BRD-A01645196_garcinol_HEPG2_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

188 genes differentially expressed following the BRD-A01645196_garcinol_HEPG2_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAA1 acetyl-CoA acyltransferase 1
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial)
ALDOB aldolase B, fructose-bisphosphate
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATM ATM serine/threonine kinase
BAG2 BCL2-associated athanogene 2
BHLHE41 basic helix-loop-helix family, member e41
CAPN2 calpain 2, (m/II) large subunit
CCL5 chemokine (C-C motif) ligand 5
CCND1 cyclin D1
CD8A CD8a molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDCP1 CUB domain containing protein 1
CES1 carboxylesterase 1
COL11A1 collagen, type XI, alpha 1
COLGALT2 collagen beta(1-O)galactosyltransferase 2
CST1 cystatin SN
CTGF connective tissue growth factor
CTSB cathepsin B
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL6 chemokine (C-X-C motif) ligand 6
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
DUSP6 dual specificity phosphatase 6
EGFL6 EGF-like-domain, multiple 6
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
EMP1 epithelial membrane protein 1
EPCAM epithelial cell adhesion molecule
FHL2 four and a half LIM domains 2
FMO2 flavin containing monooxygenase 2 (non-functional)
G0S2 G0/G1 switch 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GNLY granulysin
GPX2 glutathione peroxidase 2
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HES1 hes family bHLH transcription factor 1
HGD homogentisate 1,2-dioxygenase
HMGA1 high mobility group AT-hook 1
IER3 immediate early response 3
IGHM immunoglobulin heavy constant mu
KLRK1 killer cell lectin-like receptor subfamily K, member 1
KRT19 keratin 19, type I
KRT7 keratin 7, type II
KYNU kynureninase
LAMC2 laminin, gamma 2
LRP10 low density lipoprotein receptor-related protein 10
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MCOLN1 mucolipin 1
MME membrane metallo-endopeptidase
MMP12 matrix metallopeptidase 12
MMP7 matrix metallopeptidase 7
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MX1 MX dynamin-like GTPase 1
MYO6 myosin VI
NOTCH1 notch 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa
PDGFA platelet-derived growth factor alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PSAT1 phosphoserine aminotransferase 1
RAB29 RAB29, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
RND3 Rho family GTPase 3
RRAGD Ras-related GTP binding D
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC22A18 solute carrier family 22, member 18
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SPATS2L spermatogenesis associated, serine-rich 2-like
SQSTM1 sequestosome 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
STEAP1 six transmembrane epithelial antigen of the prostate 1
TGFBR3 transforming growth factor, beta receptor III
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TOMM34 translocase of outer mitochondrial membrane 34
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
VNN1 vanin 1
XPOT exportin, tRNA

decreased expression

Symbol Name
ACTR2 ARP2 actin-related protein 2 homolog (yeast)
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
BIRC5 baculoviral IAP repeat containing 5
C6ORF62 chromosome 6 open reading frame 62
CA2 carbonic anhydrase II
CARHSP1 calcium regulated heat stable protein 1, 24kDa
CCNA2 cyclin A2
CCNB2 cyclin B2
CD36 CD36 molecule (thrombospondin receptor)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CHEK2 checkpoint kinase 2
CKS1B CDC28 protein kinase regulatory subunit 1B
CLU clusterin
CORO1A coronin, actin binding protein, 1A
CREG1 cellular repressor of E1A-stimulated genes 1
CRLF1 cytokine receptor-like factor 1
CTSV cathepsin V
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DMD dystrophin
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
EMP2 epithelial membrane protein 2
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
FABP7 fatty acid binding protein 7, brain
FEN1 flap structure-specific endonuclease 1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GJA1 gap junction protein, alpha 1, 43kDa
H2AFX H2A histone family, member X
HILPDA hypoxia inducible lipid droplet-associated
HIST1H1C histone cluster 1, H1c
HIST1H4C histone cluster 1, H4c
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRS2 insulin receptor substrate 2
KANK2 KN motif and ankyrin repeat domains 2
KIAA0101 KIAA0101
KIAA0355 KIAA0355
KLK11 kallikrein-related peptidase 11
KRT14 keratin 14, type I
LMNB1 lamin B1
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MELK maternal embryonic leucine zipper kinase
MLEC malectin
MREG melanoregulin
MSMO1 methylsterol monooxygenase 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NREP neuronal regeneration related protein
NSDHL NAD(P) dependent steroid dehydrogenase-like
NUSAP1 nucleolar and spindle associated protein 1
PDAP1 PDGFA associated protein 1
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIC peptidylprolyl isomerase C (cyclophilin C)
PRC1 protein regulator of cytokinesis 1
PTTG1 pituitary tumor-transforming 1
PXMP2 peroxisomal membrane protein 2, 22kDa
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1
RFC3 replication factor C (activator 1) 3, 38kDa
RPIA ribose 5-phosphate isomerase A
RRM2 ribonucleotide reductase M2
S100A7 S100 calcium binding protein A7
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
STMN1 stathmin 1
TK1 thymidine kinase 1, soluble
TMEM243 transmembrane protein 243, mitochondrial
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM2 tripartite motif containing 2
TSPAN13 tetraspanin 13
TTN titin
TUBB2A tubulin, beta 2A class IIa
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
YKT6 YKT6 v-SNARE homolog (S. cerevisiae)