BRD-A02481876_Importazole_HCT116_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

220 genes differentially expressed following the BRD-A02481876_Importazole_HCT116_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADM adrenomedullin
ADO 2-aminoethanethiol (cysteamine) dioxygenase
ANXA3 annexin A3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASPN asporin
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAMBI BMP and activin membrane-bound inhibitor
BASP1 brain abundant, membrane attached signal protein 1
BTG1 B-cell translocation gene 1, anti-proliferative
C3 complement component 3
CBS cystathionine-beta-synthase
CCL19 chemokine (C-C motif) ligand 19
CCNG2 cyclin G2
CD24 CD24 molecule
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
CLDN3 claudin 3
CLDN4 claudin 4
CLEC2B C-type lectin domain family 2, member B
COL15A1 collagen, type XV, alpha 1
CSTA cystatin A (stefin A)
CTGF connective tissue growth factor
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL8 chemokine (C-X-C motif) ligand 8
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DCN decorin
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO1 deiodinase, iodothyronine, type I
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DPT dermatopontin
DSP desmoplakin
DUSP1 dual specificity phosphatase 1
EGR2 early growth response 2
EHF ets homologous factor
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FAP fibroblast activation protein, alpha
FKBP11 FK506 binding protein 11, 19 kDa
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GAS1 growth arrest-specific 1
GATA3 GATA binding protein 3
GBP1 guanylate binding protein 1, interferon-inducible
GREM1 gremlin 1, DAN family BMP antagonist
HBB hemoglobin, beta
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HP haptoglobin
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
KLF4 Kruppel-like factor 4 (gut)
KRT14 keratin 14, type I
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
KRT6B keratin 6B, type II
KRT7 keratin 7, type II
LCN2 lipocalin 2
LGALS8 lectin, galactoside-binding, soluble, 8
LIMCH1 LIM and calponin homology domains 1
LTF lactotransferrin
LUM lumican
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MOCOS molybdenum cofactor sulfurase
NARS asparaginyl-tRNA synthetase
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NRN1 neuritin 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORM1 orosomucoid 1
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PERP PERP, TP53 apoptosis effector
PHGDH phosphoglycerate dehydrogenase
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXDC1 plexin domain containing 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
R3HDM4 R3H domain containing 4
REG1A regenerating islet-derived 1 alpha
RGS2 regulator of G-protein signaling 2
RPL31 ribosomal protein L31
S100A12 S100 calcium binding protein A12
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB2A2 secretoglobin, family 2A, member 2
SERINC1 serine incorporator 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO1B3 solute carrier organic anion transporter family, member 1B3
SNAI2 snail family zinc finger 2
SOD2 superoxide dismutase 2, mitochondrial
STK26 serine/threonine protein kinase 26
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TMEM45A transmembrane protein 45A
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TPD52 tumor protein D52
TYMP thymidine phosphorylase
UFM1 ubiquitin-fold modifier 1
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
VEGFA vascular endothelial growth factor A
VIM vimentin
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
ADCY9 adenylate cyclase 9
ADIRF adipogenesis regulatory factor
AKR1C1 aldo-keto reductase family 1, member C1
ALCAM activated leukocyte cell adhesion molecule
AMMECR1 Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
APP amyloid beta (A4) precursor protein
AQP1 aquaporin 1 (Colton blood group)
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARHGAP17 Rho GTPase activating protein 17
ASCC3 activating signal cointegrator 1 complex subunit 3
BEX1 brain expressed, X-linked 1
BPTF bromodomain PHD finger transcription factor
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CEP57 centrosomal protein 57kDa
COBLL1 cordon-bleu WH2 repeat protein-like 1
COG7 component of oligomeric golgi complex 7
DEFB1 defensin, beta 1
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
DPYSL2 dihydropyrimidinase-like 2
ECI2 enoyl-CoA delta isomerase 2
EIF5A eukaryotic translation initiation factor 5A
EPS8 epidermal growth factor receptor pathway substrate 8
FAT1 FAT atypical cadherin 1
FGFR3 fibroblast growth factor receptor 3
FLRT3 fibronectin leucine rich transmembrane protein 3
FOCAD focadhesin
FOXJ3 forkhead box J3
FRYL FRY-like
FZD5 frizzled class receptor 5
GALNT11 polypeptide N-acetylgalactosaminyltransferase 11
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HMGA2 high mobility group AT-hook 2
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LOC100505650 uncharacterized LOC100505650
LPCAT1 lysophosphatidylcholine acyltransferase 1
LPL lipoprotein lipase
LRRC16A leucine rich repeat containing 16A
MAGED1 melanoma antigen family D1
MAOB monoamine oxidase B
MAST2 microtubule associated serine/threonine kinase 2
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
MKL2 MKL/myocardin-like 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MYO10 myosin X
NDNF neuron-derived neurotrophic factor
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
NTS neurotensin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCOLCE2 procollagen C-endopeptidase enhancer 2
PGC progastricsin (pepsinogen C)
PHACTR2 phosphatase and actin regulator 2
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLIN2 perilipin 2
PPARG peroxisome proliferator-activated receptor gamma
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PRKCB protein kinase C, beta
PRSS2 protease, serine, 2 (trypsin 2)
QPRT quinolinate phosphoribosyltransferase
RGS10 regulator of G-protein signaling 10
RHOBTB3 Rho-related BTB domain containing 3
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SLC16A4 solute carrier family 16, member 4
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TGFBR3 transforming growth factor, beta receptor III
TIAM1 T-cell lymphoma invasion and metastasis 1
TMEM131 transmembrane protein 131
TMEM135 transmembrane protein 135
TRIM24 tripartite motif containing 24
TUBA1A tubulin, alpha 1a
UBE3C ubiquitin protein ligase E3C
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UNC13B unc-13 homolog B (C. elegans)
ZC3HAV1 zinc finger CCCH-type, antiviral 1