BRD-A01593789_CHLORMADINONE ACETATE_NPC_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

163 genes differentially expressed following the BRD-A01593789_CHLORMADINONE ACETATE_NPC_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AMOTL2 angiomotin like 2
ANXA1 annexin A1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AZU1 azurocidin 1
BRD4 bromodomain containing 4
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CD177 CD177 molecule
CD9 CD9 molecule
CDK6 cyclin-dependent kinase 6
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLCA4 chloride channel accessory 4
CNN3 calponin 3, acidic
CORO1C coronin, actin binding protein, 1C
CST7 cystatin F (leukocystatin)
CTGF connective tissue growth factor
CTSG cathepsin G
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DHRS9 dehydrogenase/reductase (SDR family) member 9
DUSP8 dual specificity phosphatase 8
EDN1 endothelin 1
EGR1 early growth response 1
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELANE elastase, neutrophil expressed
EPCAM epithelial cell adhesion molecule
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FKBP11 FK506 binding protein 11, 19 kDa
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GDF15 growth differentiation factor 15
GLIPR1 GLI pathogenesis-related 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRIA2 glutamate receptor, ionotropic, AMPA 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HBEGF heparin-binding EGF-like growth factor
HDAC9 histone deacetylase 9
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMOX1 heme oxygenase 1
HSPB8 heat shock 22kDa protein 8
IGF1R insulin-like growth factor 1 receptor
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IPO7 importin 7
ITGAV integrin, alpha V
KLF2 Kruppel-like factor 2
KLF9 Kruppel-like factor 9
LCN2 lipocalin 2
LITAF lipopolysaccharide-induced TNF factor
LPL lipoprotein lipase
MAP1B microtubule-associated protein 1B
MBNL2 muscleblind-like splicing regulator 2
MCAM melanoma cell adhesion molecule
MCTP1 multiple C2 domains, transmembrane 1
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP7 matrix metallopeptidase 7
MS4A12 membrane-spanning 4-domains, subfamily A, member 12
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MT1E metallothionein 1E
MT1M metallothionein 1M
MT1X metallothionein 1X
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCAM1 neural cell adhesion molecule 1
NEFL neurofilament, light polypeptide
NRIP1 nuclear receptor interacting protein 1
PHGDH phosphoglycerate dehydrogenase
PLK2 polo-like kinase 2
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit
PRSS21 protease, serine, 21 (testisin)
PRSS23 protease, serine, 23
PRTN3 proteinase 3
PSAT1 phosphoserine aminotransferase 1
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SQSTM1 sequestosome 1
TACSTD2 tumor-associated calcium signal transducer 2
TFPI2 tissue factor pathway inhibitor 2
TPM1 tropomyosin 1 (alpha)
TXNRD1 thioredoxin reductase 1
UFM1 ubiquitin-fold modifier 1
VLDLR very low density lipoprotein receptor
ZFP36 ZFP36 ring finger protein
ZYX zyxin

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ACOT7 acyl-CoA thioesterase 7
ADD3 adducin 3 (gamma)
ADGRG2 adhesion G protein-coupled receptor G2
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AKAP7 A kinase (PRKA) anchor protein 7
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
B3GNT1
BDH2 3-hydroxybutyrate dehydrogenase, type 2
C6ORF62 chromosome 6 open reading frame 62
CCNF cyclin F
CLIC3 chloride intracellular channel 3
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CTSL cathepsin L
DAPK1 death-associated protein kinase 1
DIO2 deiodinase, iodothyronine, type II
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNA4 ephrin-A4
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FBLN1 fibulin 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GMNN geminin, DNA replication inhibitor
GSTA1 glutathione S-transferase alpha 1
HMGB3 high mobility group box 3
HSPA8 heat shock 70kDa protein 8
LANCL1 LanC lantibiotic synthetase component C-like 1 (bacterial)
LY6E lymphocyte antigen 6 complex, locus E
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
METRN meteorin, glial cell differentiation regulator
MSH6 mutS homolog 6
NFIL3 nuclear factor, interleukin 3 regulated
NIPSNAP1 nipsnap homolog 1 (C. elegans)
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa)
PDIA4 protein disulfide isomerase family A, member 4
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PLSCR3 phospholipid scramblase 3
RPA1 replication protein A1, 70kDa
RPS11 ribosomal protein S11
SCARB2 scavenger receptor class B, member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8
TCAF1 TRPM8 channel-associated factor 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM14 tripartite motif containing 14
TRIM29 tripartite motif containing 29
TUBB tubulin, beta class I
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WDR61 WD repeat domain 61
WNT5A wingless-type MMTV integration site family, member 5A