BRD-A02333338_C3393M50_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

332 genes differentially expressed following the BRD-A02333338_C3393M50_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ACPP acid phosphatase, prostate
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
AEBP1 AE binding protein 1
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANOS1 anosmin 1
ANXA1 annexin A1
ANXA4 annexin A4
ARL4C ADP-ribosylation factor-like 4C
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL20 chemokine (C-C motif) ligand 20
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CFB complement factor B
CLC Charcot-Leyden crystal galectin
CLIC4 chloride intracellular channel 4
CLIC5 chloride intracellular channel 5
CNN3 calponin 3, acidic
COL11A1 collagen, type XI, alpha 1
COL1A2 collagen, type I, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CTGF connective tissue growth factor
CTSZ cathepsin Z
CXADR coxsackie virus and adenovirus receptor
CYB5A cytochrome b5 type A (microsomal)
CYBRD1 cytochrome b reductase 1
DCT dopachrome tautomerase
DEFA4 defensin, alpha 4, corticostatin
DHCR24 24-dehydrocholesterol reductase
DKK2 dickkopf WNT signaling pathway inhibitor 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DOK5 docking protein 5
DPYSL3 dihydropyrimidinase-like 3
DST dystonin
EMP1 epithelial membrane protein 1
ENO1 enolase 1, (alpha)
F3 coagulation factor III (thromboplastin, tissue factor)
FAM198B family with sequence similarity 198, member B
FHL1 four and a half LIM domains 1
FLT1 fms-related tyrosine kinase 1
FN1 fibronectin 1
GJA1 gap junction protein, alpha 1, 43kDa
GLO1 glyoxalase I
GPM6A glycoprotein M6A
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
IFITM3 interferon induced transmembrane protein 3
IRF6 interferon regulatory factor 6
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA6 integrin, alpha 6
LAPTM5 lysosomal protein transmembrane 5
LEPR leptin receptor
MAOA monoamine oxidase A
MDFIC MyoD family inhibitor domain containing
MEIS2 Meis homeobox 2
MSN moesin
MT1M metallothionein 1M
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYOF myoferlin
NID1 nidogen 1
NMU neuromedin U
NR4A3 nuclear receptor subfamily 4, group A, member 3
OLFM4 olfactomedin 4
PCSK6 proprotein convertase subtilisin/kexin type 6
PEA15 phosphoprotein enriched in astrocytes 15
PGK1 phosphoglycerate kinase 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRTN3 proteinase 3
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PYCARD PYD and CARD domain containing
QPCT glutaminyl-peptide cyclotransferase
RAB31 RAB31, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEPT10 septin 10
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SH3BGR SH3 domain binding glutamate-rich protein
SORD sorbitol dehydrogenase
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPON1 spondin 1, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCF4 transcription factor 4
TFPI2 tissue factor pathway inhibitor 2
TGFBI transforming growth factor, beta-induced, 68kDa
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM230 transmembrane protein 230
TMEM45A transmembrane protein 45A
TMEM47 transmembrane protein 47
TMSB15A thymosin beta 15a
TPD52 tumor protein D52
TRIM2 tripartite motif containing 2
TSPAN31 tetraspanin 31
TYRP1 tyrosinase-related protein 1
UNC13B unc-13 homolog B (C. elegans)
VAMP3 vesicle-associated membrane protein 3

decreased expression

Symbol Name
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACBD3 acyl-CoA binding domain containing 3
ADNP activity-dependent neuroprotector homeobox
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AFF1 AF4/FMR2 family, member 1
AMD1 adenosylmethionine decarboxylase 1
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARHGAP12 Rho GTPase activating protein 12
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ARID4B AT rich interactive domain 4B (RBP1-like)
ARL4A ADP-ribosylation factor-like 4A
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
AURKA aurora kinase A
BAMBI BMP and activin membrane-bound inhibitor
BCL7B B-cell CLL/lymphoma 7B
BLCAP bladder cancer associated protein
BLM Bloom syndrome, RecQ helicase-like
BRPF1 bromodomain and PHD finger containing, 1
CA12 carbonic anhydrase XII
CANT1 calcium activated nucleotidase 1
CAPN6 calpain 6
CCL5 chemokine (C-C motif) ligand 5
CCNA2 cyclin A2
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CEP350 centrosomal protein 350kDa
CEP76 centrosomal protein 76kDa
CGRRF1 cell growth regulator with ring finger domain 1
CHSY1 chondroitin sulfate synthase 1
CKS2 CDC28 protein kinase regulatory subunit 2
CLIC3 chloride intracellular channel 3
CLK4 CDC-like kinase 4
CNOT4 CCR4-NOT transcription complex, subunit 4
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)
COIL coilin
DBF4 DBF4 zinc finger
DCLRE1C DNA cross-link repair 1C
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DICER1 dicer 1, ribonuclease type III
DLK1 delta-like 1 homolog (Drosophila)
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
DPF2 D4, zinc and double PHD fingers family 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
EDRF1 erythroid differentiation regulatory factor 1
EED embryonic ectoderm development
EHD1 EH-domain containing 1
EIF5 eukaryotic translation initiation factor 5
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EXOSC4 exosome component 4
FAM13B family with sequence similarity 13, member B
FNDC3B fibronectin type III domain containing 3B
FOXO3 forkhead box O3
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
FZD7 frizzled class receptor 7
GABPB1 GA binding protein transcription factor, beta subunit 1
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GATA2 GATA binding protein 2
GGNBP2 gametogenetin binding protein 2
GOSR1 golgi SNAP receptor complex member 1
GRWD1 glutamate-rich WD repeat containing 1
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa
HEXIM1 hexamethylene bis-acetamide inducible 1
HN1 hematological and neurological expressed 1
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1
HOMER1 homer scaffolding protein 1
HOXA5 homeobox A5
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
IER5 immediate early response 5
IGF1R insulin-like growth factor 1 receptor
IGFBP6 insulin-like growth factor binding protein 6
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
INTS5 integrator complex subunit 5
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2
IST1 increased sodium tolerance 1 homolog (yeast)
JADE2 jade family PHD finger 2
JARID2 jumonji, AT rich interactive domain 2
JMJD6 jumonji domain containing 6
KDM5B lysine (K)-specific demethylase 5B
KEAP1 kelch-like ECH-associated protein 1
KIAA0485 uncharacterized LOC57235
KIAA0907 KIAA0907
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIN Kin17 DNA and RNA binding protein
KIZ kizuna centrosomal protein
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT7 keratin 7, type II
LIPT1 lipoyltransferase 1
LMO2 LIM domain only 2 (rhombotin-like 1)
LRIF1 ligand dependent nuclear receptor interacting factor 1
MAPK6 mitogen-activated protein kinase 6
MAT2A methionine adenosyltransferase II, alpha
MED13 mediator complex subunit 13
MEPCE methylphosphate capping enzyme
METTL18 methyltransferase like 18
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MLH3 mutL homolog 3
MPHOSPH8 M-phase phosphoprotein 8
MRFAP1L1 Morf4 family associated protein 1-like 1
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYLIP myosin regulatory light chain interacting protein
N4BP2L2 NEDD4 binding protein 2-like 2
NCK1 NCK adaptor protein 1
NDC80 NDC80 kinetochore complex component
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NOP16 NOP16 nucleolar protein
NOTCH2NL notch 2 N-terminal like
NRBF2 nuclear receptor binding factor 2
NRIP1 nuclear receptor interacting protein 1
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
NXT1 nuclear transport factor 2-like export factor 1
OXTR oxytocin receptor
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PDGFA platelet-derived growth factor alpha polypeptide
PDS5B PDS5 cohesin associated factor B
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLA2G15 phospholipase A2, group XV
PLK1 polo-like kinase 1
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D
PRUNE prune exopolyphosphatase
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6
PSMD12 proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
PSPC1 paraspeckle component 1
PTRH2 peptidyl-tRNA hydrolase 2
PURA purine-rich element binding protein A
RABIF RAB interacting factor
RAD9A RAD9 homolog A (S. pombe)
RAE1 ribonucleic acid export 1
RANBP2 RAN binding protein 2
RANBP6 RAN binding protein 6
RBM15 RNA binding motif protein 15
RBM34 RNA binding motif protein 34
RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase
RGS4 regulator of G-protein signaling 4
RNF113A ring finger protein 113A
RNMT RNA (guanine-7-) methyltransferase
RPL36AL ribosomal protein L36a-like
RPP38 ribonuclease P/MRP 38kDa subunit
RRP1B ribosomal RNA processing 1B
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100PBP S100P binding protein
SACS sacsin molecular chaperone
SCAF8 SR-related CTD-associated factor 8
SCYL3 SCY1-like 3 (S. cerevisiae)
SESN1 sestrin 1
SETD5 SET domain containing 5
SIX1 SIX homeobox 1
SIX2 SIX homeobox 2
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SMAD3 SMAD family member 3
SMURF2 SMAD specific E3 ubiquitin protein ligase 2
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa
SOX4 SRY (sex determining region Y)-box 4
SPDL1 spindle apparatus coiled-coil protein 1
SRSF7 serine/arginine-rich splicing factor 7
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SUV420H1 suppressor of variegation 4-20 homolog 1 (Drosophila)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TAF5 TAF5 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 100kDa
TBP TATA box binding protein
TBPL1 TBP-like 1
TBX2 T-box 2
TESC tescalcin
TEX10 testis expressed 10
TFAM transcription factor A, mitochondrial
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGIF1 TGFB-induced factor homeobox 1
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLE3 transducin-like enhancer of split 3
TLK2 tousled-like kinase 2
TNPO1 transportin 1
TOB1 transducer of ERBB2, 1
TRAPPC3 trafficking protein particle complex 3
TSC22D2 TSC22 domain family, member 2
TUBD1 tubulin, delta 1
TXLNA taxilin alpha
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP1 ubiquitin specific peptidase 1
USP22 ubiquitin specific peptidase 22
WAC WW domain containing adaptor with coiled-coil
WDR43 WD repeat domain 43
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
ZBED5 zinc finger, BED-type containing 5
ZBTB1 zinc finger and BTB domain containing 1
ZMYM2 zinc finger, MYM-type 2
ZNF267 zinc finger protein 267
ZNF430 zinc finger protein 430
ZNF443 zinc finger protein 443
ZNF473 zinc finger protein 473