BRD-A02333338_C3393M50_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

129 genes differentially expressed following the BRD-A02333338_C3393M50_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACOT7 acyl-CoA thioesterase 7
AGR2 anterior gradient 2
ALCAM activated leukocyte cell adhesion molecule
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
AQP1 aquaporin 1 (Colton blood group)
BLNK B-cell linker
CAV1 caveolin 1, caveolae protein, 22kDa
CD36 CD36 molecule (thrombospondin receptor)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CLC Charcot-Leyden crystal galectin
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSS cathepsin S
EFNB2 ephrin-B2
EID1 EP300 interacting inhibitor of differentiation 1
EMP1 epithelial membrane protein 1
EXPH5 exophilin 5
EZR ezrin
FXYD3 FXYD domain containing ion transport regulator 3
FYB FYN binding protein
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GPM6A glycoprotein M6A
HBB hemoglobin, beta
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IFITM1 interferon induced transmembrane protein 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP5 insulin-like growth factor binding protein 5
IQGAP1 IQ motif containing GTPase activating protein 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
LAMP3 lysosomal-associated membrane protein 3
LEF1 lymphoid enhancer-binding factor 1
LTF lactotransferrin
MDFIC MyoD family inhibitor domain containing
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MUC5B mucin 5B, oligomeric mucus/gel-forming
NEBL nebulette
NELL2 NEL-like 2 (chicken)
NID2 nidogen 2 (osteonidogen)
NOTCH3 notch 3
NTS neurotensin
OLFM1 olfactomedin 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PRKCB protein kinase C, beta
RAB31 RAB31, member RAS oncogene family
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
S100A8 S100 calcium binding protein A8
SOX11 SRY (sex determining region Y)-box 11
TCF4 transcription factor 4
TFF1 trefoil factor 1
TMEM47 transmembrane protein 47
TRD T cell receptor delta locus
TSPAN8 tetraspanin 8
ZNF264 zinc finger protein 264
ZSCAN18 zinc finger and SCAN domain containing 18

decreased expression

Symbol Name
AURKA aurora kinase A
AXIN1 axin 1
BAMBI BMP and activin membrane-bound inhibitor
BCL6 B-cell CLL/lymphoma 6
BRPF1 bromodomain and PHD finger containing, 1
BYSL bystin-like
CCNF cyclin F
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDK7 cyclin-dependent kinase 7
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPZ CCAAT/enhancer binding protein (C/EBP), zeta
CEP76 centrosomal protein 76kDa
CKS2 CDC28 protein kinase regulatory subunit 2
CSNK1D casein kinase 1, delta
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FASTKD5 FAST kinase domains 5
H2AFX H2A histone family, member X
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HOXA5 homeobox A5
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
JMJD6 jumonji domain containing 6
KDM3A lysine (K)-specific demethylase 3A
KEAP1 kelch-like ECH-associated protein 1
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KRT14 keratin 14, type I
LAPTM4B lysosomal protein transmembrane 4 beta
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MFSD10 major facilitator superfamily domain containing 10
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NET1 neuroepithelial cell transforming 1
NFIL3 nuclear factor, interleukin 3 regulated
NGDN neuroguidin, EIF4E binding protein
NOL11 nucleolar protein 11
NUP62 nucleoporin 62kDa
NUP85 nucleoporin 85kDa
NXN nucleoredoxin
NXT1 nuclear transport factor 2-like export factor 1
OSER1 oxidative stress responsive serine-rich 1
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PMM2 phosphomannomutase 2
PROM1 prominin 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
SAMD4A sterile alpha motif domain containing 4A
SETD5 SET domain containing 5
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TUBA4A tubulin, alpha 4a
TUBB2A tubulin, beta 2A class IIa
TXLNA taxilin alpha
WEE1 WEE1 G2 checkpoint kinase
ZFP36L2 ZFP36 ring finger protein-like 2