BRD-A02481876_Importazole_MCF7_24.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

387 genes differentially expressed following the BRD-A02481876_Importazole_MCF7_24.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADORA2B adenosine A2b receptor
ANGPTL2 angiopoietin-like 2
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
AREG amphiregulin
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BIK BCL2-interacting killer (apoptosis-inducing)
BMP2 bone morphogenetic protein 2
BSG basigin (Ok blood group)
BTG2 BTG family, member 2
BTG3 BTG family, member 3
C9ORF16 chromosome 9 open reading frame 16
CADM1 cell adhesion molecule 1
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CD9 CD9 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CES2 carboxylesterase 2
CHGB chromogranin B
CLC Charcot-Leyden crystal galectin
CLEC11A C-type lectin domain family 11, member A
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSK cathepsin K
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
CYBRD1 cytochrome b reductase 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DMPK dystrophia myotonica-protein kinase
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
ECM1 extracellular matrix protein 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGR1 early growth response 1
EGR2 early growth response 2
EMP3 epithelial membrane protein 3
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETHE1 ethylmalonic encephalopathy 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FERMT1 fermitin family member 1
FLNA filamin A, alpha
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GATA6 GATA binding protein 6
GEM GTP binding protein overexpressed in skeletal muscle
GUK1 guanylate kinase 1
HBB hemoglobin, beta
HBEGF heparin-binding EGF-like growth factor
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IER5 immediate early response 5
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INSM1 insulinoma-associated 1
ISG15 ISG15 ubiquitin-like modifier
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
JAG1 jagged 1
JUNB jun B proto-oncogene
KCTD13 potassium channel tetramerization domain containing 13
KCTD5 potassium channel tetramerization domain containing 5
KDM6B lysine (K)-specific demethylase 6B
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KRT16 keratin 16, type I
LAMP3 lysosomal-associated membrane protein 3
LIF leukemia inhibitory factor
LMNA lamin A/C
LSR lipolysis stimulated lipoprotein receptor
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MFAP5 microfibrillar associated protein 5
MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
MMP19 matrix metallopeptidase 19
MSN moesin
MT1E metallothionein 1E
MT1G metallothionein 1G
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NPTX2 neuronal pentraxin II
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
PAEP progestagen-associated endometrial protein
PDLIM3 PDZ and LIM domain 3
PDLIM7 PDZ and LIM domain 7 (enigma)
PELI1 pellino E3 ubiquitin protein ligase 1
PERP PERP, TP53 apoptosis effector
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRNP prion protein
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPRO protein tyrosine phosphatase, receptor type, O
PTRF polymerase I and transcript release factor
R3HDM4 R3H domain containing 4
RALGDS ral guanine nucleotide dissociation stimulator
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100A2 S100 calcium binding protein A2
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SIK1 salt-inducible kinase 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SST somatostatin
TDO2 tryptophan 2,3-dioxygenase
TGFA transforming growth factor, alpha
TGFB1I1 transforming growth factor beta 1 induced transcript 1
THY1 Thy-1 cell surface antigen
TKTL1 transketolase-like 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor
VEGFA vascular endothelial growth factor A
WDR45 WD repeat domain 45
YIPF3 Yip1 domain family, member 3
ZBED2 zinc finger, BED-type containing 2
ZDHHC11 zinc finger, DHHC-type containing 11
ZFP36 ZFP36 ring finger protein
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADNP activity-dependent neuroprotector homeobox
AKAP7 A kinase (PRKA) anchor protein 7
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMD1 adenosylmethionine decarboxylase 1
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARID1A AT rich interactive domain 1A (SWI-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ASF1A anti-silencing function 1A histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
ATAD2 ATPase family, AAA domain containing 2
ATF6 activating transcription factor 6
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
AURKA aurora kinase A
B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
B3GNT1
BARD1 BRCA1 associated RING domain 1
BAZ2B bromodomain adjacent to zinc finger domain, 2B
BBX bobby sox homolog (Drosophila)
BCLAF1 BCL2-associated transcription factor 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BLM Bloom syndrome, RecQ helicase-like
BMPR1A bone morphogenetic protein receptor, type IA
BRCA1 breast cancer 1, early onset
BRIP1 BRCA1 interacting protein C-terminal helicase 1
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C2CD5 C2 calcium-dependent domain containing 5
CA12 carbonic anhydrase XII
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CCNA2 cyclin A2
CD58 CD58 molecule
CDC123 cell division cycle 123
CDC25A cell division cycle 25A
CDK19 cyclin-dependent kinase 19
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP350 centrosomal protein 350kDa
CFI complement factor I
CLINT1 clathrin interactor 1
CLTC clathrin, heavy chain (Hc)
CNOT4 CCR4-NOT transcription complex, subunit 4
COG5 component of oligomeric golgi complex 5
COIL coilin
CP ceruloplasmin (ferroxidase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DHTKD1 dehydrogenase E1 and transketolase domain containing 1
DLD dihydrolipoamide dehydrogenase
DLG1 discs, large homolog 1 (Drosophila)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ECD ecdysoneless homolog (Drosophila)
EFCAB11 EF-hand calcium binding domain 11
ELOVL2 ELOVL fatty acid elongase 2
ELOVL6 ELOVL fatty acid elongase 6
EMP2 epithelial membrane protein 2
ERBB2IP erbb2 interacting protein
ESR1 estrogen receptor 1
FAM208A family with sequence similarity 208, member A
FAM208B family with sequence similarity 208, member B
FANCI Fanconi anemia, complementation group I
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
GMDS GDP-mannose 4,6-dehydratase
HAT1 histone acetyltransferase 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HEY2 hes-related family bHLH transcription factor with YRPW motif 2
HLTF helicase-like transcription factor
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HSPA8 heat shock 70kDa protein 8
IGF1R insulin-like growth factor 1 receptor
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
INTS3 integrator complex subunit 3
IRX5 iroquois homeobox 5
JARID2 jumonji, AT rich interactive domain 2
KAT6B K(lysine) acetyltransferase 6B
KIAA0101 KIAA0101
KIAA0485 uncharacterized LOC57235
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
KYNU kynureninase
LAMC1 laminin, gamma 1 (formerly LAMB2)
LARP4B La ribonucleoprotein domain family, member 4B
LIMS1 LIM and senescent cell antigen-like domains 1
LMNB1 lamin B1
LMO2 LIM domain only 2 (rhombotin-like 1)
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
MAP2K6 mitogen-activated protein kinase kinase 6
MBNL1 muscleblind-like splicing regulator 1
MBNL2 muscleblind-like splicing regulator 2
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MEGF9 multiple EGF-like-domains 9
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MKL2 MKL/myocardin-like 2
MPZL1 myelin protein zero-like 1
MREG melanoregulin
MSH2 mutS homolog 2
MSRB2 methionine sulfoxide reductase B2
MUC1 mucin 1, cell surface associated
MYB v-myb avian myeloblastosis viral oncogene homolog
MYH10 myosin, heavy chain 10, non-muscle
NBN nibrin
NCOA3 nuclear receptor coactivator 3
NMD3 NMD3 ribosome export adaptor
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMI N-myc (and STAT) interactor
NNT nicotinamide nucleotide transhydrogenase
NOL11 nucleolar protein 11
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRIP1 nuclear receptor interacting protein 1
NUP85 nucleoporin 85kDa
OXTR oxytocin receptor
PBK PDZ binding kinase
PCMT1 protein-L-isoaspartate (D-aspartate) O-methyltransferase
PDS5A PDS5 cohesin associated factor A
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2
PEX3 peroxisomal biogenesis factor 3
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PITRM1 pitrilysin metallopeptidase 1
PLAC8 placenta-specific 8
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PLK4 polo-like kinase 4
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PPP1R12A protein phosphatase 1, regulatory subunit 12A
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRC1 protein regulator of cytokinesis 1
PROM1 prominin 1
PRPF4B pre-mRNA processing factor 4B
PRRC2C proline-rich coiled-coil 2C
PRSS23 protease, serine, 23
PTK2 protein tyrosine kinase 2
PUM2 pumilio RNA-binding family member 2
RACGAP1 Rac GTPase activating protein 1
RBBP4 retinoblastoma binding protein 4
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RREB1 ras responsive element binding protein 1
SCAF8 SR-related CTD-associated factor 8
SCYL3 SCY1-like 3 (S. cerevisiae)
SEPHS1 selenophosphate synthetase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SFPQ splicing factor proline/glutamine-rich
SHOC2 soc-2 suppressor of clear homolog (C. elegans)
SKIV2L2 superkiller viralicidic activity 2-like 2 (S. cerevisiae)
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMC4 structural maintenance of chromosomes 4
SNX1 sorting nexin 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SPTBN1 spectrin, beta, non-erythrocytic 1
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
ST7 suppression of tumorigenicity 7
STX7 syntaxin 7
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D4 TBC1 domain family, member 4
TBL1X transducin (beta)-like 1X-linked
TCF12 transcription factor 12
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK1 tousled-like kinase 1
TMEM135 transmembrane protein 135
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TOP2B topoisomerase (DNA) II beta 180kDa
TPD52L1 tumor protein D52-like 1
TRPS1 trichorhinophalangeal syndrome I
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSKU tsukushi, small leucine rich proteoglycan
TSPYL5 TSPY-like 5
TTK TTK protein kinase
TUBB tubulin, beta class I
TXNDC9 thioredoxin domain containing 9
UBE3C ubiquitin protein ligase E3C
UBL3 ubiquitin-like 3
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP34 ubiquitin specific peptidase 34
USP6NL USP6 N-terminal like
USP9X ubiquitin specific peptidase 9, X-linked
VRK1 vaccinia related kinase 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
XPO1 exportin 1
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZC3H13 zinc finger CCCH-type containing 13
ZC3H4 zinc finger CCCH-type containing 4
ZMYND11 zinc finger, MYND-type containing 11
ZMYND8 zinc finger, MYND-type containing 8
ZWILCH zwilch kinetochore protein