BRD-A02481876_Importazole_HA1E_24.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

443 genes differentially expressed following the BRD-A02481876_Importazole_HA1E_24.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM28 ADAM metallopeptidase domain 28
ADAM8 ADAM metallopeptidase domain 8
ADGRE5 adhesion G protein-coupled receptor E5
ADIRF adipogenesis regulatory factor
AIM2 absent in melanoma 2
ALAS1 5'-aminolevulinate synthase 1
ALOX5 arachidonate 5-lipoxygenase
AMPD3 adenosine monophosphate deaminase 3
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
C19ORF66 chromosome 19 open reading frame 66
C1ORF106 chromosome 1 open reading frame 106
C1ORF116 chromosome 1 open reading frame 116
CBX7 chromobox homolog 7
CCDC93 coiled-coil domain containing 93
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDC34 cell division cycle 34
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHPT1 choline phosphotransferase 1
CIDEB cell death-inducing DFFA-like effector b
CLEC2B C-type lectin domain family 2, member B
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2
CSTB cystatin B (stefin B)
CTSL cathepsin L
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL13 chemokine (C-X-C motif) ligand 13
DDIT3 DNA-damage-inducible transcript 3
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP3 dual specificity phosphatase 3
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EML3 echinoderm microtubule associated protein like 3
ETV5 ets variant 5
FAM134A family with sequence similarity 134, member A
FEM1B fem-1 homolog b (C. elegans)
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOXO4 forkhead box O4
FRAT1 frequently rearranged in advanced T-cell lymphomas 1
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
GAL galanin/GMAP prepropeptide
GDF15 growth differentiation factor 15
GNPDA1 glucosamine-6-phosphate deaminase 1
GPM6B glycoprotein M6B
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HIST3H2A histone cluster 3, H2a
HLA-F major histocompatibility complex, class I, F
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1
IER2 immediate early response 2
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IFITM1 interferon induced transmembrane protein 1
IGFBP6 insulin-like growth factor binding protein 6
IGHM immunoglobulin heavy constant mu
IL1RN interleukin 1 receptor antagonist
IL24 interleukin 24
INPP1 inositol polyphosphate-1-phosphatase
IRAK1 interleukin-1 receptor-associated kinase 1
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ISG20 interferon stimulated exonuclease gene 20kDa
JADE2 jade family PHD finger 2
JOSD1 Josephin domain containing 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDSR 3-ketodihydrosphingosine reductase
KLF11 Kruppel-like factor 11
KLHL24 kelch-like family member 24
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KYNU kynureninase
LAMP3 lysosomal-associated membrane protein 3
LPAR2 lysophosphatidic acid receptor 2
LY6E lymphocyte antigen 6 complex, locus E
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAP2K3 mitogen-activated protein kinase kinase 3
MCOLN1 mucolipin 1
MKNK2 MAP kinase interacting serine/threonine kinase 2
MME membrane metallo-endopeptidase
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
NPC1 Niemann-Pick disease, type C1
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa
OASL 2'-5'-oligoadenylate synthetase-like
P2RY13 purinergic receptor P2Y, G-protein coupled, 13
PARP12 poly (ADP-ribose) polymerase family, member 12
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PHGDH phosphoglycerate dehydrogenase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PIP prolactin-induced protein
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1
PLSCR1 phospholipid scramblase 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2C phosphatidic acid phosphatase type 2C
PPL periplakin
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
R3HDM4 R3H domain containing 4
RAD9A RAD9 homolog A (S. pombe)
RALGDS ral guanine nucleotide dissociation stimulator
RAP1GAP2 RAP1 GTPase activating protein 2
RBM47 RNA binding motif protein 47
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RHOF ras homolog family member F (in filopodia)
RNF103 ring finger protein 103
RRAGD Ras-related GTP binding D
RSAD2 radical S-adenosyl methionine domain containing 2
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SESN1 sestrin 1
SGK1 serum/glucocorticoid regulated kinase 1
SIRT1 sirtuin 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC43A3 solute carrier family 43, member 3
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SMIM7 small integral membrane protein 7
SOD2 superoxide dismutase 2, mitochondrial
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SQSTM1 sequestosome 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STK26 serine/threonine protein kinase 26
STX3 syntaxin 3
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TERF2IP telomeric repeat binding factor 2, interacting protein
TFE3 transcription factor binding to IGHM enhancer 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRAF4 TNF receptor-associated factor 4
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TYMP thymidine phosphorylase
UPP1 uridine phosphorylase 1
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDR45 WD repeat domain 45
WIF1 WNT inhibitory factor 1

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACAT2 acetyl-CoA acetyltransferase 2
ACTA2 actin, alpha 2, smooth muscle, aorta
ACTN1 actinin, alpha 1
ACTR3 ARP3 actin-related protein 3 homolog (yeast)
ADAM10 ADAM metallopeptidase domain 10
ADAM12 ADAM metallopeptidase domain 12
ADAM19 ADAM metallopeptidase domain 19
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADD3 adducin 3 (gamma)
AK4 adenylate kinase 4
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ANO10 anoctamin 10
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ARL3 ADP-ribosylation factor-like 3
ASCC3 activating signal cointegrator 1 complex subunit 3
ATF6 activating transcription factor 6
ATG5 autophagy related 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4
ATXN1 ataxin 1
AUTS2 autism susceptibility candidate 2
BACE2 beta-site APP-cleaving enzyme 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BDNF brain-derived neurotrophic factor
BICC1 BicC family RNA binding protein 1
BMP1 bone morphogenetic protein 1
BNC2 basonuclin 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C11ORF49 chromosome 11 open reading frame 49
C1QTNF3 C1q and tumor necrosis factor related protein 3
CA9 carbonic anhydrase IX
CALD1 caldesmon 1
CALU calumenin
CAP2 CAP, adenylate cyclase-associated protein, 2 (yeast)
CASP6 caspase 6, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL2 chemokine (C-C motif) ligand 2
CD200 CD200 molecule
CD24 CD24 molecule
CD59 CD59 molecule, complement regulatory protein
CDC42 cell division cycle 42
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK19 cyclin-dependent kinase 19
CENPF centromere protein F, 350/400kDa
CETN2 centrin, EF-hand protein, 2
CFI complement factor I
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHMP6 charged multivesicular body protein 6
CKAP4 cytoskeleton-associated protein 4
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
COMMD10 COMM domain containing 10
CSRP2 cysteine and glycine-rich protein 2
CTSC cathepsin C
CYCS cytochrome c, somatic
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DCAF6 DDB1 and CUL4 associated factor 6
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DEPTOR DEP domain containing MTOR-interacting protein
DERA deoxyribose-phosphate aldolase (putative)
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLC1 DLC1 Rho GTPase activating protein
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DST dystonin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
EGLN3 egl-9 family hypoxia-inducible factor 3
EHBP1 EH domain binding protein 1
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L2 erythrocyte membrane protein band 4.1-like 2
EPHB2 EPH receptor B2
ERAP2 endoplasmic reticulum aminopeptidase 2
EVL Enah/Vasp-like
F2R coagulation factor II (thrombin) receptor
FABP1 fatty acid binding protein 1, liver
FABP7 fatty acid binding protein 7, brain
FAM114A1 family with sequence similarity 114, member A1
FAM134B family with sequence similarity 134, member B
FAM171A1 family with sequence similarity 171, member A1
FAM172A family with sequence similarity 172, member A
FBN1 fibrillin 1
FILIP1L filamin A interacting protein 1-like
FKBP14 FK506 binding protein 14, 22 kDa
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FOCAD focadhesin
FSTL1 follistatin-like 1
FTO fat mass and obesity associated
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GBE1 glucan (1,4-alpha-), branching enzyme 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
GPX2 glutathione peroxidase 2
GPX3 glutathione peroxidase 3
GRB10 growth factor receptor-bound protein 10
HADH hydroxyacyl-CoA dehydrogenase
HEG1 heart development protein with EGF-like domains 1
HOMER2 homer scaffolding protein 2
HOXA10 homeobox A10
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSDL2 hydroxysteroid dehydrogenase like 2
HSPG2 heparan sulfate proteoglycan 2
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGF1R insulin-like growth factor 1 receptor
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL6ST interleukin 6 signal transducer
ITGAV integrin, alpha V
ITM2C integral membrane protein 2C
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIF20A kinesin family member 20A
LAMA4 laminin, alpha 4
LAMB1 laminin, beta 1
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LIMA1 LIM domain and actin binding 1
LIPA lipase A, lysosomal acid, cholesterol esterase
LOC100505650 uncharacterized LOC100505650
LOX lysyl oxidase
LOXL1 lysyl oxidase-like 1
LOXL2 lysyl oxidase-like 2
LRBA LPS-responsive vesicle trafficking, beach and anchor containing
LRRC16A leucine rich repeat containing 16A
LRRC17 leucine rich repeat containing 17
LTBP2 latent transforming growth factor beta binding protein 2
LUM lumican
LYPD1 LY6/PLAUR domain containing 1
LYRM4 LYR motif containing 4
MAGED1 melanoma antigen family D1
MARCKS myristoylated alanine-rich protein kinase C substrate
MATN2 matrilin 2
MBNL1 muscleblind-like splicing regulator 1
MCAM melanoma cell adhesion molecule
MDFIC MyoD family inhibitor domain containing
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MECOM MDS1 and EVI1 complex locus
MEIS2 Meis homeobox 2
MGP matrix Gla protein
MID1 midline 1
MKL2 MKL/myocardin-like 2
MMP10 matrix metallopeptidase 10
MNAT1 MNAT CDK-activating kinase assembly factor 1
MOK MOK protein kinase
MSRA methionine sulfoxide reductase A
MYCBP MYC binding protein
MYH10 myosin, heavy chain 10, non-muscle
MYLK myosin light chain kinase
MYO10 myosin X
MYOF myoferlin
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NLGN1 neuroligin 1
NNMT nicotinamide N-methyltransferase
NPR3 natriuretic peptide receptor 3
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRCAM neuronal cell adhesion molecule
NREP neuronal regeneration related protein
NRG1 neuregulin 1
NRP1 neuropilin 1
NXN nucleoredoxin
OLFM4 olfactomedin 4
OXCT1 3-oxoacid CoA transferase 1
P3H2 prolyl 3-hydroxylase 2
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I
PALLD palladin, cytoskeletal associated protein
PAM peptidylglycine alpha-amidating monooxygenase
PAX8 paired box 8
PBX1 pre-B-cell leukemia homeobox 1
PCCB propionyl CoA carboxylase, beta polypeptide
PDGFC platelet derived growth factor C
PDIA4 protein disulfide isomerase family A, member 4
PDLIM5 PDZ and LIM domain 5
PDZK1 PDZ domain containing 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PEG10 paternally expressed 10
PGK1 phosphoglycerate kinase 1
PGM1 phosphoglucomutase 1
PHACTR2 phosphatase and actin regulator 2
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAT plasminogen activator, tissue
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PLEKHA5 pleckstrin homology domain containing, family A member 5
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PLXNA2 plexin A2
PON2 paraoxonase 2
POSTN periostin, osteoblast specific factor
PRKCA protein kinase C, alpha
PRSS23 protease, serine, 23
PTK2 protein tyrosine kinase 2
PTPRG protein tyrosine phosphatase, receptor type, G
RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2
RBM3 RNA binding motif (RNP1, RRM) protein 3
RBP1 retinol binding protein 1, cellular
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RRBP1 ribosome binding protein 1
SCP2 sterol carrier protein 2
SDC2 syndecan 2
SEC23A Sec23 homolog A (S. cerevisiae)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SELE selectin E
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPT11 septin 11
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP4 secreted frizzled-related protein 4
SH3BGRL SH3 domain binding glutamate-rich protein like
SLC16A4 solute carrier family 16, member 4
SLC17A3 solute carrier family 17 (organic anion transporter), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
SMYD3 SET and MYND domain containing 3
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SOX17 SRY (sex determining region Y)-box 17
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
STXBP6 syntaxin binding protein 6 (amisyn)
SULF1 sulfatase 1
TCF4 transcription factor 4
TGFB2 transforming growth factor, beta 2
TGFBI transforming growth factor, beta-induced, 68kDa
TGM2 transglutaminase 2
THBS1 thrombospondin 1
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMCC1 transmembrane and coiled-coil domain family 1
TMEM135 transmembrane protein 135
TMEM14A transmembrane protein 14A
TMEM47 transmembrane protein 47
TNC tenascin C
TOX thymocyte selection-associated high mobility group box
TPM1 tropomyosin 1 (alpha)
TPM4 tropomyosin 4
TPMT thiopurine S-methyltransferase
TSPAN13 tetraspanin 13
TTC28 tetratricopeptide repeat domain 28
TUBB tubulin, beta class I
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
USO1 USO1 vesicle transport factor
VCAN versican
VWF von Willebrand factor
WFDC2 WAP four-disulfide core domain 2
WNT5A wingless-type MMTV integration site family, member 5A
WWTR1 WW domain containing transcription regulator 1
ZBTB20 zinc finger and BTB domain containing 20
ZBTB38 zinc finger and BTB domain containing 38