BRD-A02180903_BETAMETHASONE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A02180903_BETAMETHASONE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT1 acetyl-CoA acetyltransferase 1
ACSL1 acyl-CoA synthetase long-chain family member 1
ACTA2 actin, alpha 2, smooth muscle, aorta
ADO 2-aminoethanethiol (cysteamine) dioxygenase
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
BIRC3 baculoviral IAP repeat containing 3
C3 complement component 3
CCL20 chemokine (C-C motif) ligand 20
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CFB complement factor B
CFLAR CASP8 and FADD-like apoptosis regulator
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLEC11A C-type lectin domain family 11, member A
CYB5A cytochrome b5 type A (microsomal)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FKBP5 FK506 binding protein 5
GLUL glutamate-ammonia ligase
KDM5D lysine (K)-specific demethylase 5D
KLF6 Kruppel-like factor 6
MAOA monoamine oxidase A
MME membrane metallo-endopeptidase
MTUS1 microtubule associated tumor suppressor 1
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAMPT nicotinamide phosphoribosyltransferase
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PER1 period circadian clock 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SIDT2 SID1 transmembrane family, member 2
SLC31A2 solute carrier family 31 (copper transporter), member 2
SLPI secretory leukocyte peptidase inhibitor
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SOD2 superoxide dismutase 2, mitochondrial
SPINK1 serine peptidase inhibitor, Kazal type 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TSC22D3 TSC22 domain family, member 3
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
AXL AXL receptor tyrosine kinase
BMP2 bone morphogenetic protein 2
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CLEC2B C-type lectin domain family 2, member B
COL4A2 collagen, type IV, alpha 2
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
DKK3 dickkopf WNT signaling pathway inhibitor 3
DST dystonin
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ETV5 ets variant 5
EXT1 exostosin glycosyltransferase 1
FANCL Fanconi anemia, complementation group L
FBN2 fibrillin 2
FHL2 four and a half LIM domains 2
FOXF2 forkhead box F2
FSTL1 follistatin-like 1
GJA1 gap junction protein, alpha 1, 43kDa
GLIPR1 GLI pathogenesis-related 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
IER3 immediate early response 3
ITGA6 integrin, alpha 6
KIF2C kinesin family member 2C
LGALS1 lectin, galactoside-binding, soluble, 1
LPAR6 lysophosphatidic acid receptor 6
LXN latexin
MATN2 matrilin 2
MDFIC MyoD family inhibitor domain containing
MDK midkine (neurite growth-promoting factor 2)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle
NDNF neuron-derived neurotrophic factor
NTS neurotensin
P3H2 prolyl 3-hydroxylase 2
PLK2 polo-like kinase 2
PRDX2 peroxiredoxin 2
PTN pleiotrophin
RND3 Rho family GTPase 3
RPS11 ribosomal protein S11
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SHB Src homology 2 domain containing adaptor protein B
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SPDEF SAM pointed domain containing ETS transcription factor
SQSTM1 sequestosome 1
SV2A synaptic vesicle glycoprotein 2A
TBX3 T-box 3
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMELESS timeless circadian clock
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPM1 tropomyosin 1 (alpha)
TUBA4A tubulin, alpha 4a
UGCG UDP-glucose ceramide glucosyltransferase
WIF1 WNT inhibitory factor 1
WNT5A wingless-type MMTV integration site family, member 5A
XIST X inactive specific transcript (non-protein coding)
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon