BRD-A02481876_Importazole_JHUEM2_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

189 genes differentially expressed following the BRD-A02481876_Importazole_JHUEM2_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGTR1 angiotensin II receptor, type 1
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
BEX4 brain expressed, X-linked 4
BHLHE41 basic helix-loop-helix family, member e41
BLNK B-cell linker
BTG3 BTG family, member 3
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CD163 CD163 molecule
CD44 CD44 molecule (Indian blood group)
CD52 CD52 molecule
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL11A1 collagen, type XI, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYTIP cytohesin 1 interacting protein
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
DERL1 derlin 1
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32)
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FSD1 fibronectin type III and SPRY domain containing 1
FXYD6 FXYD domain containing ion transport regulator 6
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GNLY granulysin
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1)
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGL immunoglobulin lambda locus
IL10RA interleukin 10 receptor, alpha
ISG15 ISG15 ubiquitin-like modifier
JAM2 junctional adhesion molecule 2
JCHAIN joining chain of multimeric IgA and IgM
JUN jun proto-oncogene
KRT14 keratin 14, type I
LRRC15 leucine rich repeat containing 15
LYZ lysozyme
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFAP5 microfibrillar associated protein 5
MSLN mesothelin
MUC16 mucin 16, cell surface associated
NR4A2 nuclear receptor subfamily 4, group A, member 2
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OASL 2'-5'-oligoadenylate synthetase-like
PARP2 poly (ADP-ribose) polymerase 2
PCCB propionyl CoA carboxylase, beta polypeptide
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDE2A phosphodiesterase 2A, cGMP-stimulated
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PLAU plasminogen activator, urokinase
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PTN pleiotrophin
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RARRES3 retinoic acid receptor responder (tazarotene induced) 3
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RSAD2 radical S-adenosyl methionine domain containing 2
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SSPN sarcospan
STC2 stanniocalcin 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THY1 Thy-1 cell surface antigen
TRDV3 T cell receptor delta variable 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
TYROBP TYRO protein tyrosine kinase binding protein
VSIG4 V-set and immunoglobulin domain containing 4
VTCN1 V-set domain containing T cell activation inhibitor 1
WT1 Wilms tumor 1
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZNF165 zinc finger protein 165
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ABHD2 abhydrolase domain containing 2
AFF1 AF4/FMR2 family, member 1
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARID4B AT rich interactive domain 4B (RBP1-like)
ASCL1 achaete-scute family bHLH transcription factor 1
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
BAG2 BCL2-associated athanogene 2
CALCA calcitonin-related polypeptide alpha
CCNA2 cyclin A2
CCNF cyclin F
CLDN18 claudin 18
CLTC clathrin, heavy chain (Hc)
CTSH cathepsin H
CXCL5 chemokine (C-X-C motif) ligand 5
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DICER1 dicer 1, ribonuclease type III
DST dystonin
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1
DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1
ECI2 enoyl-CoA delta isomerase 2
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FGF13 fibroblast growth factor 13
FRY furry homolog (Drosophila)
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
HMG20B high mobility group 20B
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGA6 integrin, alpha 6
JARID2 jumonji, AT rich interactive domain 2
KIAA0391 KIAA0391
KIF5B kinesin family member 5B
LAMC1 laminin, gamma 1 (formerly LAMB2)
LBR lamin B receptor
LONP2 lon peptidase 2, peroxisomal
LPP LIM domain containing preferred translocation partner in lipoma
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LTBP1 latent transforming growth factor beta binding protein 1
MED1 mediator complex subunit 1
MEGF9 multiple EGF-like-domains 9
MSX1 msh homeobox 1
MTCL1 microtubule crosslinking factor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
PIR pirin (iron-binding nuclear protein)
PLAC8 placenta-specific 8
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTCH1 patched 1
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RUFY3 RUN and FYVE domain containing 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SETD5 SET domain containing 5
SFN stratifin
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SORD sorbitol dehydrogenase
SPTSSA serine palmitoyltransferase, small subunit A
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
SVIL supervillin
TFF3 trefoil factor 3 (intestinal)
TLR4 toll-like receptor 4
TM9SF3 transmembrane 9 superfamily member 3
VCL vinculin