BRD-A02481876_Importazole_MDST8_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

179 genes differentially expressed following the BRD-A02481876_Importazole_MDST8_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ADIPOQ adiponectin, C1Q and collagen domain containing
ADIRF adipogenesis regulatory factor
ANKRD10 ankyrin repeat domain 10
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATHL1 ATH1, acid trehalase-like 1 (yeast)
C10ORF10 chromosome 10 open reading frame 10
CCNG2 cyclin G2
CD14 CD14 molecule
CD58 CD58 molecule
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLDN3 claudin 3
CLDN7 claudin 7
CRYAB crystallin, alpha B
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
EMX2 empty spiracles homeobox 2
FABP4 fatty acid binding protein 4, adipocyte
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FHL1 four and a half LIM domains 1
FRY furry homolog (Drosophila)
FXYD3 FXYD domain containing ion transport regulator 3
GADD45A growth arrest and DNA-damage-inducible, alpha
GAGE3 G antigen 3
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GIMAP6 GTPase, IMAP family member 6
HAPLN1 hyaluronan and proteoglycan link protein 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HOOK2 hook microtubule-tethering protein 2
HOXB7 homeobox B7
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP6 insulin-like growth factor binding protein 6
ITM2A integral membrane protein 2A
KLHL24 kelch-like family member 24
KRT7 keratin 7, type II
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
LGALS4 lectin, galactoside-binding, soluble, 4
LPAR6 lysophosphatidic acid receptor 6
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAN1A1 mannosidase, alpha, class 1A, member 1
METTL7A methyltransferase like 7A
MFAP5 microfibrillar associated protein 5
MSLN mesothelin
NFIL3 nuclear factor, interleukin 3 regulated
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDGFRL platelet-derived growth factor receptor-like
PDLIM3 PDZ and LIM domain 3
PLA2G16 phospholipase A2, group XVI
PLS1 plastin 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNP purine nucleoside phosphorylase
PROM1 prominin 1
PSCA prostate stem cell antigen
PSPH phosphoserine phosphatase
PTGIS prostaglandin I2 (prostacyclin) synthase
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBP4 retinol binding protein 4, plasma
RCAN1 regulator of calcineurin 1
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNASE4 ribonuclease, RNase A family, 4
SCGB2A1 secretoglobin, family 2A, member 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPP1 secreted phosphoprotein 1
ST18 suppression of tumorigenicity 18, zinc finger
TESC tescalcin
TICAM1 toll-like receptor adaptor molecule 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNNT1 troponin T type 1 (skeletal, slow)
TOB1 transducer of ERBB2, 1
TSPAN7 tetraspanin 7
TSPAN8 tetraspanin 8
UBQLN2 ubiquilin 2
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ALCAM activated leukocyte cell adhesion molecule
ARID4B AT rich interactive domain 4B (RBP1-like)
CALD1 caldesmon 1
CAST calpastatin
CAV1 caveolin 1, caveolae protein, 22kDa
CCL2 chemokine (C-C motif) ligand 2
CCNA1 cyclin A1
CCNB1 cyclin B1
CCND2 cyclin D2
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CH25H cholesterol 25-hydroxylase
CHD9 chromodomain helicase DNA binding protein 9
CHMP4A charged multivesicular body protein 4A
CLCA2 chloride channel accessory 2
CLTC clathrin, heavy chain (Hc)
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL4A5 collagen, type IV, alpha 5
COL5A1 collagen, type V, alpha 1
COL6A3 collagen, type VI, alpha 3
CPA3 carboxypeptidase A3 (mast cell)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FABP7 fatty acid binding protein 7, brain
FBLN1 fibulin 1
FBN2 fibrillin 2
FLRT2 fibronectin leucine rich transmembrane protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GSAP gamma-secretase activating protein
HMGA2 high mobility group AT-hook 2
HP haptoglobin
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
JARID2 jumonji, AT rich interactive domain 2
KAT6A K(lysine) acetyltransferase 6A
KCNK3 potassium channel, two pore domain subfamily K, member 3
KCTD3 potassium channel tetramerization domain containing 3
KDM5D lysine (K)-specific demethylase 5D
KIAA1033 KIAA1033
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
LEF1 lymphoid enhancer-binding factor 1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MALT1 MALT1 paracaspase
MAN2A1 mannosidase, alpha, class 2A, member 1
MAP1B microtubule-associated protein 1B
MED13 mediator complex subunit 13
MLPH melanophilin
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MYH10 myosin, heavy chain 10, non-muscle
MYO10 myosin X
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRIP1 nuclear receptor interacting protein 1
PBX3 pre-B-cell leukemia homeobox 3
PHACTR2 phosphatase and actin regulator 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PLXNC1 plexin C1
PRRC2C proline-rich coiled-coil 2C
PSD3 pleckstrin and Sec7 domain containing 3
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
RAB38 RAB38, member RAS oncogene family
RAD51C RAD51 paralog C
RRM2 ribonucleotide reductase M2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC35F2 solute carrier family 35, member F2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SVIL supervillin
TGFBI transforming growth factor, beta-induced, 68kDa
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TMF1 TATA element modulatory factor 1
TNC tenascin C
TNPO1 transportin 1
TYRP1 tyrosinase-related protein 1
UBE3C ubiquitin protein ligase E3C
VCAN versican
VSNL1 visinin-like 1
WWTR1 WW domain containing transcription regulator 1
ZMIZ1 zinc finger, MIZ-type containing 1