BRD-A02481876_Importazole_HCC515_24.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

231 genes differentially expressed following the BRD-A02481876_Importazole_HCC515_24.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
APOD apolipoprotein D
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ARMCX2 armadillo repeat containing, X-linked 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C3ORF14 chromosome 3 open reading frame 14
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTSL cathepsin L
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
FEM1C fem-1 homolog c (C. elegans)
FOSL1 FOS-like antigen 1
FOXO4 forkhead box O4
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45A growth arrest and DNA-damage-inducible, alpha
GNPDA1 glucosamine-6-phosphate deaminase 1
GPNMB glycoprotein (transmembrane) nmb
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
ICAM1 intercellular adhesion molecule 1
IDS iduronate 2-sulfatase
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
KLHL21 kelch-like family member 21
KLHL24 kelch-like family member 24
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA3 melanoma antigen family A3
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCOLN1 mucolipin 1
MEPCE methylphosphate capping enzyme
NCF2 neutrophil cytosolic factor 2
NINJ1 ninjurin 1
NOV nephroblastoma overexpressed
NPC1 Niemann-Pick disease, type C1
NRBF2 nuclear receptor binding factor 2
NUPR1 nuclear protein, transcriptional regulator, 1
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLEKHO2 pleckstrin homology domain containing, family O member 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RABAC1 Rab acceptor 1 (prenylated)
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RNF19B ring finger protein 19B
RNMT RNA (guanine-7-) methyltransferase
RRAGD Ras-related GTP binding D
SDCBP syndecan binding protein (syntenin)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERTAD2 SERTA domain containing 2
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMIM7 small integral membrane protein 7
STC2 stanniocalcin 2
STK26 serine/threonine protein kinase 26
STX3 syntaxin 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS4 thrombospondin 4
TICAM1 toll-like receptor adaptor molecule 1
TP53 tumor protein p53
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45
ZNF222 zinc finger protein 222

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
ADGRG6 adhesion G protein-coupled receptor G6
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANOS1 anosmin 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASCC3 activating signal cointegrator 1 complex subunit 3
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BIRC5 baculoviral IAP repeat containing 5
BZW2 basic leucine zipper and W2 domains 2
C2CD5 C2 calcium-dependent domain containing 5
C3 complement component 3
C5 complement component 5
CALD1 caldesmon 1
CALR calreticulin
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CCNA2 cyclin A2
CCND3 cyclin D3
CD44 CD44 molecule (Indian blood group)
CDC45 cell division cycle 45
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CFH complement factor H
CFI complement factor I
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
CP ceruloplasmin (ferroxidase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CSRP2 cysteine and glycine-rich protein 2
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EHBP1 EH domain binding protein 1
ENAH enabled homolog (Drosophila)
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FANCI Fanconi anemia, complementation group I
FAT1 FAT atypical cadherin 1
FGFR3 fibroblast growth factor receptor 3
FJX1 four jointed box 1 (Drosophila)
FN1 fibronectin 1
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
HAT1 histone acetyltransferase 1
HEG1 heart development protein with EGF-like domains 1
HES1 hes family bHLH transcription factor 1
IFRD2 interferon-related developmental regulator 2
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITGA6 integrin, alpha 6
ITGAV integrin, alpha V
KIAA0101 KIAA0101
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIG1 ligase I, DNA, ATP-dependent
LIMA1 LIM domain and actin binding 1
LIMCH1 LIM and calponin homology domains 1
LMNB1 lamin B1
LOXL2 lysyl oxidase-like 2
LY6E lymphocyte antigen 6 complex, locus E
LYPD1 LY6/PLAUR domain containing 1
LYZ lysozyme
MACF1 microtubule-actin crosslinking factor 1
MAN1A2 mannosidase, alpha, class 1A, member 2
MBNL1 muscleblind-like splicing regulator 1
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYCBP MYC binding protein
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase
MYH10 myosin, heavy chain 10, non-muscle
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NME1 NME/NM23 nucleoside diphosphate kinase 1
NME4 NME/NM23 nucleoside diphosphate kinase 4
NNMT nicotinamide N-methyltransferase
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
NUP85 nucleoporin 85kDa
PBX1 pre-B-cell leukemia homeobox 1
PCCB propionyl CoA carboxylase, beta polypeptide
PCNA proliferating cell nuclear antigen
PECR peroxisomal trans-2-enoyl-CoA reductase
PHACTR2 phosphatase and actin regulator 2
PHKB phosphorylase kinase, beta
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PON3 paraoxonase 3
PPA1 pyrophosphatase (inorganic) 1
PRKCA protein kinase C, alpha
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PROM1 prominin 1
PRSS23 protease, serine, 23
RANBP1 RAN binding protein 1
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RRM2 ribonucleotide reductase M2
SCARB1 scavenger receptor class B, member 1
SCP2 sterol carrier protein 2
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMAD6 SMAD family member 6
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMC4 structural maintenance of chromosomes 4
SPDEF SAM pointed domain containing ETS transcription factor
STOM stomatin
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGM2 transglutaminase 2
TK1 thymidine kinase 1, soluble
TMEM2 transmembrane protein 2
TMEM47 transmembrane protein 47
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM24 tripartite motif containing 24
TRIP13 thyroid hormone receptor interactor 13
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TYMS thymidylate synthetase
VAV3 vav 3 guanine nucleotide exchange factor
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
ZWINT ZW10 interacting kinetochore protein