BRD-A02481876_Importazole_CORL23_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

160 genes differentially expressed following the BRD-A02481876_Importazole_CORL23_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD3 abhydrolase domain containing 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADCK3 aarF domain containing kinase 3
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGR2 anterior gradient 2
ANKRD10 ankyrin repeat domain 10
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
CCL19 chemokine (C-C motif) ligand 19
CCR7 chemokine (C-C motif) receptor 7
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CFB complement factor B
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC2B C-type lectin domain family 2, member B
COL14A1 collagen, type XIV, alpha 1
CPVL carboxypeptidase, vitellogenic-like
CTH cystathionine gamma-lyase
CXCL9 chemokine (C-X-C motif) ligand 9
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DMTF1 cyclin D binding myb-like transcription factor 1
DPH2 DPH2 homolog (S. cerevisiae)
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3
DSP desmoplakin
DUSP14 dual specificity phosphatase 14
DUSP2 dual specificity phosphatase 2
EGR2 early growth response 2
FHL1 four and a half LIM domains 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GARS glycyl-tRNA synthetase
GATA2 GATA binding protein 2
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLA galactosidase, alpha
GNL2 guanine nucleotide binding protein-like 2 (nucleolar)
GPX3 glutathione peroxidase 3
HIST3H2A histone cluster 3, H2a
HSPB8 heat shock 22kDa protein 8
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
ITM2A integral membrane protein 2A
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KCTD5 potassium channel tetramerization domain containing 5
KLF4 Kruppel-like factor 4 (gut)
KLHL21 kelch-like family member 21
KRT16 keratin 16, type I
KRT17 keratin 17, type I
LONP1 lon peptidase 1, mitochondrial
LTF lactotransferrin
MFAP5 microfibrillar associated protein 5
MMP12 matrix metallopeptidase 12
MYO5C myosin VC
NDRG1 N-myc downstream regulated 1
NKX3-1 NK3 homeobox 1
OXCT1 3-oxoacid CoA transferase 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
RHOB ras homolog family member B
RNMT RNA (guanine-7-) methyltransferase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCAND1 SCAN domain containing 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SFN stratifin
SIK1 salt-inducible kinase 1
TARS threonyl-tRNA synthetase
TMEM45A transmembrane protein 45A
TNC tenascin C
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRBC1 T cell receptor beta constant 1
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TUFT1 tuftelin 1
UFM1 ubiquitin-fold modifier 1
UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein (yeast)
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ACSL3 acyl-CoA synthetase long-chain family member 3
ADAM10 ADAM metallopeptidase domain 10
AKR1C2 aldo-keto reductase family 1, member C2
AMIGO2 adhesion molecule with Ig-like domain 2
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
APP amyloid beta (A4) precursor protein
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARID4B AT rich interactive domain 4B (RBP1-like)
B3GNT1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CCNI cyclin I
CD59 CD59 molecule, complement regulatory protein
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CNOT4 CCR4-NOT transcription complex, subunit 4
DACH1 dachshund family transcription factor 1
DENND1B DENN/MADD domain containing 1B
DKK3 dickkopf WNT signaling pathway inhibitor 3
ESR1 estrogen receptor 1
FABP7 fatty acid binding protein 7, brain
FBN2 fibrillin 2
FN1 fibronectin 1
FOXG1 forkhead box G1
FRYL FRY-like
FXYD6 FXYD domain containing ion transport regulator 6
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GALNT7 polypeptide N-acetylgalactosaminyltransferase 7
GNAS GNAS complex locus
GRIA2 glutamate receptor, ionotropic, AMPA 2
HILPDA hypoxia inducible lipid droplet-associated
HIST1H4C histone cluster 1, H4c
HMGA2 high mobility group AT-hook 2
HSPA8 heat shock 70kDa protein 8
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
LDB2 LIM domain binding 2
LRP2 low density lipoprotein receptor-related protein 2
MBNL2 muscleblind-like splicing regulator 2
MDK midkine (neurite growth-promoting factor 2)
MEGF9 multiple EGF-like-domains 9
MME membrane metallo-endopeptidase
MRPS16 mitochondrial ribosomal protein S16
MRPS28 mitochondrial ribosomal protein S28
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NREP neuronal regeneration related protein
NRIP1 nuclear receptor interacting protein 1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NTS neurotensin
OLFML2A olfactomedin-like 2A
PBX1 pre-B-cell leukemia homeobox 1
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB4 phospholipase C, beta 4
PLK2 polo-like kinase 2
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PSRC1 proline/serine-rich coiled-coil 1
PTEN phosphatase and tensin homolog
PTX3 pentraxin 3, long
RAB38 RAB38, member RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RHOBTB1 Rho-related BTB domain containing 1
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SOX11 SRY (sex determining region Y)-box 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TMPO thymopoietin
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)