BRD-A02481876_Importazole_MCF7_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-A02481876_Importazole_MCF7_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ABHD4 abhydrolase domain containing 4
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ADORA2B adenosine A2b receptor
ALB albumin
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
AREG amphiregulin
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BEX4 brain expressed, X-linked 4
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
CADM1 cell adhesion molecule 1
CAPN2 calpain 2, (m/II) large subunit
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CGRRF1 cell growth regulator with ring finger domain 1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLEC11A C-type lectin domain family 11, member A
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR24 24-dehydrocholesterol reductase
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFNA1 ephrin-A1
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
ENO2 enolase 2 (gamma, neuronal)
EPHA2 EPH receptor A2
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FAM63A family with sequence similarity 63, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
GRN granulin
HBEGF heparin-binding EGF-like growth factor
HCP5 HLA complex P5 (non-protein coding)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
IER2 immediate early response 2
IER3 immediate early response 3
IFITM1 interferon induced transmembrane protein 1
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
ISG20 interferon stimulated exonuclease gene 20kDa
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
LIF leukemia inhibitory factor
LMNA lamin A/C
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MCL1 myeloid cell leukemia 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MOXD1 monooxygenase, DBH-like 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MXRA7 matrix-remodelling associated 7
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFL neurofilament, light polypeptide
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PABPN1 poly(A) binding protein, nuclear 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLK3 polo-like kinase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKP polynucleotide kinase 3'-phosphatase
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RGS3 regulator of G-protein signaling 3
RHOB ras homolog family member B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
S100A6 S100 calcium binding protein A6
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG5 secretogranin V
SDC4 syndecan 4
SIK1 salt-inducible kinase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SOX9 SRY (sex determining region Y)-box 9
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TSC22D3 TSC22 domain family, member 3
UPP1 uridine phosphorylase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
AURKA aurora kinase A
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCLAF1 BCL2-associated transcription factor 1
CA12 carbonic anhydrase XII
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC25A cell division cycle 25A
CENPF centromere protein F, 350/400kDa
CEP350 centrosomal protein 350kDa
CLCN3 chloride channel, voltage-sensitive 3
CNOT4 CCR4-NOT transcription complex, subunit 4
CREBBP CREB binding protein
CUX1 cut-like homeobox 1
CXCL5 chemokine (C-X-C motif) ligand 5
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
EMX2 empty spiracles homeobox 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ESR1 estrogen receptor 1
FAM208A family with sequence similarity 208, member A
FASTKD5 FAST kinase domains 5
GATA3 GATA binding protein 3
GRIA2 glutamate receptor, ionotropic, AMPA 2
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HIST1H2BG histone cluster 1, H2bg
HSPB8 heat shock 22kDa protein 8
IGF1R insulin-like growth factor 1 receptor
INTS3 integrator complex subunit 3
KAT6A K(lysine) acetyltransferase 6A
KAT6B K(lysine) acetyltransferase 6B
KIAA0485 uncharacterized LOC57235
KIDINS220 kinase D-interacting substrate, 220kDa
KIF14 kinesin family member 14
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
MAP7 microtubule-associated protein 7
MECOM MDS1 and EVI1 complex locus
MKI67 marker of proliferation Ki-67
MKL2 MKL/myocardin-like 2
MYH10 myosin, heavy chain 10, non-muscle
NCOA3 nuclear receptor coactivator 3
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
PBX1 pre-B-cell leukemia homeobox 1
PHACTR2 phosphatase and actin regulator 2
PHIP pleckstrin homology domain interacting protein
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PODXL podocalyxin-like
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKCD protein kinase C, delta
PRRC2C proline-rich coiled-coil 2C
PTK2 protein tyrosine kinase 2
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
S100A8 S100 calcium binding protein A8
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SFPQ splicing factor proline/glutamine-rich
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SPTBN1 spectrin, beta, non-erythrocytic 1
TBC1D4 TBC1 domain family, member 4
TCF4 transcription factor 4
TFF1 trefoil factor 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM100 transmembrane protein 100
TMEM47 transmembrane protein 47
TOP2B topoisomerase (DNA) II beta 180kDa
TRIM24 tripartite motif containing 24
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN12 tetraspanin 12
TSPAN13 tetraspanin 13
TSPAN7 tetraspanin 7
UBR5 ubiquitin protein ligase E3 component n-recognin 5
USP6NL USP6 N-terminal like
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
WNT5A wingless-type MMTV integration site family, member 5A
ZC3H4 zinc finger CCCH-type containing 4
ZC3HAV1 zinc finger CCCH-type, antiviral 1
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYM2 zinc finger, MYM-type 2
ZMYND8 zinc finger, MYND-type containing 8