BRD-A02180903_BETAMETHASONE_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

199 genes differentially expressed following the BRD-A02180903_BETAMETHASONE_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRF5 adhesion G protein-coupled receptor F5
AIM1 absent in melanoma 1
ALOX15B arachidonate 15-lipoxygenase, type B
AOX1 aldehyde oxidase 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASS1 argininosuccinate synthase 1
BCHE butyrylcholinesterase
BCL6 B-cell CLL/lymphoma 6
C10ORF10 chromosome 10 open reading frame 10
C3 complement component 3
C3ORF14 chromosome 3 open reading frame 14
CALML4 calmodulin-like 4
CD163 CD163 molecule
CD302 CD302 molecule
CD47 CD47 molecule
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COBLL1 cordon-bleu WH2 repeat protein-like 1
CPM carboxypeptidase M
CRABP2 cellular retinoic acid binding protein 2
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
DUSP1 dual specificity phosphatase 1
EHD3 EH-domain containing 3
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
FAIM Fas apoptotic inhibitory molecule
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FKBP5 FK506 binding protein 5
FPR1 formyl peptide receptor 1
GADD45B growth arrest and DNA-damage-inducible, beta
GLUL glutamate-ammonia ligase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP5 insulin-like growth factor binding protein 5
IL1R1 interleukin 1 receptor, type I
IRAK3 interleukin-1 receptor-associated kinase 3
ITM2A integral membrane protein 2A
JADE2 jade family PHD finger 2
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KLF9 Kruppel-like factor 9
KRT19 keratin 19, type I
LOC100505650 uncharacterized LOC100505650
MAOA monoamine oxidase A
MAOB monoamine oxidase B
MFAP5 microfibrillar associated protein 5
MMP7 matrix metallopeptidase 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MTSS1 metastasis suppressor 1
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYH11 myosin, heavy chain 11, smooth muscle
NCAM1 neural cell adhesion molecule 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NMU neuromedin U
NNMT nicotinamide N-methyltransferase
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOTCH1 notch 1
NPTX2 neuronal pentraxin II
NRCAM neuronal cell adhesion molecule
ORM1 orosomucoid 1
PAM peptidylglycine alpha-amidating monooxygenase
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE4DIP phosphodiesterase 4D interacting protein
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM1 PDZ and LIM domain 1
PDZK1IP1 PDZK1 interacting protein 1
PER1 period circadian clock 1
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PPL periplakin
PRR15L proline rich 15-like
PRUNE2 prune homolog 2 (Drosophila)
RGCC regulator of cell cycle
RGS1 regulator of G-protein signaling 1
RGS2 regulator of G-protein signaling 2
S100A8 S100 calcium binding protein A8
SCG2 secretogranin II
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDC1 syndecan 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SIK1 salt-inducible kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC38A2 solute carrier family 38, member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SLPI secretory leukocyte peptidase inhibitor
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SNAI2 snail family zinc finger 2
SORBS2 sorbin and SH3 domain containing 2
SRGN serglycin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYBU syntabulin (syntaxin-interacting)
TKT transketolase
TOX thymocyte selection-associated high mobility group box
TSC22D3 TSC22 domain family, member 3
TSPAN12 tetraspanin 12
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
AK1 adenylate kinase 1
AKR1C1 aldo-keto reductase family 1, member C1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANO1 anoctamin 1, calcium activated chloride channel
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ARL4C ADP-ribosylation factor-like 4C
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BAMBI BMP and activin membrane-bound inhibitor
BCLAF1 BCL2-associated transcription factor 1
CBR3 carbonyl reductase 3
CCL2 chemokine (C-C motif) ligand 2
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CHPT1 choline phosphotransferase 1
CKM creatine kinase, muscle
COL5A2 collagen, type V, alpha 2
CST7 cystatin F (leukocystatin)
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DDB2 damage-specific DNA binding protein 2, 48kDa
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DUSP4 dual specificity phosphatase 4
ETV1 ets variant 1
FHL2 four and a half LIM domains 2
FOLR1 folate receptor 1 (adult)
FOSL1 FOS-like antigen 1
GCLM glutamate-cysteine ligase, modifier subunit
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX2 glutathione peroxidase 2
GSTM3 glutathione S-transferase mu 3 (brain)
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HBEGF heparin-binding EGF-like growth factor
ICAM1 intercellular adhesion molecule 1
IER3 immediate early response 3
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIF leukemia inhibitory factor
MACF1 microtubule-actin crosslinking factor 1
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast)
MAPK1 mitogen-activated protein kinase 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
NAV3 neuron navigator 3
NFE2L2 nuclear factor, erythroid 2-like 2
PENK proenkephalin
PHLDA1 pleckstrin homology-like domain, family A, member 1
PJA2 praja ring finger 2, E3 ubiquitin protein ligase
PLAU plasminogen activator, urokinase
PLK2 polo-like kinase 2
PLP1 proteolipid protein 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
QKI QKI, KH domain containing, RNA binding
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS4 regulator of G-protein signaling 4
S100B S100 calcium binding protein B
SECISBP2L SECIS binding protein 2-like
SF3B1 splicing factor 3b, subunit 1, 155kDa
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
SOX9 SRY (sex determining region Y)-box 9
SPRY2 sprouty homolog 2 (Drosophila)
SQSTM1 sequestosome 1
STMN1 stathmin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TXNRD1 thioredoxin reductase 1
TYMS thymidylate synthetase
UGDH UDP-glucose 6-dehydrogenase
VCAM1 vascular cell adhesion molecule 1
WARS tryptophanyl-tRNA synthetase
WIF1 WNT inhibitory factor 1
WSB2 WD repeat and SOCS box containing 2
YME1L1 YME1-like 1 ATPase