BRD-A02481876_Importazole_HT115_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

218 genes differentially expressed following the BRD-A02481876_Importazole_HT115_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
ANXA10 annexin A10
ARHGAP29 Rho GTPase activating protein 29
ARL4C ADP-ribosylation factor-like 4C
ARMCX1 armadillo repeat containing, X-linked 1
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE41 basic helix-loop-helix family, member e41
BMP2 bone morphogenetic protein 2
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
CADM1 cell adhesion molecule 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CD38 CD38 molecule
CD93 CD93 molecule
CDH13 cadherin 13
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFD complement factor D (adipsin)
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC2B C-type lectin domain family 2, member B
CPE carboxypeptidase E
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DPP4 dipeptidyl-peptidase 4
DPYSL3 dihydropyrimidinase-like 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR2 early growth response 2
EPAS1 endothelial PAS domain protein 1
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FSD1 fibronectin type III and SPRY domain containing 1
FZD1 frizzled class receptor 1
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GPNMB glycoprotein (transmembrane) nmb
GPR183 G protein-coupled receptor 183
GREM1 gremlin 1, DAN family BMP antagonist
GSTM3 glutathione S-transferase mu 3 (brain)
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
IGFBP5 insulin-like growth factor binding protein 5
IGHD immunoglobulin heavy constant delta
INHBA inhibin, beta A
IRF1 interferon regulatory factor 1
JCHAIN joining chain of multimeric IgA and IgM
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KDM5D lysine (K)-specific demethylase 5D
KLF9 Kruppel-like factor 9
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LPAR6 lysophosphatidic acid receptor 6
LY96 lymphocyte antigen 96
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MB myoglobin
MEIS2 Meis homeobox 2
MSLN mesothelin
MSMB microseminoprotein, beta-
MYBPC2 myosin binding protein C, fast type
MYOF myoferlin
NEB nebulin
NEFH neurofilament, heavy polypeptide
NID1 nidogen 1
NID2 nidogen 2 (osteonidogen)
NKX2-1 NK2 homeobox 1
NOX4 NADPH oxidase 4
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUP85 nucleoporin 85kDa
OLFML2A olfactomedin-like 2A
ORC1 origin recognition complex, subunit 1
PARP8 poly (ADP-ribose) polymerase family, member 8
PCP4 Purkinje cell protein 4
PDE4B phosphodiesterase 4B, cAMP-specific
PDLIM3 PDZ and LIM domain 3
PLAU plasminogen activator, urokinase
PLCL1 phospholipase C-like 1
PLK2 polo-like kinase 2
PLN phospholamban
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PPP1R13B protein phosphatase 1, regulatory subunit 13B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGCC regulator of cell cycle
RGS2 regulator of G-protein signaling 2
RGS5 regulator of G-protein signaling 5
RPS4Y1 ribosomal protein S4, Y-linked 1
RTN1 reticulon 1
RTN2 reticulon 2
S100P S100 calcium binding protein P
SCUBE2 signal peptide, CUB domain, EGF-like 2
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SFTPA2 surfactant protein A2
SGK1 serum/glucocorticoid regulated kinase 1
SH2B3 SH2B adaptor protein 3
SLC38A1 solute carrier family 38, member 1
SNAI2 snail family zinc finger 2
SOCS2 suppressor of cytokine signaling 2
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
ST6GALNAC5 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
STC1 stanniocalcin 1
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TBXA2R thromboxane A2 receptor
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
THBS2 thrombospondin 2
TIMP1 TIMP metallopeptidase inhibitor 1
TMEM110 transmembrane protein 110
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
ZFPM2 zinc finger protein, FOG family member 2
ZNF331 zinc finger protein 331

decreased expression

Symbol Name
ACSL5 acyl-CoA synthetase long-chain family member 5
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ASCC3 activating signal cointegrator 1 complex subunit 3
ASXL2 additional sex combs like transcriptional regulator 2
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
B3GNT1
BPHL biphenyl hydrolase-like (serine hydrolase)
BST2 bone marrow stromal cell antigen 2
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CD59 CD59 molecule, complement regulatory protein
CLCN3 chloride channel, voltage-sensitive 3
CPNE1 copine I
CRYL1 crystallin, lambda 1
CTR9 CTR9, Paf1/RNA polymerase II complex component
CXCL14 chemokine (C-X-C motif) ligand 14
DEFB1 defensin, beta 1
ECI2 enoyl-CoA delta isomerase 2
EHBP1 EH domain binding protein 1
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPHB2 EPH receptor B2
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FOLR1 folate receptor 1 (adult)
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HLTF helicase-like transcription factor
ITGA6 integrin, alpha 6
JARID2 jumonji, AT rich interactive domain 2
KCTD12 potassium channel tetramerization domain containing 12
KIDINS220 kinase D-interacting substrate, 220kDa
KRT10 keratin 10, type I
LBR lamin B receptor
LTBP1 latent transforming growth factor beta binding protein 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL1 muscleblind-like splicing regulator 1
MBP myelin basic protein
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MECOM MDS1 and EVI1 complex locus
MED6 mediator complex subunit 6
METRN meteorin, glial cell differentiation regulator
MSX1 msh homeobox 1
MYH10 myosin, heavy chain 10, non-muscle
MYO6 myosin VI
OPA1 optic atrophy 1 (autosomal dominant)
PARL presenilin associated, rhomboid-like
PCCA propionyl CoA carboxylase, alpha polypeptide
PDCD6 programmed cell death 6
PI3 peptidase inhibitor 3, skin-derived
PLK1 polo-like kinase 1
PRDX1 peroxiredoxin 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RCN2 reticulocalbin 2, EF-hand calcium binding domain
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPP1 selenoprotein P, plasma, 1
SMC1A structural maintenance of chromosomes 1A
SPINK5 serine peptidase inhibitor, Kazal type 5
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM2 transmembrane protein 2
TNC tenascin C
TSPAN3 tetraspanin 3
TUBB2B tubulin, beta 2B class IIb
XIST X inactive specific transcript (non-protein coding)
ZBTB38 zinc finger and BTB domain containing 38
ZC3H13 zinc finger CCCH-type containing 13
ZMYND8 zinc finger, MYND-type containing 8