BRD-A02481876_Importazole_LOVO_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-A02481876_Importazole_LOVO_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BGN biglycan
BHLHE41 basic helix-loop-helix family, member e41
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C9ORF16 chromosome 9 open reading frame 16
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD52 CD52 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CIRBP cold inducible RNA binding protein
CLEC7A C-type lectin domain family 7, member A
COL1A1 collagen, type I, alpha 1
CSTA cystatin A (stefin A)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DAP death-associated protein
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EGR2 early growth response 2
EGR3 early growth response 3
EIF5A eukaryotic translation initiation factor 5A
FAM46A family with sequence similarity 46, member A
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPX3 glutathione peroxidase 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB1 heat shock 27kDa protein 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
INHBA inhibin, beta A
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF2 Kruppel-like factor 2
KRT17 keratin 17, type I
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MMP7 matrix metallopeptidase 7
MSMB microseminoprotein, beta-
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
OSER1 oxidative stress responsive serine-rich 1
PCBP2 poly(rC) binding protein 2
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAT plasminogen activator, tissue
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRAF2 PRA1 domain family, member 2
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
S100A2 S100 calcium binding protein A2
SCAND1 SCAN domain containing 1
SCG2 secretogranin II
SDC4 syndecan 4
SFN stratifin
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
TAGLN2 transgelin 2
THBS2 thrombospondin 2
TMEM45A transmembrane protein 45A
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TNIP1 TNFAIP3 interacting protein 1
TOB1 transducer of ERBB2, 1
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
VAV3 vav 3 guanine nucleotide exchange factor
VCAN versican
VIM vimentin

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADAM9 ADAM metallopeptidase domain 9
AFF1 AF4/FMR2 family, member 1
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5
CDK19 cyclin-dependent kinase 19
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPF centromere protein F, 350/400kDa
CLTC clathrin, heavy chain (Hc)
CRABP2 cellular retinoic acid binding protein 2
ENDOD1 endonuclease domain containing 1
ERBB3 erb-b2 receptor tyrosine kinase 3
EXOSC4 exosome component 4
FKBP1B FK506 binding protein 1B, 12.6 kDa
FOXJ3 forkhead box J3
GALC galactosylceramidase
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GPRC5A G protein-coupled receptor, class C, group 5, member A
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
HOXC10 homeobox C10
KANK2 KN motif and ankyrin repeat domains 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIF14 kinesin family member 14
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MET MET proto-oncogene, receptor tyrosine kinase
MKL2 MKL/myocardin-like 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEFH neurofilament, heavy polypeptide
OLFM1 olfactomedin 1
PAXIP1 PAX interacting (with transcription-activation domain) protein 1
PBK PDZ binding kinase
PFN2 profilin 2
PLAC8 placenta-specific 8
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PSD3 pleckstrin and Sec7 domain containing 3
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RGL1 ral guanine nucleotide dissociation stimulator-like 1
ROCK2 Rho-associated, coiled-coil containing protein kinase 2
RREB1 ras responsive element binding protein 1
SASH1 SAM and SH3 domain containing 1
SHROOM2 shroom family member 2
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCF4 transcription factor 4
TCL1A T-cell leukemia/lymphoma 1A
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TP53BP2 tumor protein p53 binding protein 2
UBE3C ubiquitin protein ligase E3C
UBL3 ubiquitin-like 3
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
VSNL1 visinin-like 1