BRD-A02481876_Importazole_HCC515_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A02481876_Importazole_HCC515_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCNG2 cyclin G2
CD24 CD24 molecule
CD36 CD36 molecule (thrombospondin receptor)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLDN4 claudin 4
COL9A2 collagen, type IX, alpha 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DSP desmoplakin
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
FZD7 frizzled class receptor 7
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GNPDA1 glucosamine-6-phosphate deaminase 1
HACD1 3-hydroxyacyl-CoA dehydratase 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER3 immediate early response 3
IFRD1 interferon-related developmental regulator 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IRS2 insulin receptor substrate 2
JUNB jun B proto-oncogene
KLF11 Kruppel-like factor 11
KLF4 Kruppel-like factor 4 (gut)
LARP6 La ribonucleoprotein domain family, member 6
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
ODC1 ornithine decarboxylase 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RGS2 regulator of G-protein signaling 2
RNMT RNA (guanine-7-) methyltransferase
RORA RAR-related orphan receptor A
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SOCS2 suppressor of cytokine signaling 2
SOX4 SRY (sex determining region Y)-box 4
STAM signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
STC2 stanniocalcin 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TGIF1 TGFB-induced factor homeobox 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa
TUFT1 tuftelin 1
VEGFA vascular endothelial growth factor A
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
ANPEP alanyl (membrane) aminopeptidase
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
CALD1 caldesmon 1
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPF centromere protein F, 350/400kDa
CIT citron rho-interacting serine/threonine kinase
COL21A1 collagen, type XXI, alpha 1
CP ceruloplasmin (ferroxidase)
DOCK4 dedicator of cytokinesis 4
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
F2R coagulation factor II (thrombin) receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR3 fibroblast growth factor receptor 3
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GLUL glutamate-ammonia ligase
GRB14 growth factor receptor-bound protein 14
HELLS helicase, lymphoid-specific
HMGN3 high mobility group nucleosomal binding domain 3
IFI44 interferon-induced protein 44
IFI44L interferon-induced protein 44-like
IGLL1 immunoglobulin lambda-like polypeptide 1
KIAA0101 KIAA0101
LTBP2 latent transforming growth factor beta binding protein 2
MECOM MDS1 and EVI1 complex locus
MTDH metadherin
NFIB nuclear factor I/B
NR2F2 nuclear receptor subfamily 2, group F, member 2
PEBP1 phosphatidylethanolamine binding protein 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RDX radixin
SEPW1 selenoprotein W, 1
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
UBR5 ubiquitin protein ligase E3 component n-recognin 5
VWF von Willebrand factor
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)
ZMIZ1 zinc finger, MIZ-type containing 1