PLCB4 phospholipase C, beta 4
PNMAL1 paraneoplastic Ma antigen family-like 1
RBP1 retinol binding protein 1, cellular
RELN reelin
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100B S100 calcium binding protein B
SAMD4A sterile alpha motif domain containing 4A
SOBP sine oculis binding protein homolog (Drosophila)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SRPX sushi-repeat containing protein, X-linked
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TRIM33 tripartite motif containing 33
TUBB2B tubulin, beta 2B class IIb
UBE3C ubiquitin protein ligase E3C
VCAN versican
ZMYM2 zinc finger, MYM-type 2