BRD-A01645196_garcinol_A375_24_h_10_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

113 genes differentially expressed following the BRD-A01645196_garcinol_A375_24_h_10_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTA1 actin, alpha 1, skeletal muscle
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX2 armadillo repeat containing, X-linked 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATM ATM serine/threonine kinase
CBS cystathionine-beta-synthase
CCL19 chemokine (C-C motif) ligand 19
CCNA1 cyclin A1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COL14A1 collagen, type XIV, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CXCL12 chemokine (C-X-C motif) ligand 12
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DLK1 delta-like 1 homolog (Drosophila)
EFNB2 ephrin-B2
EGR1 early growth response 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FAM129A family with sequence similarity 129, member A
FOLR1 folate receptor 1 (adult)
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
HMOX1 heme oxygenase 1
KLHL41 kelch-like family member 41
LPAR2 lysophosphatidic acid receptor 2
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MME membrane metallo-endopeptidase
MT1M metallothionein 1M
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NARS asparaginyl-tRNA synthetase
ODC1 ornithine decarboxylase 1
PALLD palladin, cytoskeletal associated protein
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PER2 period circadian clock 2
PHGDH phosphoglycerate dehydrogenase
PHYH phytanoyl-CoA 2-hydroxylase
PPAP2A phosphatidic acid phosphatase type 2A
PTN pleiotrophin
PYCR1 pyrroline-5-carboxylate reductase 1
RRAGD Ras-related GTP binding D
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SQSTM1 sequestosome 1
TESC tescalcin
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
THBS4 thrombospondin 4
TNNC1 troponin C type 1 (slow)
TTN titin
TUBB2A tubulin, beta 2A class IIa
TXNRD1 thioredoxin reductase 1
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
YBX3 Y box binding protein 3
ZBTB18 zinc finger and BTB domain containing 18

decreased expression

Symbol Name
AK2 adenylate kinase 2
AK4 adenylate kinase 4
ALDOC aldolase C, fructose-bisphosphate
BICD2 bicaudal D homolog 2 (Drosophila)
CA12 carbonic anhydrase XII
CCND2 cyclin D2
CCNE2 cyclin E2
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL4A1 collagen, type IV, alpha 1
COL4A2 collagen, type IV, alpha 2
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DMTF1 cyclin D binding myb-like transcription factor 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENO1 enolase 1, (alpha)
FCGBP Fc fragment of IgG binding protein
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
HBB hemoglobin, beta
HCAR3 hydroxycarboxylic acid receptor 3
HIST1H2BG histone cluster 1, H2bg
HOPX HOP homeobox
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2
KANK1 KN motif and ankyrin repeat domains 1
LAMB1 laminin, beta 1
LEF1 lymphoid enhancer-binding factor 1
LGALS1 lectin, galactoside-binding, soluble, 1
NRIP1 nuclear receptor interacting protein 1
PKM pyruvate kinase, muscle
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PRKCA protein kinase C, alpha
PTMA prothymosin, alpha
S100A12 S100 calcium binding protein A12
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
STAG2 stromal antigen 2
TCF4 transcription factor 4
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF1 transmembrane 4 L six family member 1
TMPO thymopoietin
TUBB tubulin, beta class I
WNT5A wingless-type MMTV integration site family, member 5A