BRD-A02180903_BETAMETHASONE_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

82 genes differentially expressed following the BRD-A02180903_BETAMETHASONE_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALCAM activated leukocyte cell adhesion molecule
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BPIFA1 BPI fold containing family A, member 1
C21ORF91 chromosome 21 open reading frame 91
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCND2 cyclin D2
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL14 chemokine (C-X-C motif) ligand 14
DDIT4 DNA-damage-inducible transcript 4
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
EIF5A eukaryotic translation initiation factor 5A
FA2H fatty acid 2-hydroxylase
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FKBP5 FK506 binding protein 5
GM2A GM2 ganglioside activator
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HNRNPL heterogeneous nuclear ribonucleoprotein L
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
JADE2 jade family PHD finger 2
LPL lipoprotein lipase
MAOA monoamine oxidase A
MAP7 microtubule-associated protein 7
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1X metallothionein 1X
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NUTF2 nuclear transport factor 2
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SGK1 serum/glucocorticoid regulated kinase 1
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SRSF6 serine/arginine-rich splicing factor 6
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
STK39 serine threonine kinase 39
TACSTD2 tumor-associated calcium signal transducer 2
TF transferrin
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ADCY2 adenylate cyclase 2 (brain)
ADGRG2 adhesion G protein-coupled receptor G2
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
ATF3 activating transcription factor 3
BTG3 BTG family, member 3
CKAP4 cytoskeleton-associated protein 4
CLGN calmegin
COL1A2 collagen, type I, alpha 2
COL6A2 collagen, type VI, alpha 2
CRISP3 cysteine-rich secretory protein 3
CXCL10 chemokine (C-X-C motif) ligand 10
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
EIF1 eukaryotic translation initiation factor 1
ESR1 estrogen receptor 1
GEM GTP binding protein overexpressed in skeletal muscle
HOXB2 homeobox B2
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPB8 heat shock 22kDa protein 8
IER3 immediate early response 3
MEST mesoderm specific transcript
NRN1 neuritin 1
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SHB Src homology 2 domain containing adaptor protein B
SOD2 superoxide dismutase 2, mitochondrial
SULF1 sulfatase 1
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFRC transferrin receptor
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
VCAM1 vascular cell adhesion molecule 1
VEGFA vascular endothelial growth factor A
ZNF331 zinc finger protein 331