BRD-A02481876_Importazole_AGS_6.0_h_60.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

243 genes differentially expressed following the BRD-A02481876_Importazole_AGS_6.0_h_60.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
AKR7A3 aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOB aldolase B, fructose-bisphosphate
ANO1 anoctamin 1, calcium activated chloride channel
ANXA10 annexin A10
AREG amphiregulin
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2A3 ATPase, Ca++ transporting, ubiquitous
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BHLHE40 basic helix-loop-helix family, member e40
BRD2 bromodomain containing 2
BTG1 B-cell translocation gene 1, anti-proliferative
C5AR1 complement component 5a receptor 1
CA2 carbonic anhydrase II
CCNG2 cyclin G2
CD1E CD1e molecule
CD24 CD24 molecule
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CD9 CD9 molecule
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CES2 carboxylesterase 2
CFP complement factor properdin
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLC Charcot-Leyden crystal galectin
CLDND1 claudin domain containing 1
CLEC10A C-type lectin domain family 10, member A
CLEC2B C-type lectin domain family 2, member B
COL11A1 collagen, type XI, alpha 1
COL9A3 collagen, type IX, alpha 3
CRIP1 cysteine-rich protein 1 (intestinal)
CSTA cystatin A (stefin A)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DDIT4 DNA-damage-inducible transcript 4
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EFHD1 EF-hand domain family, member D1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FAM171A1 family with sequence similarity 171, member A1
FHL1 four and a half LIM domains 1
FMO3 flavin containing monooxygenase 3
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GEM GTP binding protein overexpressed in skeletal muscle
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
H1F0 H1 histone family, member 0
HBB hemoglobin, beta
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
JUND jun D proto-oncogene
KCTD12 potassium channel tetramerization domain containing 12
KCTD5 potassium channel tetramerization domain containing 5
KLF6 Kruppel-like factor 6
KLHL21 kelch-like family member 21
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6B keratin 6B, type II
LDB3 LIM domain binding 3
LDLR low density lipoprotein receptor
LGALS4 lectin, galactoside-binding, soluble, 4
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MFAP5 microfibrillar associated protein 5
MTSS1 metastasis suppressor 1
MXI1 MAX interactor 1, dimerization protein
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
OLFM4 olfactomedin 4
PALLD palladin, cytoskeletal associated protein
PAN2 PAN2 poly(A) specific ribonuclease subunit
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PLAU plasminogen activator, urokinase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PMP22 peripheral myelin protein 22
PRNP prion protein
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RAB31 RAB31, member RAS oncogene family
RALGDS ral guanine nucleotide dissociation stimulator
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RIOK3 RIO kinase 3
S100A2 S100 calcium binding protein A2
SCG5 secretogranin V
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A2 secretoglobin, family 2A, member 2
SCN3A sodium channel, voltage gated, type III alpha subunit
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFN stratifin
SGK1 serum/glucocorticoid regulated kinase 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC38A1 solute carrier family 38, member 1
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNAI2 snail family zinc finger 2
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SRC SRC proto-oncogene, non-receptor tyrosine kinase
ST18 suppression of tumorigenicity 18, zinc finger
STC2 stanniocalcin 2
SULF1 sulfatase 1
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TFF1 trefoil factor 1
THBS1 thrombospondin 1
TMEFF1 transmembrane protein with EGF-like and two follistatin-like domains 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM259 transmembrane protein 259
TPP1 tripeptidyl peptidase I
TRIB1 tribbles pseudokinase 1
TSPAN1 tetraspanin 1
TUBA1A tubulin, alpha 1a
TUBB2A tubulin, beta 2A class IIa
TXNIP thioredoxin interacting protein
UPP1 uridine phosphorylase 1
VCAN versican
VEGFA vascular endothelial growth factor A
VIM vimentin
VNN1 vanin 1
WDR45 WD repeat domain 45
ZBTB18 zinc finger and BTB domain containing 18
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACACA acetyl-CoA carboxylase alpha
AFF1 AF4/FMR2 family, member 1
AKAP7 A kinase (PRKA) anchor protein 7
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALG8 ALG8, alpha-1,3-glucosyltransferase
AMD1 adenosylmethionine decarboxylase 1
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ASCC3 activating signal cointegrator 1 complex subunit 3
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
AURKA aurora kinase A
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BLVRA biliverdin reductase A
BMPR1A bone morphogenetic protein receptor, type IA
C8ORF4 chromosome 8 open reading frame 4
CCNA2 cyclin A2
CCND2 cyclin D2
CCNF cyclin F
CFI complement factor I
CHL1 cell adhesion molecule L1-like
CLNS1A chloride channel, nucleotide-sensitive, 1A
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DIRAS3 DIRAS family, GTP-binding RAS-like 3
DLD dihydrolipoamide dehydrogenase
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENDOD1 endonuclease domain containing 1
FGF13 fibroblast growth factor 13
FLRT3 fibronectin leucine rich transmembrane protein 3
FNDC3B fibronectin type III domain containing 3B
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10
GRWD1 glutamate-rich WD repeat containing 1
HDHD1 haloacid dehalogenase-like hydrolase domain containing 1
HES1 hes family bHLH transcription factor 1
HLTF helicase-like transcription factor
HOPX HOP homeobox
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
KIF20A kinesin family member 20A
LAMC1 laminin, gamma 1 (formerly LAMB2)
LAPTM4B lysosomal protein transmembrane 4 beta
LMO2 LIM domain only 2 (rhombotin-like 1)
LPCAT1 lysophosphatidylcholine acyltransferase 1
LRRC16A leucine rich repeat containing 16A
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MBNL1 muscleblind-like splicing regulator 1
MBOAT7 membrane bound O-acyltransferase domain containing 7
MFSD10 major facilitator superfamily domain containing 10
MLEC malectin
MYO10 myosin X
NCALD neurocalcin delta
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME4 NME/NM23 nucleoside diphosphate kinase 4
NRCAM neuronal cell adhesion molecule
ORC5 origin recognition complex, subunit 5
PHACTR2 phosphatase and actin regulator 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLK1 polo-like kinase 1
PON2 paraoxonase 2
PPARG peroxisome proliferator-activated receptor gamma
PRSS23 protease, serine, 23
PTDSS1 phosphatidylserine synthase 1
QPRT quinolinate phosphoribosyltransferase
R3HDM1 R3H domain containing 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBPMS RNA binding protein with multiple splicing
RREB1 ras responsive element binding protein 1
RRP1B ribosomal RNA processing 1B
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A11 S100 calcium binding protein A11
SAMM50 SAMM50 sorting and assembly machinery component
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC35F2 solute carrier family 35, member F2
SLPI secretory leukocyte peptidase inhibitor
TFRC transferrin receptor
TIAM1 T-cell lymphoma invasion and metastasis 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK1 tousled-like kinase 1
TMEM100 transmembrane protein 100
TMEM135 transmembrane protein 135
TMEM164 transmembrane protein 164
TNIK TRAF2 and NCK interacting kinase
TRIM14 tripartite motif containing 14
TRIM24 tripartite motif containing 24
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UNC13B unc-13 homolog B (C. elegans)
WDR12 WD repeat domain 12
WFS1 Wolfram syndrome 1 (wolframin)
WIF1 WNT inhibitory factor 1
WNT5A wingless-type MMTV integration site family, member 5A
XPO7 exportin 7
YLPM1 YLP motif containing 1
ZMYM2 zinc finger, MYM-type 2